Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody

British Journal of Pharmacology

Volumn 157, Issue 2, 2009, Pages 281-293

  Pullen, N ^a,e   Molloy, E ^b   Carter, D ^a   Syntin, P ^c   Clemo, F ^d   Finco Kent, D ^d   Reagan, W ^d   Zhao, S ^d   Kawabata, T ^d   Sreckovic, S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b High Wycombe Bucks   (United Kingdom)

^c NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^e PFIZER INC   (United States)

Author keywords

Inflammatory bowel disease; Leukocyte homing; Madcam; MECA 367; PF 00547659; PK PD

Indexed keywords

GLYCOPROTEIN; MECA 367; MONOCLONAL ANTIBODY; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE; PF 00547659; UNCLASSIFIED DRUG; PRIMER DNA;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CROSS REACTION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MACACA; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; ANIMAL; CELL STRAIN 3T3; CHO CELL; CRICETULUS; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HAMSTER; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURFACE PLASMON RESONANCE; T LYMPHOCYTE;

3T3 CELLS; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CHO CELLS; CRICETINAE; CRICETULUS; CROSS REACTIONS; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; MACACA FASCICULARIS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURFACE PLASMON RESONANCE; T-LYMPHOCYTES;

EID: 68549135114     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00137.x     Document Type: Article

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