Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization

Science

Volumn 325, Issue 5941, 2009, Pages 760-764

  Pernía Andrade, Alejandro J ^a,j   Kato, Ako ^a,i   Witschi, Robert ^a,i   Nyilas, Rita ^b   Katona, István ^b   Freund, Tamás F ^b   Watanabe, Masahiko ^c   Filitz, Jörg ^d   Koppert, Wolfgang ^d,k   Schüttler, Jürgen ^d   Ji, Guangchen ^e   Neugebauer, Volker ^e   Marsicano, Giovanni ^f   Lutz, Beat ^g   Vanegas, Horacio ^h   Zeilhofer, Hanns Ulrich ^a,i  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e University of Texas Medical Branch School of Medicine   (United States)

^f INSTITUT FRANÇOIS MAGENDIE   (France)

^g JOHANNES GUTENBERG UNIVERSITY   (Germany)

^h INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

ⁱ ETH ZURICH   (Switzerland)

^j UNIVERSITY OF FREIBURG   (Germany)

^k HANNOVER MEDICAL SCHOOL   (Germany)

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Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; GLYCINE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; RIMONABANT;

ANESTHETIC; INHIBITION; NERVOUS SYSTEM;

ARTICLE; BRAIN NERVE CELL; HUMAN; INTERNEURON; MUSCLE SPINDLE AFFERENT NERVE; NEUROTRANSMISSION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD DORSAL HORN; STUDENT T TEST; ADULT; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG ANTAGONISM; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HYPERALGESIA; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; METABOLISM; MOUSE; NERVE CELL INHIBITION; NONMYELINATED NERVE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTERIOR HORN CELL; RAT; SPINAL CORD; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

ADULT; ANIMALS; ELECTRIC STIMULATION; ENDOCANNABINOIDS; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HUMANS; HYPERALGESIA; INHIBITORY POSTSYNAPTIC POTENTIALS; INTERNEURONS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE FIBERS, UNMYELINATED; NEURAL INHIBITION; PAIN; PIPERIDINES; POSTERIOR HORN CELLS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; SPINAL CORD; SYNAPTIC TRANSMISSION; YOUNG ADULT;

EID: 68449087610     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1171870     Document Type: Article

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26. This research was supported in part by grants from the Schweizerischer National Fonds to H.U.Z. (3100A0-116064/1), from the Deutsche Forschungsgemeinschaft to W.K. (KO 1878/2-2) and H.U.Z. (ZE 377/8-2), from NIH (NS38261 and NS11255) to V.N., from the European Union (LSHM-CT-2004-005166) to T.F.F., and from the OTKA (F046407) and ETT (561/2006) to I.K. A.J.P.A. was supported partly by scholarships from the German DAAD and the Venezuelan FONACIT for graduate study at IVIC. I.K. was supported by a Ja'nos Bolyai scholarship. The authors thank R. Kuner and C. V. Wright for providing sns-cre and ptf1a-cre mice, respectively; J.-M. Fritschy, H. Handwerker, H. Möhler, and M. Schmelz for critical reading of the manuscript; T. Müller for very valuable suggestions; and I. Camenisch and L. Scheurer for genotyping of the mice.