Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 12874-12885

  Panchal, Rekha G ^a   Ulrich, Ricky L ^a   Bradfute, Steven B ^a   Lane, Douglas ^b   Ruthel, Gordon ^a   Kenny, Tara A ^b   Iversen, Patrick L ^c   Anderson, Arthur O ^a   Gussio, Rick ^d   Raschke, William C ^e,f   Bavari, Sina ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b SAIC FREDERICK INC   (United States)

^c AVI BIOPHARMA INC   (United States)

^d Developmental Therapeutics Program   (United States)

^e SIDNEY KIMMEL CANCER CENTER   (United States)

^f Virogenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACIS; ANTISENSE; APOPTOSIS; BACILLUS ANTHRACIS; CELLULAR PATHWAY; CELLULAR PROCESS; GENE INACTIVATION; GENETIC SCREENING; IMMUNE CELLS; IN-VIVO; INTERMEDIATE LEVEL; PHOSPHATASE ACTIVITY; PHOSPHATASE INHIBITORS; POTENT COMPOUNDS; PROTEIN-TYROSINE PHOSPHATASE; SMALL MOLECULE INHIBITOR;

AMINO ACIDS; BACTERIOLOGY; CHEMICAL COMPOUNDS; MACROPHAGES; OLIGOMERS;

CELL DEATH;

4 NITROPHENANTHRENE 9,10 DIONE; CD45 ANTIGEN; CD45 ANTIGEN INHIBITOR; CD45 ANTISENSE PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER; N (9,10 DIOXO 9,10 DIHYDROPHENANTHREN 2 YL) 2,2 DIMETHYLPROPIONAMIDE; NSC 270012; NSC 95397; PHENANTHRENE 9,10 DIONE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; APOPTOSIS; ARTICLE; BACILLUS ANTHRACIS; BAGG ALBINO MOUSE; CELL DEATH; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; GENETIC SCREENING; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; ANTIGENS, CD45; APOPTOSIS; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL SURVIVAL; FEMALE; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; GENETIC SCREENING; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHOLINES; PHAGOCYTOSIS; PHOSPHORIC MONOESTER HYDROLASES; SPORES, BACTERIAL;

BACILLUS ANTHRACIS; MUS;

EID: 67649690985     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809633200     Document Type: Article

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