17β-Nitro-5α-androstan-3α-ol and its 3β-methyl derivative: Neurosteroid analogs with potent anticonvulsant and anxiolytic activities

European Journal of Pharmacology

Volumn 617, Issue 1-3, 2009, Pages 68-73

  Runyon, Scott P ^a   Orr, Matthew ^a   Navarro, Hernán A ^a   Kepler, John A ^a   Rogawski, Michael A ^b   Kaminski, Rafal M ^c   Cook, C Edgar ^a  

^a RTI INTERNATIONAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Allopregnanolone; Anticonvulsant; Anxiolytic; Bioisostere; GABAA receptor; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 17BETA NITRO 5ALPHA ANDROSTANE; 3ALPHA HYDROXY 3BETA METHYL 17BETA NITRO 5ALPHA ANDROSTANE; 3ALPHA HYDROXY 3BETA METHYL NITRO 5ALPHA ANDROSTANE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA ANDROSTANEDIOL; 3BETA HYDROXY 17BETA NITRO 5ALPHA ANDROSTANE; 3BETA HYDROXY 3ALPHA METHYL 17BETA NITRO 5ALPHA ANDROSTANE; 3BETA HYDROXY 3ALPHA METHYL 5ALPHA ANDROSTAN 17 OXIME; 3BETA HYDROXY 5ALPHA ANDROSTAN 17 OXIME; 4 AMINOBUTYRIC ACID A RECEPTOR; ANDROSTANEDIOL; ELTANOLONE; FLUNITRAZEPAM; GANAXOLONE; NEUROSTEROID; PENTETRAZOLE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE S 35; TRITIUM; UNCLASSIFIED DRUG; ANDROSTAN 3 OL; ANDROSTAN-3-OL; ANDROSTANE DERIVATIVE; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; LIGAND;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DISEASE MODEL; DRUG POTENCY; DRUG STRUCTURE; EPILEPSY; EPIMERIZATION; EXPERIMENTAL MODEL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY; ANIMAL; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT;

ALLOSTERIC REGULATION; ANDROSTANOLS; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MALE; MICE; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 68549122496     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.052     Document Type: Article

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