Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6)

Human Molecular Genetics

Volumn 7, Issue 3, 1998, Pages 517-524

  Merriman, Tony R ^a   Eaves, Iain A ^a   Twells, Rebecca C J ^a   Merriman, Marilyn E ^a   Danoy, Patrick A C ^a   Muxworthy, Claire E ^a   Hunter, Kara M D ^a   Cox, Roger D ^a   Cucca, Francesco ^a   McKinney, Patricia A ^b   Shield, Julian P H ^c   Baum, J David ^c   Tuomilehto, Jaakko ^d   Tuomilehto Wolf, Eva ^d   Ionesco Tirgoviste, C ^e   Joner, Geir ^f   Thorsby, Erik ^g   Undlien, Dag E ^g   Pociot, Flemming ^h   Nerup, Jørn ^h   Rønningen, Kjersti S ⁱ   Bain, Steve C ^j   Todd, John A ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e Nutrition and Metabolic Diseases 'N Paulescu'   (Romania)

^f AKER UNIVERSITY HOSPITAL   (Norway)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

^h STENO DIABETES CENTER   (Denmark)

ⁱ NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^j UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA MARKER; MICROSATELLITE DNA;

ARTICLE; CHROMOSOME 18Q; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HETEROZYGOTE; HUMAN; INHERITANCE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

CHILD; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 18; DIABETES MELLITUS, TYPE 1; DISEASE SUSCEPTIBILITY; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; HAPLOTYPES; HUMANS; MALE; MICROSATELLITE REPEATS; NUCLEAR FAMILY; PEDIGREE; POLYMERASE CHAIN REACTION;

EID: 6844241972     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/7.3.517     Document Type: Article

References (41)

1. Davies, J.L., Kawaguchi, Y., Bennett, S.T., Copeman. J.B., Cordell, H.J., Pritchard, L.E., Reed, P.W., Gough, S.C.L., Jenkins, S.C., Palmer, S.M., Balfour, K.M., Rowe, B., Farrall, M., Barnett, A.H., Bain. S.C. and Todd, J.A. (1994) A genome-wide search for human type I diabetes susceptibility genes. Nature, 371, 130-136.
2. Daniels, S.E., Bhattacharrya, S., James, A., Leaves, N.I., Young. A., Hill, M.R., Faux, J.A., Ryan, G.F., le Söuef, P.N., Lathrop, G.M., Musk, A.W. and Cookson, W.O.C.M. (1996) A genome-wide search for quantitative trait loci underlying asthma. Nature, 383, 247-250.
3. Ebers, G.C., Kukay, K., Bulman, D.E., Sadovnick, A.D., Rice. G., Anderson, C., Armstrong, H., Cousin K., Bell, R.B., Hader, W., Paty, D.W., Hashimoto, S., Oger, J., Duquette, P., Warren, S., Gray, T., O'Connor, P., Nath, A., Auty, A., Metz. L., Francis. G., Paulseth, J.E., Murray, T.J., Pryse-Phillips, W., Nelson, R., Freedman, M., Brunet, D., Bouchard, J.-P., Hinds, D. and Risch, N. (1996) A full genome search in multiple sclerosis. Nature Genet., 13, 472-476.
4. Hanis, C.L., Boerwinkle, E., Chakraborty. R., Ellsworth. D.L., Concannon, P., Striling, B., Morrison, V.A., Wapelhorst, B., Spielman, R.S., Gogolin-Ewens, K.J., Shephard, J.M., Williams, S.R., Risch, N., Hinds, D., Iwasaki, N., Ogata, M., Omori, Y., Petzold, C., Rietzish, H., Schroder, H.-E., Schulze, J., Cox, N.J., Menzel, S., Boriraj, V.V., Chen, X., Lim, L.R., Lindner, T., Mereu, L.E., Wang, Y.-Q., Xiang. K., Yamagata, K., Yang, Y. and Bell, G.I. (1996) A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genet., 13, 161-167.
5. Hashimoto, L., Habita. C., Beressi, J.P., Delepine, M., Besse, C., Cambon-Thomsen, A., Deschamps, I., Rotter, J.I., Djoulah, S., James, M.R., Froguel, P., Weissenbach, J., Lathrop, G.M. and Julier, C. (1994) Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature, 371, 161-164.
6. Mahtani, M.M., Widén, E., Lehto, M., Thomas, J., McCarthy, M., Brayer, J., Bryant, B., Chan, G., Daly, M., Forsblom, C., Kanninen, T., Kirby, A., Kruglyak. L., Munnelly, K., Parkkonen, M., Reeve-Daly, M.P., Weaver, A., Brettin, T., Duyk, G., Lander. E.S. and Groop, L.C. (1996) Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Genet., 14, 90-94.
7. Satsangi, J, Parkes M., Louis, E., Hashimoto, L., Kato, N., Welsh, K., Terwilliger, J.D., Lathrop, G.M., Bell, J.I. and Jewell, D.P. (1996) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3. 7 and 12. Nature Genet., 14, 199-202.
8. Sawcer, S., Jones, H.B., Feakes, R., Gray, J., Smaldon, N., Chataway, J., Robertson, N., Clayton, D., Goodfellow, P.N. and Compston, A. (1996) A genome screen in multiple sclerosis. Nature Genet., 13, 464-468.
9. The Multiple Sclerosis Genetics Group (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genet., 13, 469-471.
10. Trembath, R.C., Clough, R.L. Rosbotham, J.L., Jones, A.B., Camp, R.D.R., Frodsham, A., Browne, J., Barber, R., Terwilliger, J., Lathrop, G.M. and Barker, J.N.W.N. (1997) Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by two stage genome-wide search in psoriasis. Hum. Mol. Genet., 6, 813-820.
11. Nair, R.P., Henseler, T., Jenisch, S., Stuart, S., Bichakjian, C.K., Lenk, W., Westphal, E., Guo, S.-W., Christophers, E., Voorhees, J.J. and Elder, J.T. (1997) Evidence for two psoriasis susceptibility loci (HLA and I7q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum. Mol. Genet., 6, 1349-1356.
12. Davies, J.L., Cucca, F., Goy, J.V., Atta, Z.A.A., Merriman, M.E., Wilson, A., Barnett, A.H., Bain, S.C. and Todd, J.A. (1996) Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. Hum. Mol. Genet., 5. 1071-1074.
13. Luo, D.F., Buzzetti, R., Rotter, J.I.. Maclaren, N.K., Raffel, L.J., Nistico, L., Giovannini, C., Pozzilli, P., Thomson, G. and She, J.-X. (1996) Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. Hum. Mol. Genet., 5, 693-698.
14. Kruglyak, L. and Lander, E.S. (1995) High-resolution genetic mapping of complex traits. Am. J. Hum. Genet., 56, 1212-1223.
15. Lander, E.S. and Schork, N.J. (1994) Genetic dissection of complex traits. Science, 265, 2037-2048.
16. Copeman, J.B., Cucca, F., Heame, C.M., Comall, R.J., Reed, P.W., Rønningen, K.S., Undlien, D.E., Nisticò, L., Buzzetli, R., Tosi, R., Pociot, F., Nerup, J., Cornélis, F., Barnett, A.H., Bain, S.C. and Todd, J.A. (1995) Linkage disequilibrium mapping of a type I diabetes susceptibility gene (IDDM7) to human chromosome 2q31-q33. Nature Genet., 9, 80-85.
17. Risch, N. and Merikangas, K. (1996) The future of genetic studies in complex disease. Science, 273, 1516-1517.
18. Devlin, B., Risch, N. and Roeder, K. (1996) Disequilibrium mapping: composite likelihood for linkage disequilibrium. Genomics, 36, 1-16.
19. Xiong, M. and Guo, S.W. (1997) Fine-scale genetic mapping based on linkage disequilibrium: theory and applications. Am. J. Hum. Genet., 60, 1513-1531.
20. Jorde, L.B., Watkins, W.S., Carlson, M., Groden, J., Albertsen, H., Thliveris, A. and Leppert, M. (1994) Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am. J. Hum. Genet., 54, 884-898.
21. Hästbacka, J., de la Chapelle, A., Mahtani, M.M., Clines, G., Reeve-Daly, M.P., Daly, M., Hamilton, B.A., Kusumi, K.,Trivedi, B., Weaver, A., Coloma, A., Lovett, M., Buckler, A., Kaitila, I. and Lander, E.S. (1994) The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell, 78, 1-20.
22. Terwilliger, J.D. (1995) A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am. J. Hum. Genet., 56, 777-787.
23. Feder, J.N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.A., Basava, A., Dormishian, F., Domingo, R.,Jr. Ellis, M.C., Fullan. A., Hinton, L.M., Jones, N.L., Kimmel, B.E., Kronmal, G.S., Lauer, P., Lee, V.K., Loeb, D.B., Mapa, F.A., McClelland, E., Meyer, N.C., Mintier, G.A., Moeller, N., Moore, T., Morikang, E., Prass, C.E., Quintana, L., Starnes, S.M., Schatzman, R.C., Brunke, K.J., Drayna, D.T., Risch, N.J., Bacon, B.R. and Wolff, R.K. (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet., 13, 399-408.
24. Lehesjoki, A.-E., Koskiniemi, M., Norio, R.,Tirrilo, S., Sistonen, P., Lander, E. and de la Chapelle, A. (1993) Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping. Hum. Mol. Genet., 2, 1229-1234.
25. Merriman, T., Twells, R., Merriman, M., Eaves, I., Cox, R., Cucca, F., McKinney, P., Shield, J., Baum, D., Bosi, E., Pozzilli, P., Nisticò, L., Buzzetti, R., Joner, G., Rønningen, K., Thorsby, E., Undlien, D., Pociot, F., Nerup, J., Bain, S., Barnett, A. and Todd. J. (1997) Evidence by allelic association dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. Hum. Mol. Genet., 6, 1003-1010.
26. Spielman, R., McGinnis, R. and Ewens, W. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet., 52, 506-516.
27. Nisticò, L., Buzzetti, R., Pritchard, L.E., Van der Auwera, B., Giovannini, C., Bosi, E., Larrad, M.T.M., Rios, M.S. Chow, C.C., Cockram, C.S., Jacobs, K., Mijovic, C., Bain, S.C., Barnett, A.H., Vandewalle, C.L., Schuit, F., Gorus, F.K., Belgian Diabetes Registry. Tosi, R., Pozzilli, P. and Todd, J.A. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type I diabetes. Hum. Mol. Genet., 5. 1075-1080.
28. Marron, M.P., Raffel, L.J., Garchon, H.-J., Jacob, C.O., Serrano-Rios, M., Larrad, M.T.M., Teng, W.-P., Park, Y., Zhang, Z.-X., Goldstein, D.R., Tao, Y.-W., Beaurain, G., Bach, J.-F., Huang, H.-S., Luo, D.-F., Zeidler, A., Rotter, J.I., Yang, M.C.K., Modilevsky, T., Maclaren, N. and She, J.-X. (1997) Insulin-dependent mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet., 6, 1275-1282.
29. Martin, E.R., Kaplan, N.L. and Weir, B.S. (1997) Tests for linkage and association in nuclear families, Am. J. Hum. Genet., 61, 439-448.
30. Devlin, B. and Risch, N. (1995) A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics, 29, 311-322.
31. Todd, J.A., Mijovic, C., Fletcher, J., Jenkins, D., Bradwell, A.R. and Barnett, A.H. (1989) Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature, 338, 587-589.
32. Degli-Esposti, M.A., Leaver, A.L., Christiansen, F.T., Witt, C.S., Abraham, L.J. and Dawkins, R.L. (1992) Ancestral haplotypes: conserved population MHC haplotypes. Hum. Immunol., 34, 242-252.
33. Lucassen, A.M., Julier, C., Beressi, J.-P., Boitard, C., Froguel, P., Lathrop, M. and Bell. J.I. (1993) Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nature Genet., 4, 305-310.
34. Doria, A., Lee, J., Warram, J.H. and Krolewski, A.S. (1996) Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene. Diabetologia, 39, 594-599.
35. Wadsworth, E.J.K., Shield, J.P.H., Hunt. L.P. and Baum, J.D. (1997) A case-control study of environmental factors associated with diabetes in the under 5s. Diabetic Med., 14, 390-396.
36. Lemmark, A., Ducat, L., Eisenbarth, G., Ott, J., Permutt, M.A., Rubenstein, P. and Spielman, R. (1990) Family cell lines available for research. Am. J. Hum. Genet., 47, 1028-1030.
37. Pociol, F., Norgaard, K., Hobolth, N., Andersen, O. and Nerup, J. (1993) A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. Diabetologia, 36, 870-875.
38. Tuomilehto, J., Luonarnaa, R., Tuomilehto-Wolf, E., Reunanen, A., Virtala, E., Kaprio, E.A. and Akerblom, H.K. (1992) Epidemiology of childhood diabetes mellitus in Finland - background of a nationwide study of type 1 (insulin-dependent) diabetes mellitus. The Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia, 35, 70-76.
39. Riley, J., Butler, R., Ogilvie, D., Finniear, R., Jenner, D., Powell, S., Anand, R., Smith, J.C. and Markham, A.F. (1990) A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acids Res., 18, 2887-2890.
40. Reed, P.W., Davies, J.L., Copeman, J.B., Bennett, S.T., Palmer, S.M., Pritchard, L.E., Gough, S.C.L., Kawaguchi, Y., Cordell, H.J., Balfour, K.M., Jenkins, S.C, Powell, E.E., Vignal, A. and Todd, J.A. (1994) Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nature Genet., 7, 390-395.
41. Spielman, R.S. and Ewens, W.J. (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am. J. Hum. Genet., 59, 983-989.