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Volumn 20, Issue 10, 2009, Pages 1183-1186

Oxidation of 3,4-dihydropyrimidin-2(1H)-ones with nitrosonium (NO+)

Author keywords

Dihydropyrimidinone; Nitrosonium; Oxidation

Indexed keywords


EID: 68749093795     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2009.04.039     Document Type: Article
Times cited : (11)

References (49)
  • 1
    • 0004135137 scopus 로고
    • John Wiley & Sons, New York
    • Brown D.J. The Pyrimidines 31 (1962), John Wiley & Sons, New York
    • (1962) The Pyrimidines , vol.31
    • Brown, D.J.1
  • 34
    • 68749107262 scopus 로고    scopus 로고
    • A typical experimental procedure: a 25 mL round bottom flask with a magnetic bar was charged with 0.5 mmol of 1c, following the method described in Ref, 6b, and 10 mL of CH3CN. To this suspension was added 0.6 mmol (1.2 equiv, of NO+BF4, The reaction mixture became clear. The solution was stirred at room temperature for 2.5 h until TLC showed the completion of reaction. The solution was then concentrated under vacuum and purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 1:2, v/v) to afford pure 2c. The single crystal was grown in chloroform-hexane at room temperature. All products were identified by 1H and 13C NMR, MS, IR, and HR-ESI-MS. Selected data for compound 2c: white solid, mp 187-188 °C; IR (KBr, max 3408, 2984, 2907, 1717, 1658, 1598, 1437, 1279, 1097, 840 and 800 cm-1. 1H NMR (400 MHz, CDCl3, δ (ppm, 10.35 (br, s, 1H, 7.56 d, 2H
    • 2 = 0.1150. The crystallographic data have been deposited at the Cambridge Crystallographic Data Center as supplementary publication No. CCDC-702066.
  • 39
    • 68749118546 scopus 로고    scopus 로고
    • +), 293, 265, 221, 183, 155, 137, 111 and 83.
    • +), 293, 265, 221, 183, 155, 137, 111 and 83.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.