The synergy between structural stability and DNA-binding controls the antibody production in EPC/DOTAP/DOPE liposomes and DOTAP/DOPE lipoplexes

Colloids and Surfaces B: Biointerfaces

Volumn 73, Issue 2, 2009, Pages 175-184

  de la Torre, Lucimara Gaziola ^a   Rosada, Rogério Silva ^b   Trombone, Ana Paula Fávaro ^b   Frantz, Fabiani Gai ^b   Coelho Castelo, Arlete A M ^b   Silva, Celio Lopes ^b   Santana, Maria Helena Andrade ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cationic liposomes; Cytotoxicity; DNA delivery; DNA hsp65; Gene vaccine; Lipoplexes

Indexed keywords

ANTIBODY PRODUCTION; BIOLOGICAL BEHAVIOR; CATIONIC LIPOSOMES; COMPARATIVE STUDIES; CYTOTOXIC; DNA DELIVERY; DNA-BINDING; ELECTROSTATIC BINDING; GENE THERAPY; GENE VACCINE; HYDRODYNAMIC DIAMETER; IMMUNE RESPONSE; IMMUNOLOGICAL EFFECTS; IN-VITRO; IN-VIVO; LIPID CARRIERS; LIPOPLEXES; MELTING TEMPERATURES; NAKED DNA; PHYSICOCHEMICAL PROPERTY; SINGLE-DOSE; STRUCTURAL STABILITIES; SYNERGISTIC EFFECT;

ANTIBODIES; CHEMICAL PROPERTIES; CYTOTOXICITY; DNA; DRUG THERAPY; FLUID DYNAMICS; GENES; GENETIC ENGINEERING; LIPOSOMES; MELTING POINT; PHOSPHOLIPIDS; STABILITY; VACCINES; ZETA POTENTIAL;

NUCLEIC ACIDS;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; HEAT SHOCK PROTEIN 65; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; LIPOPLEX; LIPOSOME; NAKED DNA; PHOSPHATIDYLCHOLINE; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BCG VACCINATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA IMMUNIZATION; GENE DELIVERY SYSTEM; GENE THERAPY; GENETIC IMMUNIZATION; HYDRODYNAMICS; IMMUNOMODULATION; MELTING POINT; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SURFACE PROPERTY; ZETA POTENTIAL;

ANIMALS; ANTIBODY FORMATION; BACTERIAL PROTEINS; CATIONS; CELL DEATH; CHAPERONIN 60; DNA; DNA PROBES; DRUG CARRIERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACIDS, MONOUNSATURATED; FLUORESCENCE; LIPOSOMES; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; PHASE TRANSITION; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS; TRANSITION TEMPERATURE; TUBERCULOSIS VACCINES; VACCINES, DNA;

EID: 68649103693     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2009.05.013     Document Type: Article

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