Relative growth hormone deficiency and cortisol excess are associated with increased cardiovascular risk markers in obese adolescent girls

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 8, 2009, Pages 2864-2871

  Russell, M ^a,b   Bredella, M ^a   Tsai, P ^a   Mendes, N ^a   Miller, K K ^a   Klibanski, A ^a   Misra, Madhusmita ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GROWTH HORMONE RELEASING FACTOR; HYDROCORTISONE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR RISK; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FAT NECROSIS; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; OBESITY; PRIORITY JOURNAL; SCHOOL CHILD; URINALYSIS;

EID: 68549083425     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0380     Document Type: Article

References (39)

1. Ross R 1999 Atherosclerosis: an inflammatory disease. N Engl J Med 340:115-126
2. Willerson JT, Ridker PM 2004 Inflammation as a cardiovascular risk factor. Circulation 109:II2-I10
3. Freedman DS, Newman 3rd WP, Tracy RE, Voors AE, Srinivasan SR, Webber LS, Restrepo C, Strong JP, Berenson GS 1988 Black-white differences in aortic fatty streaks in adolescence and early adulthood: the Bogalusa Heart Study. Circulation 77:856-864
4. McGill Jr HC, McMahan CA, Herderick EE, Malcom GT, Tracy RE, Strong JP 2000 Origin of atherosclerosis in childhood and adolescence. Am J Clin Nutr 72:1307S-1315S
5. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S 2004 Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 350:2362-2374
6. Utz AL, Yamamoto A, Hemphill L, Miller KK 2008 Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women. J Clin Endocrinol Metab 93:2507-2514
7. Lear SA, Humphries KH, Kohli S, Frohlich JJ, Birmingham CL, Mancini GB 2007 Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT). Stroke 38:2422-2429
8. Grundy SM 2007 Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab 92:399-404
9. Misra M, Bredella MA, Tsai P, Mendes N, Miller KK, Klibanski A 2008 Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls. Am J Physiol Endocrinol Metab 295:E385-E392
10. Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S 2006 Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome. J Clin Endocrinol Metab 91:4415-4423
11. Beauregard C, Utz AL, Schaub AE, Nachtigall L, Biller BM, Miller KK, Klibanski A 2008 Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study. J Clin Endocrinol Metab 93:2063-2071
12. Roemmich JN, Huerta MG, Sundaresan SM, Rogol AD 2001 Alterations in body composition and fat distribution in growth hormone-deficient prepubertal children during growth hormone therapy. Metabolism 50:537-547
13. Weigensberg MJ, Toledo-Corral CM, Goran MI 2008 Association between the metabolic syndrome and serum cortisol in overweight Latino youth. J Clin Endocrinol Metab 93:1372-1378
14. Albiger N, Testa RM, Almoto B, Ferrari M, Bilora F, Petrobelli F, Pagnan A, Mantero F, Scaroni C 2006 Patients with Cushing's syndrome have increased intimal media thickness at different vascular levels: comparison with a population matched for similar cardiovascular risk factors. Horm Metab Res 38:405-410
15. Faggiano A, Pivonello R, Spiezia S, De Martino MC, Filippella M, Di Somma C, Lombardi G, Colao A 2003 Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab 88:2527-2533
16. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB 2004 Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291:1730-1737
17. Greulich W, Pyle S 1959 Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford, CA: Stanford University Press
18. Lee JM, Appugliese D, Kaciroti N, Corwyn RF, Bradley RH, Lumeng JC 2007 Weight status in young girls and the onset of puberty. Pediatrics 119:e624-e630
19. Faria AC, Bekenstein LW, Booth Jr RA, Vaccaro VA, Asplin CM, Veldhuis JD, Thorner MO, Evans WS 1992 Pulsatile growth hormone release in normal women during the menstrual cycle. Clin Endocrinol (Oxf) 36:591-596
20. Aimaretti G, Baffoni C, Bellone S, Di Vito L, Corneli G, Arvat E, Benso L, Camanni F, Ghigo E 2000 Retesting young adults with childhood-onset growth hormone (GH) deficiency with GH-releasing-hormone-plus-arginine test. J Clin Endocrinol Metab 85:3693-3699
21. Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML 2002 Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067-2079
22. Nass R, Thorner MO 2002 Impact of the GH-cortisol ratio on the age-dependent changes in body composition. Growth Horm IGF Res 12:147-161
23. Maccario M, Grottoli S, Aimaretti G, Gianotti L, Endrio Oleandri S, Procopio M, Savio P, Tassone F, Ramunni J, Camanni F, Ghigo E 1999 IGF-1 levels in different conditions of low somatotrope secretion in adulthood: obesity in comparison with GH deficiency. Minerva Endocrinol 24:57-61
24. Weltman A, Despres JP, Clasey JL, Weltman JY, Wideman L, Kanaley J, Patrie J, Bergeron J, Thorner MO, Bouchard C, Hartman ML 2003 Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults. Metabolism 52:73-80
25. Stein EA 2008 Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: more clarity or confusion? J Am Coll Cardiol 52:2206-2209
26. Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL 2004 Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation 109:IV6-IV19
27. Ridker PM, Hennekens CH, Buring JE, Rifai N 2000 C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843
28. Copeland KC, Colletti RB, Devlin JT, McAuliffe TL 1990 The relationship between insulin-like growth factor-I, adiposity, and aging. Metabolism 39:584-587
29. Hochberg Z, Hertz P, Colin V, Ish-Shalom S, Yeshurun D, Youdim MB, Amit T 1992 The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-I (IGF-I), and IGF-I receptors in obesity and anorexia nervosa. Metabolism 41:106-112
30. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rossetto R, Savio P, Aimaretti G, Camanni F, Ghigo E 1999 Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disord 23:612-618
31. Mårin P, Kvist H, Lindstedt G, Sjöström L, Björntorp P 1993 Low concentrations of insulin-like growth factor-I in abdominal obesity. Int J Obes Relat Metab Disord 17:83-89
32. Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB 1997 Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord 21:355-359
33. Dietz J, Schwartz J 1991 Growth hormone alters lipolysis and hormone-sensitive lipase activity in 3T3-F442A adipocytes. Metabolism 40:800-806
34. Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N 2006 Long-term IGF-I treatment of children with Laron syndrome increases adiposity. Growth Horm IGF Res 16:61-64
35. Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N 2006 Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol (Oxf) 65:114-117
36. Klöting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, Blüher M 2008 Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes 57:2074-2082
37. McGrath S, Morris M, Bouloux PM 1999 Growth hormone deficiency and atherosclerosis: is there a link? Growth Horm IGF Res 9(Suppl A):9-13
38. Agha A, Monson JP 2007 Modulation of glucocorticoid metabolism by the growth hormone-IGF-1 axis. Clin Endocrinol (Oxf) 66:459-465
39. Sen Y, Aygun D, Yilmaz E, Ayar A 2008 Children and adolescents with obesity and the metabolic syndrome have high circulating cortisol levels. Neuro Endocrinol Lett 29:141-145