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0344593433
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The relation between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan
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V. DeGruttola, L. Dix, R. D'Aquila, D. Holder, A. Phillips, and M. Ait-Khaled The relation between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standarized data analysis plan Antivir Ther 5 2000 41 48 (Pubitemid 30261205)
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Baxter, J.7
Clevenbergh, P.8
Hammer, S.9
Harrigan, R.10
Katzenstein, D.11
Lanier, R.12
Miller, M.13
Para, M.14
Yerly, S.15
Zolopa, A.16
Murray, J.17
Patick, A.18
Miller, V.19
Castillo, S.20
Pedneault, L.21
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34547927815
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Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients
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C. De Mendoza, C. Garrido, A. Corral, G. Ramírez-Olivencia, I. Jiménez-Nacher, and N. Zahonero Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients AIDS Res Hum Retroviruses 23 2007 879 885 (Pubitemid 47267494)
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Soriano, V.8
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0034785429
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Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure
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V. Miller, and B. Larder Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure Antivir Ther 6 2001 25 44 (Pubitemid 32938761)
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Miller, V.1
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40549100332
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Overcoming resistance to existing therapies in HIV-infected patients: The role of new antiretroviral drugs
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C.F. Perno, G. Moyle, C. Tsoukas, W. Ratanasuwan, J. Gatell, and M. Schechter Overcoming resistance to existing therapies in HIV-infected patients: the role of new antiretroviral drugs J Med Virol 80 2008 565 576 (Pubitemid 351358551)
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35648950291
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Resistance to the HIV integrase inhibitor raltegravir: Analysis of protocol 005, a phase 2 study in patients with triple-class resistant HIV-1 infection
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Abstract 8
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D. Hazuda, M. Miller, B. Nguyen, and J. Zhao Resistance to the HIV integrase inhibitor raltegravir: analysis of protocol 005, a phase 2 study in patients with triple-class resistant HIV-1 infection [Abstract 8] 16th International HIV Drug Resistance Workshop Barbados, 12-16 june 2007
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16th International HIV Drug Resistance Workshop. Barbados, 12-16 june 2007
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Hazuda, D.1
Miller, M.2
Nguyen, B.3
Zhao, J.4
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34748860363
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Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
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DOI 10.1097/QAI.0b013e318157131c, PII 0012633420071001000001
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M. Markowitz, B. Nguyen, E. Gotuzzo, F. Mendo, W. Ratanasuwan, and C. Kovacs Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study J Acquir Immune Defic Syndr 46 2007 125 133 (Pubitemid 47482607)
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Kovacs, C.6
Prada, G.7
Morales-Ramirez, J.O.8
Crumpacker, C.S.9
Isaacs, R.D.10
Gilde, L.R.11
Wan, H.12
Miller, M.D.13
Wenning, L.A.14
Teppler, H.15
Baker, D.16
Bloch, M.17
Bodsworth, N.18
Cooper, D.19
Workman, C.20
Kovacs, C.21
Tsoukas, C.22
Afani, A.23
Perez, J.24
Cortes, J.25
Prada, G.26
Gotuzzo, E.27
Mendo, F.28
Ratanasuwan, W.29
Thitivichianlert, S.30
Brown, S.31
Crumpacker, C.32
Galpin, J.33
Hicks, C.34
Kumar, P.35
Lichtenstein, K.36
Little, S.37
Liporace, R.38
Markowitz, M.39
Morales-Ramirez, J.40
Santana-Bagur, J.41
Schwartz, R.42
Steigbigel, R.43
Tashima, K.44
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43749098454
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48-Week Results from BENCHMRK-1, a Phase III Study of Raltegravir in Patients Failing Antiretroviral Therapy (ART) with Triple-Class Resistant HIV-1
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for the BENCHMRK-1 Study Group [Abstract 788]
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D. Cooper, J. Gatell, J. Rockstroh, C. Katlama, P. Yeni, A. Lazzarin, et al. for the BENCHMRK-1 Study Group 48-Week Results from BENCHMRK-1, a Phase III Study of Raltegravir in Patients Failing Antiretroviral Therapy (ART) with Triple-Class Resistant HIV-1 [Abstract 788] 15th Conference on Retroviruses and Opportunistic Infections Boston 2008
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15th Conference on Retroviruses and Opportunistic Infections. Boston, 2008
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Cooper, D.1
Gatell, J.2
Rockstroh, J.3
Katlama, C.4
Yeni, P.5
Lazzarin, A.6
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8
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43749084994
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48-Week Results from BENCHMRK-2, a Phase III Study of Raltegravir in Patients Failing Antiretroviral Therapy (ART) with Triple-Class Resistant HIV-1
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for the BENCHMRK-2 Study Group [Abstract 789]
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R. Steigbigel, P. Kumar, J. Eron, M. Schechter, M. Markowitz, M. Loutfy, et al. for the BENCHMRK-2 Study Group 48-Week Results from BENCHMRK-2, a Phase III Study of Raltegravir in Patients Failing Antiretroviral Therapy (ART) with Triple-Class Resistant HIV-1 [Abstract 789] 15th Conference on Retroviruses and Opportunistic Infections Boston 2008
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15th Conference on Retroviruses and Opportunistic Infections. Boston, 2008
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Steigbigel, R.1
Kumar, P.2
Eron, J.3
Schechter, M.4
Markowitz, M.5
Loutfy, M.6
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9
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42049119625
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Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
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I. Malet, O. Delelis, M. Valantin, B. Montes, C. Soulie, M. Wirden, et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro Antimicrob Agents Chemother 52 2008 1351 1358
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Malet, I.1
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Valantin, M.3
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Soulie, C.5
Wirden, M.6
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10
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54049102468
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Drug resistance profiles of HIV integrase gene in patients failing Raltegravir-salvage therapy
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Abstract 48
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C. Charpentier, M. Karmochkine, D. Laureillard, P. Tisserand, L. Bélec, L. Weiss, et al. Drug resistance profiles of HIV integrase gene in patients failing Raltegravir-salvage therapy [Abstract 48] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Charpentier, C.1
Karmochkine, M.2
Laureillard, D.3
Tisserand, P.4
Bélec, L.5
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11
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75149167447
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Raltegravir clinical response and resistance in heavily experienced patients
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C. Garrido, F. Blanco, K. Van Baelen, N. Zahonero, J. González-Lahoz, J. Villacian, et al. Raltegravir clinical response and resistance in heavily experienced patients [Abstract 52] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Garrido, C.1
Blanco, F.2
Van Baelen, K.3
Zahonero, N.4
González-Lahoz, J.5
Villacian, J.6
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12
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75149147152
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Resistance and cross-resistance to first generation integrase inhibitors: Insights form a Phase 2 study of Elvitegravir (GS-9137)
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Abstract 9
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D. Mc Coll, S. Fransen, S. Gupta, N. Parkin, N. Margot, R. Ledford, et al. Resistance and cross-resistance to first generation integrase inhibitors: Insights form a Phase 2 study of Elvitegravir (GS-9137) [Abstract 9] 16th International HIV Drug Resistance Workshop Barbados, 12-16 June 2007
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16th International HIV Drug Resistance Workshop. Barbados, 12-16 June 2007
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Mc Coll, D.1
Fransen, S.2
Gupta, S.3
Parkin, N.4
Margot, N.5
Ledford, R.6
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13
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38849154086
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Raltegravir
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DOI 10.1038/nrd2512, PII NRD2512
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S. Deeks, S. Kar, S. Gubernick, and P. Kirkpatrick Raltegravir Nature Rev 7 2008 117 118 (Pubitemid 351194059)
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Deeks, S.G.1
Kar, S.2
Gubernick, S.I.3
Kirkpatrick, P.4
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14
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75149184050
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Preliminary biological cut-offs for GS-9137 and MK-0518 integrase inhibitors derived from clonal phenotypic analysis
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E. Rondelez, K. Van Baelen, F. Ceccherini-Silverstein, V. Van Eygen, P. Van den Zegel, B. Winters, et al. Preliminary biological cut-offs for GS-9137 and MK-0518 integrase inhibitors derived from clonal phenotypic analysis [Abstract 73] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Rondelez, E.1
Van Baelen, K.2
Ceccherini-Silverstein, F.3
Van Eygen, V.4
Van Den Zegel, P.5
Winters, B.6
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15
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35348891666
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Short communication: Dynamics of drug-resistant HIV-1 in plasma and peripheral blood cells in patients during and after enfuvirtide therapy
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DOI 10.1089/aid.2006.0287
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E. Poveda, V. Briz, D. Paraskevis, P. Barreiro, A. Hatzakis, and V. Soriano Dynamics of drug-resistant HIV-1 in plasma and peripheral blood cells in patients during and after enfuvirtide therapy AIDS Res Hum Retroviruses 23 2007 1078 1082 (Pubitemid 47571945)
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Poveda, E.1
Briz, V.2
Paraskevis, D.3
Barreiro, P.4
Hatzakis, A.5
Soriano, V.6
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16
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75149133234
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Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor GS- 9137 (JTK-303)
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Abstract 627
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G. Jones, R. Ledford, F. Yu, M. Miller, M. Tsiang, and D. McColl Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor GS- 9137 (JTK-303) [Abstract 627] 14th Conference on Retrovirus and Opportunistic Infections Los Angeles, 25-28 February 2007
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14th Conference on Retrovirus and Opportunistic Infections. Los Angeles, 25-28 February 2007
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Jones, G.1
Ledford, R.2
Yu, F.3
Miller, M.4
Tsiang, M.5
McColl, D.6
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17
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0034723439
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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
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DOI 10.1126/science.287.5453.646
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D. Hazuda, P. Felock, M. Witmer, A. Wolfe, K. Stillmock, and J. Grobler Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells Science 287 2000 646 650 (Pubitemid 30070911)
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Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
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18
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75149139865
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First report of raltegravir (RAL, MK-0518) use alter virologic rebound on elvitegravir (EVT, GS-9137)
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Abstract TUPEB032
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E. DeJesus, C. Cohen, R. Elion, R. Ortiz, L. Haroldo, S. Franson, et al. First report of raltegravir (RAL, MK-0518) use alter virologic rebound on elvitegravir (EVT, GS-9137) [Abstract TUPEB032] 4th IAS Conference on HIV Sydney 2007 22-25 July
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4th IAS Conference on HIV. 22-25 July 2007, Sydney
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Dejesus, E.1
Cohen, C.2
Elion, R.3
Ortiz, R.4
Haroldo, L.5
Franson, S.6
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19
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75149150786
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Next generation of inhibitors of HIV-1 integrase strand transfer inhibitor: Structural diversity and resistance profiles
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Abstract 87
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J. Wai, T. Fisher, M. Embrey, M. Egbertson, J. Vacca, D. Hazuda, et al. Next generation of inhibitors of HIV-1 integrase strand transfer inhibitor: Structural diversity and resistance profiles [Abstract 87] 14th Conference on Retrovirus and Opportunistic Infections Los Angeles, 25-28 February 2007
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14th Conference on Retrovirus and Opportunistic Infections. Los Angeles, 25-28 February 2007
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Wai, J.1
Fisher, T.2
Embrey, M.3
Egbertson, M.4
Vacca, J.5
Hazuda, D.6
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20
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34447263572
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Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
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M. Lataillade, J. Chiarella, and M. Kozal Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance Antivir Ther 12 2007 563 570 (Pubitemid 47041156)
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Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
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75149178627
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Polymorphisms at the integrase gene in distinct HIV populations may influence the susceptibility to integrase inhibitors
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Abstract 12
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C. Garrido, A.M. Geretti, C. De Mendoza, C. Booth, A. Strang, and V. Soriano Polymorphisms at the integrase gene in distinct HIV populations may influence the susceptibility to integrase inhibitors [Abstract 12] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Garrido, C.1
Geretti, A.M.2
De Mendoza, C.3
Booth, C.4
Strang, A.5
Soriano, V.6
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24
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66349088575
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Naturally occurring polymorphisms in HIV-1 group M, N, and O integrase: Implications for integrase inhibitors
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Abstract 872
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J. Hackett, B. Harris, V. Holzmayer, J. Yamaguchi, C. Luk K, C. Brennan, et al. Naturally occurring polymorphisms in HIV-1 group M, N, and O integrase: implications for integrase inhibitors [Abstract 872] 15th Conference on Retroviruses and Opportunistic Infections Boston 2008
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15th Conference on Retroviruses and Opportunistic Infections. Boston, 2008
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Hackett, J.1
Harris, B.2
Holzmayer, V.3
Yamaguchi, J.4
Luk, K.C.5
Brennan, C.6
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25
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75149125603
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Analysis of integrase inhibitor (INI) resistance of HIV-1 group M in ARTnaïve and -experienced but INI-naïve patients in Germany
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Abstract 67
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N. Sichtig, M. Däumer, S. Esser, U. Dittmer, E. Schülter, M. Oette, et al. Analysis of integrase inhibitor (INI) resistance of HIV-1 group M in ARTnaïve and -experienced but INI-naïve patients in Germany [Abstract 67] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March
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Sichtig, N.1
Däumer, M.2
Esser, S.3
Dittmer, U.4
Schülter, E.5
Oette, M.6
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26
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48749125405
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Polymorphism of HIV-2 integrase gene and in vitro phenotypic susceptibility of HIV-2 clinical isolates to integrase inhibitors: Raltegravir and elvitegravir
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The French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2) [Abstract 83]
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B. Roquebert, F. Damond, G. Collin, S. Matheron, A. Taieb, G. Peytavin, et al, The French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2) Polymorphism of HIV-2 integrase gene and in vitro phenotypic susceptibility of HIV-2 clinical isolates to integrase inhibitors: raltegravir and elvitegravir [Abstract 83] Antivir Ther 12 2007 S92
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Roquebert, B.1
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Collin, G.3
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Taieb, A.5
Peytavin, G.6
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27
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75149172307
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Etravirine and Raltegravir are active against HIV-1 group O
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Abstract 71
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V. Briz, C. Garrido, J. Morello, C. De Mendoza, and V. Soriano Etravirine and Raltegravir are active against HIV-1 group O [Abstract 71] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Briz, V.1
Garrido, C.2
Morello, J.3
De Mendoza, C.4
Soriano, V.5
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28
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43049095987
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HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: A view from the clinic and ex vivo
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en prensa
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Martínez-Picado J, Martínez MA. HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: A view from the clinic and ex vivo. Virus Res. 2008 [en prensa].
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75149145009
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Evolution of HIV-1 pol under HAART does not restrict fitness progression of HIV-1 integrase
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Abstract 49
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M. Buzón, S. Marfil, M. Puertas, E. García, B. Clotet, J. Blanco, et al. Evolution of HIV-1 pol under HAART does not restrict fitness progression of HIV-1 integrase [Abstract 49] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Buzón, M.1
Marfil, S.2
Puertas, M.3
García, E.4
Clotet, B.5
Blanco, J.6
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30
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34147136222
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Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
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DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
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B. Grinsztejn, B. Nguyen, C. Katlama, J.M. Gatell, A. Lazzarin, and D. Vittecoq Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial Lancet 369 2007 1261 1269 (Pubitemid 46553846)
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Grinsztejn, B.1
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Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
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31
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75149130016
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More pronounced effect of integrase inhibitor raltegravir on proviral DNA reduction that other antiretroviral drugs in patients achieving undetectable viremia
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Abstract 796
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S. Arponen, J. Benito, S. Lozano, F. Blanco, C. Garrido, C. De Mendoza, et al. More pronounced effect of integrase inhibitor raltegravir on proviral DNA reduction that other antiretroviral drugs in patients achieving undetectable viremia [Abstract 796] 15th Conference on Retroviruses and Opportunistic Infections Boston 2008
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15th Conference on Retroviruses and Opportunistic Infections. Boston, 2008
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Arponen, S.1
Benito, J.2
Lozano, S.3
Blanco, F.4
Garrido, C.5
De Mendoza, C.6
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32
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37849002059
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Broad antiretroviral activity and resistance profile of the novel HIV integrase inhibitor elvitegravir (JTK-303/GS-9137)
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K. Shimura, E. Kodama, Y. Sakagami, Y. Matsuzaki, W. Watanabe, K. Yamataka, et al. Broad antiretroviral activity and resistance profile of the novel HIV integrase inhibitor elvitegravir (JTK-303/GS-9137) J Virol 82 2008 764 774
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Shimura, K.1
Kodama, E.2
Sakagami, Y.3
Matsuzaki, Y.4
Watanabe, W.5
Yamataka, K.6
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33
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75149124366
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A genotypic assay for the amplification and sequencing of integrase from diverse HIV type 1 group M subtypes
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Abstract 78
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K. Van Laethem, Y. Schrooten, K. Covens, N. Dekeersmaeker, P. De Munter, E. Van Wijngaerden, et al. A genotypic assay for the amplification and sequencing of integrase from diverse HIV type 1 group M subtypes [Abstract 78] 6th European HIV Drug Resistance Workshop Budapest, 26-28 March 2008
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6th European HIV Drug Resistance Workshop. Budapest, 26-28 March 2008
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Van Laethem, K.1
Schrooten, Y.2
Covens, K.3
Dekeersmaeker, N.4
De Munter, P.5
Van Wijngaerden, E.6
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34
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52749092564
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Performance of prototype integrase genotyping reagents for analysis of diverse HIV-1 strains
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Abstract 881
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P. Smith, V. Holzmayer, L. Fang, P. Swanson, J. Hackett, and N. Marlowe Performance of prototype integrase genotyping reagents for analysis of diverse HIV-1 strains [Abstract 881] 15th Conference on Retroviruses and Opportunistic Infections Boston 2008
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15th Conference on Retroviruses and Opportunistic Infections. Boston, 2008
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Smith, P.1
Holzmayer, V.2
Fang, L.3
Swanson, P.4
Hackett, J.5
Marlowe, N.6
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