Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens

Molecular Vision

Volumn 15, Issue , 2009, Pages 1492-1508

  Biswas, Sondip K ^a   Jiang, Jean X ^c   Lo, Woo Kuen ^a,b  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CONNEXIN 50; FILIPIN; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL AGING; CELL JUNCTION; CELL MATURATION; CELL MEMBRANE; CYTOCHEMISTRY; DENSITY; FREEZE FRACTURE; GAP JUNCTION; IMMUNOGOLD LABELING; LENS; LENS FIBER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL DIFFERENTIATION; CHICKENS; CHOLESTEROL; CONNEXINS; EYE PROTEINS; FILIPIN; FREEZE FRACTURING; GAP JUNCTIONS; LENS, CRYSTALLINE; MODELS, BIOLOGICAL;

EID: 68749086087     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Cenedella RJ. Sterol synthesis by the ocular lens of the rat during postnatal development. J Lipid Res 1982; 23:619-26.
2. Zelenka PS. Lens lipids. Curr Eye Res 1984; 3:1337-59.
3. Li LK, So L, Spector A. Membrane cholesterol and phospholipid in consecutive concentric sections of human lenses. J Lipid Res 1985; 26:600-9.
4. Li LK, So L, Spector A. Age-dependent changes in the distribution and concentration of human lens cholesterol and phospholipids. Biochim Biophys Acta 1987; 917:112-20.
5. Li LK, So L. Age dependent lipid and protein changes in individual bovine lenses. Curr Eye Res 1987; 6:599-605.
6. Borchman D, Delamere NA, McCauley LA, Paterson CA. Studies on the distribution of cholesterol, phospholipid, and protein in the human and bovine lens. Lens Eye Toxic Res 1989; 6:703-24.
7. Biswas SK, Lo WK. Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens. Mol Vis 2007; 13:345-59.
8. Berthoud VM, Cook AJ, Beyer EC. Characterization of the gap junction protein connexin56 in the chicken lens by immunofluorescence and immunoblotting. Invest Ophthalmol Vis Sci 1994; 35:4109-17.
9. Gong X, Baldo GJ, Kumar NM, Gilula NB, Mathias RT. Gap junctional coupling in lenses lacking alpha3 connexin. Proc Natl Acad Sci USA 1998; 95:15303-8.
10. Berthoud VM, Tadros PN, Beyer EC. Connexin and gap junction degradation. Methods 2000; 20:180-7.
11. Windoffer R, Beile B, Leibold A, Thomas S, Wilhelm U, Leube RE. Visualization of gap junction mobility in living cells. Cell Tissue Res 2000; 299:347-62.
12. Jordan K, Chodock R, Hand AR, Laird DW. The origin of annular junctions: a mechanism of gap junction internalization. J Cell Sci 2001; 114:763-73.
13. Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science 2002; 296:503-7.
14. Benedetti EL, Dunia I, Bentzel CJ, Vermorken AJ, Kibbelaar M, Bloemendal H. A portrait of plasma membrane specializations in eye lens epithelium and fibers. Biochim Biophys Acta 1976; 457:353-84.
15. Sheridan JD, Hammer-Wilson M, Preus D, Johnson RG. Quantitative analysis of low-resistance junctions between cultured cells and correlation with gap-junctional areas. J Cell Biol 1978; 76:532-44.
16. Kuszak JR, Alcala J, Maisel H. Evidence for sequential replacement of gap junctions in chick lens development. Exp Eye Res 1982; 34:455-66.
17. Lo WK, Harding CV. Structure and distribution of gap junctions in lens epithelium and fiber cells. Cell Tissue Res 1986; 244:253-63.
18. Zampighi GA, Eskandari S, Kreman M. Epithelial organization of the mammalian lens. Exp Eye Res 2000; 71:415-35.
19. Evans WH, Ahmad S, Diez J, George CH, Kendall JM, Martin PE. Trafficking pathways leading to the formation of gap junctions. Novartis Found Symp 1999; 219:44-54.
20. George CH, Kendall JM, Evans WH. Intracellular trafficking pathways in the assembly of connexins into gap junctions. J Biol Chem 1999; 274:8678-85.
21. Martin PE, Evans WH. Incorporation of connexins into plasma membranes and gap junctions. Cardiovasc Res 2004; 62:378-87.
22. Evans WH, Martin PE. Gap junctions: structure and function. Mol Membr Biol 2002; 19:121-36. Review
23. Laird DW. Life cycle of connexins in health and disease. Biochem J 2006; 394:527-43.
24. Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol 1991; 115:1077-89.
25. White TW, Bruzzone R, Goodenough DA, Paul DL. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell 1992; 3:711-20.
26. Kistler J, Kirkland B, Bullivant S. Identification of a 70,000-D protein in lens membrane junctional domains. J Cell Biol 1985; 101:28-35.
27. Yang DI, Louis CF. Molecular cloning of sheep connexin49 and its identity with MP70. Curr Eye Res 1996; 15:307-14.
28. Yang DI, Louis CF. Molecular cloning of ovine connexin44 and temporal expression of gap junction proteins in a lens cell culture. Invest Ophthalmol Vis Sci 2000; 41:2658-64.
29. Jiang JX, White TW, Goodenough DA, Paul DL. Molecular cloning and functional characterization of chick lens fiber connexin 45.6. Mol Biol Cell 1994; 5:363-73.
30. Rup DM, Veenstra RD, Wang HZ, Brink PR, Beyer EC. Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression. J Biol Chem 1993; 268:706-12.
31. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem 1996; 65:475-502.
32. Xu X, Berthoud VM, Beyer EC, Ebihara L. Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels. J Membr Biol 2002; 186:101-12.
33. Thomas MA, Huang S, Cokoja A, Riccio O, Staub O, Suter S, Chanso M. Interaction of connexins with protein partners in the control of channel turnover and gating. Biol Cell 2002; 94:445-56.
34. Zucker SN, Nicholson BJ. Mutagenic approaches to modifying gap junction phenotype. Curr Drug Targets 2002; 3:441-53.
35. Lin JS, Eckert R, Kistler J, Donaldson P. Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage. Eur J Cell Biol 1998; 76:246-50.
36. Yin X, Gu S, Jiang JX. Regulation of lens connexin 45.6 by apoptotic protease, caspase-3. Cell Commun Adhes 2001; 8:373-6.
37. DeRosa AM, Mui R, Srinivas M, White TW. Functional characterization of a naturally occurring Cx50 truncation. Invest Ophthalmol Vis Sci 2006; 47:4474-81.
38. Meyer R, Malewicz B, Baumann WJ, Johnson RG. Increased gap junction assembly between cultured cells upon cholesterol supplementation. J Cell Sci 1990; 96:231-8.
39. Malewicz B, Kumar VV, Johnson RG, Baumann WJ. Lipids in gap junction assembly and function. Lipids 1990; 25:419-27.
40. Meyer RA, Lampe PD, Malewicz B, Baumann WJ, Johnson RG. Enhanced gap junction formation with LDL and apolipoprotein B. Exp Cell Res 1991; 196:72-81.
41. Cenedella RJ. Regional distribution of sterol and fatty acid synthesis in the ocular lens. Exp Eye Res 1984; 38:95-9.
42. Andrews LD, Cohen AI. Freeze-fracture evidence for the presence of cholesterol in particle-free patches of basal disks and the plasma membrane of retinal rod outer segments of mice and frogs. J Cell Biol 1979; 81:215-28.
43. Andrews LD, Cohen AI. Freeze-fracture studies of photoreceptor membranes: new observations bearing upon the distribution of cholesterol. J Cell Biol 1983; 97:749-55.
44. Raviola E, Goodenough DA, Raviola G. Structure of rapidly frozen gap junctions. J Cell Biol 1980; 87:273-9.
45. Goodenough DA. Lens gap junctions: a structural hypothesis for nonregulated low-resistance intercellular pathways. Invest Ophthalmol Vis Sci 1979; 18:1104-22.
46. Yin X, Gu S, Jiang JX. The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation. J Biol Chem 2001; 276:34567-72.
47. Yin X, Liu J, Jiang JX. Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylation. Cell Commun Adhes 2008; 15:1-11.
48. Kuszak J, Maisel H, Harding CV. Gap junctions of chick lens fiber cells. Exp Eye Res 1978; 27:495-8.
49. Kuszak J, Alcala J, Maisel H. The surface morphology of embryonic and adult chick lens-fiber cells. Am J Anat 1980; 159:395-410.
50. Willekens B, Vrensen G. The three-dimensional organization of lens fibers in the rabbit. A scanning electron microscopic reinvestigation. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1981; 216:275-89.
51. Willekens B, Vrensen G. The three-dimensional organization of lens fibers in the rhesus monkey. Graefes Arch Clin Exp Ophthalmol 1982; 219:112-20.
52. Lo WK, Harding CV. Square arrays and their role in ridge formation in human lens fibers. J Ultrastruct Res 1984; 86:228-45.
53. Willekens B, Vrensen G. Lens fiber organization in four avian species: a scanning electron microscopic study. Tissue Cell 1985; 17:359-77.
54. Lo WK, Harding CV. Structure and distribution of gap junctions in lens epithelium and fiber cells. Cell Tissue Res 1986; 244:253-63.
55. Taylor VL, al-Ghoul KJ, Lane CW, Davis VA, Kuszak JR, Costello MJ. Morphology of the normal human lens. Invest Ophthalmol Vis Sci 1996; 37:1396-410.
56. al-Ghoul KJ, Nordgren RK, Kuszak AJ, Freel CD, Costello MJ, Kuszak JR. Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis. Exp Eye Res 2001; 72:199-214.
57. Yin X, Jedrzejewski PT, Jiang JX. Casein kinase II phosphorylates lens connexin 45.6 and is involved in its degradation. J Biol Chem 2000; 275:6850-6.
58. Mathias RT, Riquelme G, Rae JL. Cell to cell communication and pH in the frog lens. J Gen Physiol 1991; 98:1085-103.
59. Baldo GJ, Gong X, Martinez-Wittinghan FJ, Kumar NM, Gilula NB, Mathias RT. Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol 2001; 118:447-56.
60. Eckert R. pH gating of lens fibre connexins. Pflugers Arch 2002; 443:843-51.
61. Martinez-Wittinghan FJ, Sellitto C, White TW, Mathias RT, Paul D, Goodenough DA. Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression. Invest Ophthalmol Vis Sci 2004; 45:3629-37.
62. Martinez-Wittinghan FJ, Srinivas M, Sellitto C, White TW, Mathias RT. Mefloquine effects on the lens suggest cooperative gating of gap junction channels. J Membr Biol 2006; 211:163-71.