Pharmacological properties of ATP-sensitive purinergic receptors expressed in human G292 osteoblastic cells

European Journal of Pharmacology

Volumn 617, Issue 1-3, 2009, Pages 12-16

  Li, Dong Liang ^a,b   Liu, Xing ^a   Xia, Rong ^a   Ross, Claire ^a   Yang, Xuebin ^a   Jiang, Lin Hua ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

G292 cell; Intracellular Ca2+; P2X; P2Y; Receptor agonist; Receptor antagonist

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENOSINE DERIVATIVE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BRILLIANT BLUE; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; TRINITROPHENYL; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; METALS, HEAVY; OSTEOBLASTS; PURINERGIC P2 RECEPTOR AGONISTS; PURINERGIC P2 RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2;

EID: 68549107564     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.06.049     Document Type: Article

References (32)

1. Bo X., Jiang L.H., Wilson H.L., Kim M., Burnstock G., Surprenant A., and North R.A. Pharmacological and biophysical properties of the human P2X5 receptor. Mol. Pharmacol. 63 (2003) 1407-1416
2. Buckley K.A., Hipskind R.A., Gartland A., Bowler W.B., and Gallagher J.A. Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand. Bone 31 (2002) 582-590
3. Ciana P., Fumagalli M., Trincavelli M.L., Verderio C., Rosa P., Lecca D., Ferrario S., Parravicini C., Capra V., Gelosa P., Guerrini U., Belcredito S., Cimino M., Sironi L., Tremoli E., Rovati G.E., Martini C., and Abbracchio M.P. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 25 (2006) 4615-4627
4. Dziak R., Yang B.M., Leung B.W., Li S., Marzec N., Margarone J., and Bobek L. Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. Prostaglandins Leukot. Essent. Fatty Acids 68 (2003) 239-249
5. Egan T.M., and Khakh B.S. Contribution of calcium ions to P2X channel responses. J Neurosci 24 (2004) 3413-3420
6. Garcia-Guzman M., Stühmer W., and Soto F. Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. Brain Res. Mol. Brain Res. 47 (1997) 59-66
7. Garcia-Guzman M., Soto F., Gomez-Hernandez J.M., Lund P.E., and Stühmer W. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol. 51 (1997) 109-118
8. Genetos D.C., Geist D.J., Liu D., Donahue H.J., and Duncan R.L. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J. Bone. Miner. Res. 20 (2005) 41-49
9. Hoebertz A., Meghji S., Burnstock G., and Arnett T.R. Extracellular ADP is a powerful osteolytic agent: Evidence for signaling through the P2Y(1) receptor on bone cells. FASEB J. 15 (2001) 1139-1148
10. Hoebertz A., Mahendran S., Burnstock G., and Arnett T.R. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: A novel role for the P2Y2 receptor in bone remodeling. J. Cell Biochem. 86 (2002) 413-419
11. Hoebertz A., Arnett T.R., and Burnstock G. Regulation of bone resorption and formation by purines and pyrimidines. Trends Pharmacol. Sci. 24 (2003) 290-297
12. Jiang L.H., Mackenzie A.B., North R.A., and Surprenant A. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol. Pharmacol. 58 (2000) 82-88
13. Ke H.Z., Qi H., Weidema A.F., Zhang Q., Panupinthu N., Crawford D.T., Grasser W.A., Paralkar V.M., Li M., Audoly L.P., Gabel C.A., Jee W.S., Dixon S.J., Sims S.M., and Thompson D.D. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol. Endocrinol. 17 (2003) 1356-1367
14. Khakh B.S., Proctor W.R., Dunwiddie T.V., Labarca C., and Lester H.A. Allosteric control of gating and kinetics at P2X(4) receptor channels. J. Neurosci. 19 (1999) 7289-7299
15. Khakh B.S., and North R.A. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442 (2006) 527-532
16. Li J., Sukumar P., Milligan C.J., Kumar B., Ma Z.Y., Munsch C.M., Jiang L.H., Porter K.E., and Beech D.J. Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circ Res. 103 (2008) e97-e104
17. Liu D., Genetos D.C., Shao Y., Geist D.J., Li J., Ke H.Z., Turner C.H., and Duncan R.L. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 42 (2008) 644-652
18. Lynch K.J., Touma E., Niforatos W., Kage K.L., Burgard E.C., van Biesen T., Kowaluk E.A., and Jarvis M.F. Molecular and functional characterization of human P2X(2) receptors. Mol. Pharmacol. 56 (1999) 1171-1181
19. Jung S., Mühle A., Schaefer M., Strotmann R., Schultz G., and Plant T.D. Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem. 278 (2003) 3562-3571
20. Nakamura E., Uezono Y., Narusawa K., Shibuya I., Oishi Y., Tanaka M., Yanagihara N., Nakamura T., and Izumi F. ATP activates DNA synthesis by acting on P2X receptors in human osteoblast-like MG-63 cells. Am. J. Physiol. Cell Physiol. 279 (2000) C510-C519
21. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82 (2002) 1013-1067
22. North R.A., and Surprenant A. Pharmacology of cloned P2X receptors. Annu. Rev. Pharmacol. Toxicol. 40 (2000) 563-580
23. Orriss I.R., Knight G.E., Ranasinghe S., Burnstock G., and Arnett T.R. Osteoblast responses to nucleotides increase during differentiation. Bone 39 (2006) 300-309
24. Panupinthu N., Zhao L., Possmayer F., Ke H.Z., Sims S.M., and Dixon S.J. P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J. Biol. Chem. 282 (2007) 3403-3412
25. Rassendren F., Buell G.N., Virginio C., Collo G., North R.A., and Surprenant A. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem. 272 (1997) 5482-5486
26. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50 (1998) 413-492
27. Tatakis D.N., Dolce C., Hagel-Bradway S.E., and Dziak R. Second messenger systems stimulated by bradykinin in osteoblastic cells: Evidence for B2 receptors. Bone Miner. 18 (1992) 1-14
28. Vihinen P., Riikonen T., Laine A., and Heino J. Alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. Cell Growth Differ. 7 (1996) 439-447
29. Virginio C., Robertson G., Surprenant A., and North R.A. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol. Pharmacol. 53 (1998) 969-973
30. von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol. Ther. 110 (2006) 415-432
31. You J., Jacobs C.R., Steinberg T.H., and Donahue H.J. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J. Biol. Chem. 277 (2002) 48724-48729
32. Zhang W., Dziak R.M., and Aletta J.M. EGF-mediated phosphorylation of extracellular signal-regulated kinases in osteoblastic cells. J. Cell Physiol. 162 (1995) 348-358