A new synthetic compound, 2-OH, enhances interleukin-2 and interferon-γ gene expression in human peripheral blood mononuclear cells

Molecules

Volumn 14, Issue 7, 2009, Pages 2345-2355

  Chou, Shiu Huey ^a   Chou, Shang Shing P ^a   Liew, Yih Fong ^a   Leu, Jyh Yih ^a   Wang, Su Jane ^b   Huang, Rwei Fen S ^a   Tzeng, Woan Fang ^a   Kuo, Yuh Chi ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

2 OH; IL 2; PBMC; Proliferation

Indexed keywords

6 HYDROXY 2 TOSYLISOQUINOLIN 1(2H) ONE; 6-HYDROXY-2-TOSYLISOQUINOLIN-1(2H)-ONE; GAMMA INTERFERON; IMMUNOLOGIC FACTOR; INTERLEUKIN 2; QUINOLONE DERIVATIVE;

ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; MONONUCLEAR CELL; SYNTHESIS;

CELL PROLIFERATION; GENE EXPRESSION; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; QUINOLONES;

EID: 68649095951     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14072345     Document Type: Article

References (24)

1. Numata, A.; Ibuka, I. Alkaloids from ants and other insects. In The Alkaloids; Brossi, A., Ed.; Academic Press: New York, NY, USA, 1987; p. 193.
2. Liu, C.P.; Tsai, W.J.; Lin, Y.L.; Liao, J.F.; Chen, C.F.; Kuo, Y.C. The extracts from Nelumbo nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci. 2004, 75, 699-716.
3. Liu, C.P.; Kuo, Y.C.; Lin, Y.L.; Liao, J.F.; Shen, C.C.; Chen, C.F.; Tsai, W.J. (S)-Armepavine inhibits human peripheral blood mononuclear cells activation by regulating Itk and PLC? activation in a PI3K-dependent manner. J. Leukocyte Biol. 2007, 81, 1276-1286.
4. Liu, C.P.; Tsai, W.J.; Lin, Y.L.; Liao, J.F.; Shen, C.C.; Chen, C.F.; Kuo, Y.C. Inhibitory effects of (S)-armepavine from Nelumbo nucifera on autoimmune disease of MRL lpr/lpr mice. Eur. J. Pharmacol. 2006, 531, 270-279.
5. San Miguel, J.F.; Schlag, R.; Khuageva, N.K.; Dimopoulos, M.A.; Shpilberg, O.; Kropff, M. Spicka, I.; Petrucci, M.T.; Palumbo, A.; Samoilova, O.S.; Dmoszynska, A.; Abdulkadyrov, K.M.; Schots, R.; Jiang, B.; Mateos, M.V.; Anderson, K.C.; Esseltine, D.L.; Liu, K.; Cakana, A.; Van De Velde, H.; Richardson, P.G. VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N. Engl. J. Med. 2008, 359, 906-917.
6. Chou, S.S.P.; Chen, P.W. Cycloaddition reactions of 4-sulfur-substituted dihydro-2-pyridones and 2-pyridones with conjugated dienes. Tetrahedron 2008, 64, 1879-1887.
7. Lewis, R.S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001, 19, 497-521.
8. kB in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogen stimuli, but not to abnormal thymopoiesis. J. Immunol. 1999, 162, 6442-6450.
9. Robb, R.J. Interleukin-2: the molecule and its function. Immunol. Today 1984, 5, 203-209.
10. Young, H.A. Regulation of interferon-gamma gene expression. J. Interf. Cytok. Res. 1996, 16, 563-568.
11. Cantrell, D. T cell antigen receptor signal transduction pathways. Ann. Rev. Immunol. 1996, 14, 259-274. (Pubitemid 26130185)
12. Kuo, Y.C.; Yang, N.S.; Chou, C.J.; Lin, L.C.; Tsai, W.J. Regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human T lymphocytes by piperlactam S isolated from Piper kadsura. Mol. Pharamcol. 2000, 58, 1057-1066.
13. kB transcription factors. Brit. J. Pharmacol. 2007, 150, 298-312.
14. Charles, A.J., Jr.; Paul, T.; Hunt, S.; Walport, M. Immunobiology. Current Biology Ltd: New York, NY, USA, 1997.
15. Kuby, J. Immunology. W.H. Freeman and Company: New York, NY, USA, 1997; pp. 285-310.
16. Chen, Y.C.; Chang, S.C.; Wu, M.H.; Chuang, K.A.; Wu, J.Y.; Tsai, W.J.; Kuo Y.C. Norcantharidin reduced cyclins and cytokines production in human peripheral blood mononuclearcells. Life Sci. 2009, 84, 218-226.
17. Ajchenbaum, F.; Ando, K.; DeCaprio, J.A.; Griffin, J.D. Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes. J. Biol. Chem. 1993, 268, 4113-4119.
18. Janeway, C.A.; Travers, P.; Hunt, S.; Walport, M. Immunobiology: The immune system in health and disease. Garland Publishing Inc: New York, NY, USA, 1997; pp. 1:1-1:26.
19. Wang, S.J.; Chou, S.H.; Kuo, Y.C.; Chou, S.S. P.; Tzeng, W.F.; Leu, C.Y.; Huang, R.F. S.; Liew, Y.F. HDT-1, a new synthetic compound, inhibits glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Acta Pharmacol. Sin. 2008, 29, 1289-1295.
20. Wu, M.H.; Tsai, W.J.; Don, M.J.; Chen, Y.C.; Kuo, Y.C. Tanshinlactone A from Salvia miltiorrhiza modulates interleukin-2 and interferon-γ gene expression. J. Ethnopharmacol. 2007, 113, 210-217.
21. Kuo, Y.C.; Weng, S.C.; Chou, C.J.; Chang, T.T.; Tsai, W.J. Activation and proliferation signals in primary human T lymphocytes inhibited by ergosterol peroxide isolated from Cordyceps cicadae. Bri. J. Pharmacol. 2003, 140, 895-906.
22. Tsai, W.J.; Chen, Y.C.; Wu, M.H.; Lin, L.C.; Chuang, K.A.; Chang, S.C.; Kuo, K.C. Seselin from Plumbago zeylanica inhibits phytohemagglutinin (PHA)-stimulated cell proliferation in human peripheral blood mononuclear cells. J. Ethnopharmacol. 2008, 119, 67-73.
23. Taniguchi, T. Structure and function of IL-2 and IL-2 receptors. Behring Inst. Mitt. 1992, 91, 87- 95.
24. Gray, P.W.; Goeddel, D.V. Structure of the human immune interferon gene. Nature. 1982, 298, 859-863.