Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster

Journal of Insect Physiology

Volumn 55, Issue 10, 2009, Pages 927-935

  Chahine, Sarah ^a   O'Donnell, Michael J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Drosophila melanogaster; Insect renal epithelia; Malpighian tubule; Methotrexate; Organic anion transport

Indexed keywords

ABC TRANSPORTER; DROSOPHILA PROTEIN; METHOTREXATE;

FLY; GENE EXPRESSION; ION; MOLECULAR ANALYSIS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RADIONUCLIDE; TRACER;

ANIMAL; ARTICLE; CHEMISTRY; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENETICS; KINETICS; MALPIGHIAN TUBULE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION; KINETICS; MALPIGHIAN TUBULES; METHOTREXATE;

DROSOPHILA MELANOGASTER; HEXAPODA;

EID: 68349112597     PISSN: 00221910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinsphys.2009.06.005     Document Type: Article

References (39)

1. Abe T., Koike K., Ohga T., Kubo T., Wada M., Kohno K., Mori T., Hidaka K., and Kuwano M. Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1. British Journal of Cancer 72 2 (1995) 418-423
2. Affleck J.G., Neumann K., Wong L., and Walker V.K. The effects of methotrexate on Drosophila development, female fecundity, and gene expression. Toxicolological Science 89 (2006) 495-503
3. Blumenthal E.M. Regulation of chloride permeability by endogenously produced tyramine in the Drosophila Malpighian tubule. American Journal of Physiology (Cell Physiology) 284 (2003) C718-C728
4. Bresler V.M., Belyaeva E.A., and Mozhayeva M.G. A comparative study on the system of active transport of organic acids in Malpighian tubules of insects. Journal of Insect Physiology 36 (1990) 259-270
5. Chintapalli V.R., Wang J., and Dow J.A.T. Using FlyAtlas to identify better Drosophila models of human disease. Nature Genetics 39 (2007) 715-720
6. Dow J.A.T., Maddrell S.H.P., Gortz A., Skaer N.J.V., Brogan S., and Kaiser K. The Malpighian tubules of Drosophila melanogaster: a novel phenotype for studies of fluid secretion and its control. Journal of Experimental Biology 197 (1994) 421-428
7. Dube K., McDonald D.G., and O'Donnell M.J. Calcium transport by isolated anterior and posterior Malpighian tubules of Drosophila melanogaster: roles of sequestration and secretion. Journal of Insect Physiology 46 (2000) 1449-1460
8. El-Sheikh A.K., van den Heuvel J.M.W., Koenderink B., and Russel G.M. Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. Journal of Pharmacology and Experimental Therapeutics 320 (2007) 229-235
9. + channels in Drosophila melanogaster renal function. Journal of Experimental Biology 208 (2005) 3771-3783
10. Gifford A.J., Kavallaris M., Madafiglio J., Matherly L.H., Stewart B.W., Haber M., and Norris M.D. P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene. International Journal of Cancer 78 (1998) 176-181
11. Hooijberg J.H., Broxterman H.J., Kool M., Assaraf Y.G., Peters G.J., Noordhuis P., Scheper R.J., Borst P., Pinedo H.M., and Jansen G. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Research. 59 (1999) 2532-2535
12. Karnaky K.J., Hazen-Martin D., and Miller D.S. The xenobiotic transporter, MRP2, in epithelia from insects, sharks, and the human breast: Implications for health and disease. Journal of Experimental Zoology 300A (2003) 91-97
13. Krupka R.M. The kinetics of transport inhibition by noncompetitive inhibitors. Journal of Membrane Biology 74 (1983) 175-182
14. Leader J.P., and O'Donnell M.J. Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: Confocal microscopic analysis of secreted fluid droplets. Journal of Experimental Biology 208 (2005) 4363-4376
15. Lee W., and Kim R.B. Transporters and renal drug elimination. Annual Review of Pharmacology and Toxicology 44 (2004) 137-166
16. Li X., Schuler M.A., and Berembaum M.R. Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes. Nature 419 (2002) 712-715
17. Li X., Schuler M.A., and Berenbaum M.R. Molecular mechanism of metabolic resistance to synthetic and natural xenobiotics. Annual Review of Entomology 52 (2007) 231-253
18. Linton S.M., and O'Donnell M.J. Novel aspects of the transport of organic anions by the Malpighian tubules of Drosophila melanogaster. Journal of Experimental Biology 203 (2000) 3575-3584
19. Lison L. Etudes histophysiologiques sur les tubes de Malpighi des Insectes. I. Elimination des colorants acides chez les Orthopteres. Archives de Biologie Paris 48 (1937) 321-360
20. MacPherson M.R., Pollock V.P., Broderick K.E., Kean L., O'Connell F.C., Dow J.A., and Davies S.A. Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology 280 (2001) C394-C407
21. Maddrell S.H.P., Gardiner O.C., Pilcher D.E.M., and Reynolds S.E. Active transport by insect Malpighian tubules of acidic dyes and of acylamides. Journal of Experimental Biology 61 (1974) 357-377
22. 2 and external buffering on ammonia excretion and Rhesus glycoprotein mRNA expression in rainbow trout. Journal of Experimental Biology 211 20 (2008) 3226-3236
23. Neufeld D.S.G., Kauffman R., and Kurtz Z. Specificity of the fluorescein transport process in Malpighian tubules of the cricket Acheta domesticus. Journal of Experimental Biology 208 (2005) 2227-2236
24. Nozaki Y., Kusuhara H., Endou H., and Sugiyama Y. Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier. Journal of Pharmacology and Experimental Therapeutics 309 1 (2004) 226-234
25. O'Donnell M.J., Dow J.A.T., and Huesmann G.R. Separate control of anion and cation transport in Malpighian tubules of Drosophila melanogaster. Journal of Experimental Biology 199 (1996) 1163-1175
26. O'Donnell M.J., Ianowski J.P., Linton S.M., and Rheault M.R. Inorganic and organic anion transport by insect renal epithelia. Biochimica et Biophysica Acta 1618 (2003) 194-206
27. O'Donnell M.J., and Leader J.P. Changes in fluid secretion rate alter net transepithelial transport of MRP2 and p-glycoprotein substrates in Malpighian tubules of Drosophila melanogaster. Archives of Insect Biochemistry and Physiology 63 (2006) 123-134
28. O'Donnell M.J., and Rheault M.R. Ion-selective microelectrode analysis of salicylate transport by the Malpighian tubules and gut of Drosophila melanogaster. Journal of Experimental Biology 208 (2005) 93-104
29. Palm N.B. Storage and excretion of vital dyes in insects. Arkiv för Zoologi 3 (1952) 195-272
30. Roberts D.B., and Stander G.N. Drosophila: A Practical Approach (1998), Oxford University Press, UK
31. Ruiz-Sanchez E., and O'Donnell M.J. Characterization of transepithelial transport of salicylate by the Malpighian tubules of D. melanogaster and the effects of changes in fluid secretion rate. Physiological Entomology 32 (2007) 157-166
32. Ruiz-Sanchez E., and O'Donnell M.J. Effects of chronic exposure to dietary salicylate on elimination and renal excretion of salicylate by Drosophila melanogaster larvae. Journal of Experimental Biology 210 (2007) 2464-2471
33. Russel F.G.M., Masereeuw R., and van Aubel R.A. Molecular aspects of renal anionic drug transport. Annual Review of Physiology 64 (2002) 563-594
34. Tapadia M.G., and Lakhotia S.C. Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions. Cell Stress Chaperones 10 (2005) 7-11
35. Tarnay J.N., Szeri F., Ilias A., Annilo T., Sung C., Le Saux O., Varadi A., Dean M., Boyd C.D., and Robinow S. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Insect Molecular Biology 13 (2004) 539-548
36. Torrie L.S., Radford J.C., Southall T.D., Kean L., Dinsmore A.J., Davies S.A., and Dow J.A.T. Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences 101 (2004) 13689-13693
37. Wang J., Kean L., Yang J., Allan A.K., Davies S.A., Herzyk P., and Dow J.A. Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology 5 9 (2004) R69
38. Winkler H., and Powell S. Applications of RNA interference. Targets 2 (2003) 42-44
39. Zeng H., Bain L.J., Belinsky M.G., and Kruh G.D. Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents. Cancer Research 59 (1999) 5964-5967