Antitumor activity and pharmacokinetics of podophyllotoxin incorporated into solid lipid nanoparticles

Science in China, Series B: Chemistry

Volumn 52, Issue 8, 2009, Pages 1253-1257

  Xue, Meng ^a   Zhu, Rongrong ^a   Qin, Lili ^a   Li, Fajie ^a   Liu, Zhixue ^a   Sun, Xiaoyu ^a   Wang, Shilong ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

Podophyllotoxin; Solid lipid nanoparticles; Tumor

Indexed keywords

ANIMAL MODEL; ANTI-TUMOR ACTIVITIES; ANTI-TUMORS; BLOOD CONCENTRATIONS; BLOOD DRUG LEVEL; BLOOD SAMPLES; BODY WEIGHT; CIRCULATION TIME; CLINICAL OBSERVATION; DRUG ADMINISTRATION; GROSS TUMOR VOLUME; INTRAPERITONEAL INJECTIONS; KUNMING MOUSE; NEGATIVE CONTROL; PHARMACOKINETIC PARAMETERS; PODOPHYLLOTOXIN; REDUCED TOXICITY; SOLID LIPID NANOPARTICLES; TIME CURVES; TUMOR INHIBITION; TUMOR VOLUMES; WEIGHT GAIN;

BIOCHEMISTRY; BLOOD; DRUG PRODUCTS; ETHANOL; NANOPARTICLES; PHARMACOKINETICS; TOXICITY;

TUMORS;

EID: 68649128854     PISSN: 10069291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11426-009-0035-x     Document Type: Article

References (20)

1. Kaplan I W. Codylomata acuminata. New Orleans Med Surg J, 1942, 388
2. K. L. Wallin F. Wiklund T. Angstrom F. Bergman U. Stendahl G. Wadell G. Hallmans J. Dillner 1999 Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer N Engl J Med 341 22 1633 1638
3. P. C. Sand K. Weisaman 1995 Quercetin and kaempherol. An argument against the use of podophyllin Genitourin Med 71 1 92 93
4. P. F. Yu H. Chen J. Wang C. X. He B. Cao M. Li N. Yang Z. Y. Lei M. S. Cheng 2008 Design, synthesis cytotoxicity of novel podophyllotoxin derivatives Chem Pharm Bull 56 6 831 834
5. P. B. Reddy D. V. Paul S. K. Agrawal A. K. Saxena H. M. Kumar G. N. Qazi 2008 Design, synthesis, and biological testing of 4beta-[(4-substituted)-1,2,3- triazol-1-yl]podophyllotoxin analogues as antitumor agents Arch Pharm (Weinheim) 341 2 126 131
6. S. L. Wang X. Y. Sun C. J. Zhang M. Wang W. Z. Li S. H. Liu Y. M. Ni S. D. Yao 2002 Antitumor mechanism of VP-16: A pulse radiolysis study Sci China Ser B-Chem 45 4 394 397
7. X. Y. Sun C. J. Zhang M. Wang S. L. Wang Y. M. Ni S. D. Yao 2002 Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin Sci China Ser B-Chem 45 2 191 199
8. S. L. Wang 1996 Oxidizing mechanism of podophyllotoxin and its derivatives by sodium persulfate Sci China Ser B-Chem 39 4 425 425
9. 2 Sci China Ser B-Chem 50 2 272 275
10. 2 nanoparticles on DNA synthesis in vitro Sci China Ser B-Chem 51 4 367 372
11. Y. H. Xue R. Zhang X. Y. Sun S. L. Wang 2008 The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins J Mater Sci: Mater Med 19 3 1197 1202
12. H. Zhu J. Z. Xu S. Q. Li X. Y. Sun S. D. Yao S. L. Wang 2008 Effects of high-energy-pulse-electron beam radiation on biomacromolecules Sci China Ser B-Chem 51 1 86 91
13. L. L. Qin S. L. Wang R. Zhang R. R. Zhu X. Y. Sun S. D. Yao 2008 Two different approaches to synthesizing Mg-Al-layered double hydroxides as folic acid carriers J Phys Chem Solids 69 11 2779 2784
14. P. Zhao M. Wang S. P. Zhang S. C. Shao X. Y. Sun S. D. Yao S. L. Wang 2008 Photochemical properties of a new kind of anti-cancer drug: N-glycoside compound Sci China Ser B-Chem 51 9 872 877
15. S. P. Vyas S. Rai R. Paliwal P. N. Gupta K. Khatri A. Goyal B. Vaidya 2008 Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science: One step up in nanotechnology Curr Nanosci 4 1 30 44
16. Wang S L, Sun X Y, Zhang R, Nie Q, Yao S D. Chin Patent, CN200510111606.3
17. X. Y. Zhang J. M. Ni H. Qiao 2006 Study on antitumor effects of podophyllotoxin nanoliposome Chin J Chin Mater Med (in Chinese) 31 2 148 150
18. K. Sawant S. Dodiya 2008 Recent advances and patents on solid lipid nanoparticles Recent Patents Drug Deliv Formul 2 2 120 135
19. E. Elisabetta F. Martina M. Matteo D. Markus P. Lydia M. Paolo S. Elisa L. Francesco M. Enea M. Michele C. Rita 2008 Solid Lipid nanoparticles as delivery systems for bromocriptine Pharm Res 25 7 1521 1530
20. M. Gasco 2007 Lipid nanoparticles: Perspectives and challenges Adv Drug Deliver Rev 59 6 377 378