Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 6, 2008, Pages 831-834

  Yu, Peng Fei ^a,b   Chen, Hong ^b   Wang, Jing ^b   He, Chun Xian ^a   Cao, Bo ^b   Li, Min ^b   Yang, Na ^a   Lei, Zhi Yong ^b   Cheng, Mao Sheng ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Cytotoxicity; Indibulin; Multidrug resistance; Podophyllotoxin

Indexed keywords

4ALPHA [[1 (3,4 DICHLOROBENZYL)INDOL 3 YL]GLYOXYL]PODOPHYLLOTOXIN; 4ALPHA [[1 (4 CHLOROBENZYL)INDOL 3 YL]GLYOXYL]PODOPHYLLOTOXIN; 4ALPHA [[1 (BENZO[1,3]DIOXOL 5 YLMETHYL)INDOL 3 YL]GLYOXYL]PODOPHYLLOTOXIN; 4BETA [(2 METHYL INDOL 3 YL)GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [(26 METHOXY INDOL 3 YL)GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [(5 BROMO INDOL 3 YL)GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [(5 METHOXY INDOL 3 YL)GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [(6 FLUORO INDOL 3 YL)GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[1 (4 CHLOROBENZYL)INDOL 3 YL]GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [[1 (BENZO[1,3]DIOXOL 5 YLMETHYL)INDOL 3 YL]GLYOXYLAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA AMINO PODOPHYLLOTOXIN; CYTOTOXIC AGENT; DOXORUBICIN; INDIBULIN; INDOLE DERIVATIVE; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COMPARATIVE TOXICOLOGY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; COLORIMETRY; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PODOPHYLLOTOXIN; RHODAMINES; TETRAZOLIUM SALTS; THIAZOLES; TUBULIN;

EID: 45749149086     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.831     Document Type: Article

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