Lipofuscin and autofluorescence metrics in progressive STGD

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 8, 2009, Pages 3907-3914

  Smith, R Theodore ^a   Gomes, Nuno L ^a   Barile, Gaetano ^a   Busuioc, Mihai ^a   Lee, Noah ^b   Laine, Andrew ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOFUSCIN; ABC TRANSPORTER; ABCA4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; AUTOANALYSIS; AUTOFLUORESCENCE IMAGING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; MALE; PHASE TRANSITION; PRIORITY JOURNAL; RETINA MACULA LUTEA; STARGARDT DISEASE; DISEASE COURSE; FLUORESCENCE; GENETICS; GENOTYPE; METABOLISM; MIDDLE AGED; OPHTHALMOSCOPY; OPTIC NERVE ATROPHY; PATHOPHYSIOLOGY; PIGMENT EPITHELIUM; PREDICTION AND FORECASTING; RETINA MACULA DEGENERATION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; ATP-BINDING CASSETTE TRANSPORTERS; CHILD; DISEASE PROGRESSION; FEMALE; FLUORESCENCE; GENOTYPE; HUMANS; LIPOFUSCIN; MACULAR DEGENERATION; MALE; MIDDLE AGED; OPHTHALMOSCOPY; OPTIC ATROPHY; PREDICTIVE VALUE OF TESTS; RETINAL PIGMENT EPITHELIUM; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 68349114905     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2448     Document Type: Article

References (22)

1. Feeney-Burns L, Berman ER, Rothman H. Lipofuscin of human retinal pigment epithelium. Am J Ophthalmol. 1980;90(6):783-791.
2. Katz ML, Gao CL, Rice LM. Formation of lipofuscin-like fluoro-phores by reaction of retinal with photoreceptor outer segments and liposomes. Mech Ageing Dev. 1996;92(2-3):159-174.
3. Kennedy CJ, Rakoczy PE, Constable IJ. Lipofuscin of the retinal pigment epithelium: a review. Eye. 1995;9:763-771.
4. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986;27(2):145-152.
5. Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res. 2005;80(5):595-606.
6. Boulton M, McKechnie M, Breda J, Bayly M, Marshall J. The formation of autofluorescent granules in cultured human RPE. Invest Ophthalmol Vis Sci. 1989;30(1):82-89.
7. Young RW. Pathophysiology of age-related macular degeneration. Sur Ophthalmol. 1987;31(5):291-306.
8. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ. Cell loss in the aging retina: relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci. 1989;30(8):1691-1699.
9. Holz FG, Schuett F, Kopitz J, et al. Inhibition of lysosomal degra-dative functions in RPE cells by a retinoid component of lipofus-cin. Invest Ophthalmol Vis Sci. 1999;40(3):737-743.
10. Zhou J, Cai B, Jang YP, Pachydaki S, Schmidt AM, Sparrow JR. Mechanisms for the induction of HNE-MDA-and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. Exp Eye Res. 2005;80(4):567-580.
11. Sparrow JR, Fishkin N, Zhou J, et al. A2E, a byproduct of the visual cycle. Vision Res. 2003;43(28):2983-2990.
12. Frangieh GT, Green WR, Fine SL. A histopathologic study of Best's macular dystrophy. Arch Ophthalmol. 1982;100(7):1115-1121.
13. O'Gorman S, Flaherty WA, Fishman GA, Berson EL. Histopathologic findings in Best's vitelliform macular dystrophy. Arch Ophthalmol. 1988;106(9):1261-1268.
14. Delori FC, Fleckner MR, Goger DG, et al. Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2000;41(2):496-504.
15. Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36(3):718-729.
16. von Ruckmann A, Fitzke FW, Bird AC. Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci. 1997;38(2):478-486.
17. von Ruckmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope [comment]. Br J Ophthalmol. 1995;79(5):407-412.
18. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42(5):1051-1056.
19. Hwang JC, Chan JWK, Chang S, Smith RT. Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006;47(6):2655-2661.
20. Smith RT, Koniarek JP, Chan J, Nagasaki T, Sparrow JR, Langton K. Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthal-mol Vis Sci. 2006;47(12):5495-5504.
21. Lois N, Halfyard AS, Bird AC, Holder GE, Fitzke FW. Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimacu-latus. Am J Ophthalmol. 2004;138(1):55-63.
22. Smith RT, Nagasaki T, Sparrow JR, Barbazetto I, Klaver CCW, Chan JK. A method of drusen measurement based on the geometry of fundus reflectance. Biomedical Eng Online. 2003;2:10.