Higher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection

Clinical Transplantation

Volumn 23, Issue 4, 2009, Pages 462-468

  O'Seaghdha, C M ^a   McQuillan, R ^a   Moran, A M ^a   Lavin, P ^a   Dorman, A ^a   O'Kelly, P ^a   Mohan, D M ^a   Little, P ^a   Hickey, D P ^a   Conlon, Peter J ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Acute rejection; Kidney transplant; Tacrolimus

Indexed keywords

CREATINE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; COLD ISCHEMIA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DELAYED GRAFT FUNCTION; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; FEMALE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CADAVER; CHILD; CHILD, PRESCHOOL; DRUG MONITORING; DRUG THERAPY, COMBINATION; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; PREDNISOLONE; RETROSPECTIVE STUDIES; TACROLIMUS; YOUNG ADULT;

EID: 68349139533     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01021.x     Document Type: Article

References (23)

1. Danovitch GM, Cohen DJ, Weir MR et al. Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant 2005: 5: 904.
2. Sayegh MH, Turka LA. The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 1998: 338: 1813.
3. Kreisel D, Krupnick AS, Gelman AE et al. Non-hematopoietic allograft cells directly activate CD8+T cells and trigger acute rejection: An alternative mechanism of allorecognition. Nat Med 2002: 8: 233.
4. Denton MD, Magee CC, Sayegh MH. Immunosuppressive strategies in transplantation. Lancet 1999: 353: 1083.
5. Gotti E, Perico N, Gaspari F et al. Blood cyclosporine level soon after kidney transplantation is a major determinant of rejection: Insights from the Mycophenolate Steroid-Sparing Trial. Transplant Proc 2005: 37: 2037.
6. Perico N, Ruggenenti P, Gotti E et al. In renal transplantation blood cyclosporine levels soon after surgery act as a major determinant of rejection: Insights from the MY.S.S. trial. Kidney Int 2004: 65: 1084.
7. El-Sabrout R, Delaney V, Butt F et al. Improved freedom from rejection after a loading dose of sirolimus. Transplantation 2003: 75: 86.
8. Staatz C, Taylor P, Tett S. Low tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation. Nephrol Dial Transplant 2001: 16: 1905.
9. Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993: 44: 411.
10. Basadonna GP, Matas AJ, Gillingham KJ et al. Early versus late acute renal allograft rejection: Impact on chronic rejection. Transplantation 1993: 55: 993.
11. Koning OH, Ploeg RJ, van Bockel JH et al. Risk factors for delayed graft function in cadaveric kidney transplantation: A prospective study of renal function and graft survival after preservation with University of Wisconsin solution in multi-organ donors. European Multicenter Study Group. Transplantation 1997: 63: 1620.
12. Gourishankar S, Jhangri GS, Tonelli M, Wales LH, Cockfield SM. Development of diabetes mellitus following kidney transplantation: A Canadian experience. Am J Transplant 2004: 4: 1876.
13. Romagnoli J, Citterio F, Violi P, Cadeddu F, Nanni G, Castagneto M. Post-transplant diabetes mellitus: A case-control analysis of the risk factors. Transpl Int 2005: 18: 309.
14. Rodrigo E, Pinera C, de Cos MA, Sanchez B et al. Evolution of tacrolimus blood levels and concentration-dose ratios in patients who develop new onset diabetes mellitus after kidney transplantation. Transpl Int 2005: 18: 1152.
15. Pretransplant assessment of tacrolimus blood level concentration, as a predictor of tacrolimus dose requirements after kidney transplantation. In press. ClinicalTrials.gov ID NCT00297310.
16. Friedman AL, Goker O, Kalish MA et al. Renal transplant recipients over aged 60 have diminished immune activity and a low risk of rejection. Int Urol Nephrol 2004: 36: 451.
17. Palomar R, Ruiz JC, Zubimendi JA et al. Acute rejection in the elderly recipient: Influence of age in the outcome of kidney transplantation. Int Urol Nephrol 2002: 33: 145.
18. Palomar R, Ruiz JC, Cotorruelo JG et al. Effect of recipient age on the clinical course of renal transplantation. Nefrologia 2001: 21: 386.
19. Naumovic R, Djukanovic L, Marinkovic J, Lezaic V. Effect of donor age on the outcome of living-related kidney transplantation. Transpl Int 2005: 18: 1266.
20. de Fijter JW, Mallat MJ, Doxiadis II et al. Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 2001: 12: 1538.
21. Kim JS, Aviles DH, Silverstein DM Leblanc PL, Matti Vehaskari V. Effect of age, ethnicity, and glucocorticoid use on tacrolimus pharmacokinetics in pediatric renal transplant patients. Pediatr Transplant 2005: 9: 162.
22. Przepiorka D, Blamble D, Hilsenbeck S, Danielson M, Krance R, Chan KW. Tacrolimus clearance is age-dependent within the pediatric population. Bone Marrow Transplant 2000: 26: 601.
23. Schwarz MP, Richards MH, Danforth BN. Changing paradigms in insect social evolution: Insights from halictine and allodapine bees. Annu Rev Entomol 2007: 52: 127.