Properties of PASP: A pseudomonas protease capable of mediating corneal erosions

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 8, 2009, Pages 3794-3801

  Tang, Aihua ^a   Marquart, Mary E ^a   Fratkin, Jonathan D ^b   McCormick, Clare C ^a   Caballero, Armando R ^a   Gatlin, Hattie P ^b   O'Callaghan, Richard J ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; COLLAGEN TYPE 1; COLLAGEN TYPE 4; PSEUDOMONAS AERUGINOSA SMALL PROTEINASE; UNCLASSIFIED DRUG; COLLAGEN; PSEUDOMONAS SERINE PROTEINASE; RECOMBINANT PROTEIN; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA EROSION; CORNEA STROMA; CYTOPLASM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; ENZYME SYNTHESIS; GENE INACTIVATION; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOGENICITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; PSEUDOMONAS AERUGINOSA; RABBIT; SLIT LAMP; WESTERN BLOTTING; ANIMAL; BACTERIAL EYE INFECTION; CORNEA; CORNEA DISEASE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INJECTION; METABOLISM; MICROBIOLOGY; NEUTROPHIL; PHYSIOLOGY; PSEUDOMONAS INFECTION;

ANIMALS; BLOTTING, WESTERN; CHEMOTAXIS, LEUKOCYTE; COLLAGEN; CORNEA; CORNEAL DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE INFECTIONS, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; INJECTIONS; NEUTROPHILS; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RABBITS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES;

EID: 68349104992     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3107     Document Type: Article

References (42)

1. Ohmagari N, Hanna H, Graviss L, et al. Risk factors for infections with multidrug-resistant Pseudomonas aeruginosa in patients with cancer. Cancer. 2005;104(1):205-212.
2. Govan JR, Brown AR, Jones AM. Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2007;2:153-164.
3. Armour AD, Shankowsky HA, Swanson T, Lee J, Tredget EE. The mpact of nosocomially-acquired resistant Pseudomonas aeruginosa infection in a burn unit. J Trauma. 2007;63(1):164-171.
4. Stover CK, Pham XQ, Erwin AL, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000;406:959-964.
5. Watt KG, Swarbrick HA. Trends in microbial keratitis associated with orthokeratology. Eye Contact Lens. 2007;33:373-377,382.
6. Huang SC, Wu SC, Wu WC, Hong HL. Microbial keratitis: a late complication of penetrating keratoplasty. Trans R Soc Trop Med Hyg. 2000;94:315-317.
7. Mah-Sadorra JH, Yavuz SG, Najjar DM, Laibson PR, Rapuano CJ, Cohen EJ. Trends in contact lens-related corneal ulcers. Cornea. 2005;24(1):51-58.
8. Robertson DM, Petroll WM, Jester JV, Cavanagh HD. The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview. Eye Contact Lens. 2007;33:394-398,399-400.
9. Twining SS, Krishner SE, Mahnke LA, Frank DA. Effect of Pseudomonas aeruginosa elastase, alkaline protease, and exotoxin A on corneal proteinases and proteins. Invest Ophthalmol Vis Sci. 1993; 34:2699-2712.
10. Morihara K, Tsuzuki H, Oka T, Inoue H, Ebata M. Pseudomonas aeruginosa elastase: isolation, crystallization, and preliminary characterization. J Biol Chem. 1965;240:3295-3304.
11. Baumann U, Wu S, Flaherty KM, McKay DB. Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif. EMBO J. 1993;12:3357-3364.
12. Peters JE, Galloway DR. Purification and characterization of an active fragment of the LasA protein from Pseudomonas aeruginosa: enhancement of elastase activity. J Bacteriol. 1990; 172:2236-2240.
13. Engel LS, Hill JM, Caballero AR, Green LC, O'Callaghan RJ. Protease IV, a unique extracellular protease and virulence factor from Pseudomonas aeruginosa. J Biol Chem. 1998;273:16792-16797.
14. Okamoto T, Akaike T, Suga M, et al. Activation of human matrix metalloproteinases by various bacterial proteinases. J Biol Chem. 1997;272:6059-6066.
15. Alcorn JF, Wright JR. Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function. J Biol Chem. 2004;279(29):30871-30879.
16. Mariencheck WI, Alcorn JF, Palmer SM, Wright JR. Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. Am J Respir Cell Mol Biol. 2003;28(4):528-537.
17. Hong YQ, Ghebrehiwet B. Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3. Clin Immunol. 1992;62:133-138.
18. Caballero A, Thibodeaux B, Marquart M, Traidej M, O'Callaghan R. Pseudomonas keratitis: protease IV gene conservation, distribution, and production relative to virulence and other Pseudomonas proteases. Invest Ophthalmol Vis Sci. 2004;45:522-530.
19. Howe TR, Iglewski BH. Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model. Infect Immun. 1984;43(3):1058-1063.
20. Hobden JA. Pseudomonas aeruginosa proteases and corneal virulence. DNA Cell Biol. 2002;21(5-6):391-396.
21. Engel LS, Hobden JA, Moreau JM, Callegan MC, Hill JM, O'Callaghan RJ. Pseudomonas deficient in protease IV has significantly reduced corneal virulence. Invest Ophthalmol Vis Sci. 1997;38(8):1535-1542.
22. Steuhl KP, Doring G, Henni A, Thiel HJ, Botzenhart K. Relevance of host-derived and bacterial factors in Pseudomonas aeruginosa corneal infections. Invest Ophthalmol Vis Sci. 1987;28(9):1559-1568.
23. Thibodeaux BA, Caballero AR, Dajcs JJ, Marquart ME, Engel LS, O'Callaghan RJ. Pseudomonas aeruginosa protease IV: a corneal virulence factor of low immunogenicity. Ocul Immunol Inflamm. 2005;13(2-3):169-182.
24. Marquart ME, Caballero AR, Chomnawang M, Thibodeaux BA, Twining SS, O'Callaghan RJ. Identification of a novel secreted protease from Pseudomonas aeruginosa that causes corneal erosions. Invest Ophthalmol Vis Sci. 2005;46:3761-3768.
25. Caballero AR, Moreau JM, Engel LS, Marquart ME, Hill JM, O'Callaghan RJ. Pseudomonas aeruginosa protease IV enzyme assays and comparison to other Pseudomonas proteases. Anal Biochem. 2001;290(2):330-337.
26. O'Callaghan RJ, Engel LS, Hobden JA, Callegan MC, Green LC, Hill JM. Pseudomonas keratitis: the role of an uncharacterized xoprotein, protease IV, in corneal virulence. Invest Ophthalmol Vis Sci. 1996;37:534-543.
27. Hobden JA, Engel LS, Callegan MC, Hill JM, Gebhardt BM, O'Callaghan RJ. Pseudomonas aeruginosa keratitis in leukopenic rabbits. Curr Eye Res. 1993;12(5):461-467.
28. Dajcs JJ, Austin MS, Sloop GD, et al. Corneal pathogenesis of Staphylococcus aureus strain Newman. Invest Ophthalmol Vis Sci. 2002;43(4):1109-1115.
29. Moreau JM, Sloop GD, Engel LS, Hill JM, O'Callaghan RJ. Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas. Curr Eye Res. 1997;16(12):1221-1228.
30. Nakayasu K, Tanaka M, Konomi H, Hayashi T. Distribution of types I, II, III, IV and V collagen in normal and keratoconus corneas. Ophthalmic Res. 1986;18(1):1-10.
31. Lomholt JA, Poulsen K, Kilian M. Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors. Infect Immun. 2001;69(10):6284-6295.
32. Smith RS, Iglewski BHP. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol. 2003;6(1):56-60.
33. Fleiszig SM, Wiener-Kronish JP, Miyazaki H, et al. Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S. Infect Immun. 1997;65(2):579-86.
34. Heck LW, Morihara K, McRae WB, Miller EJ. Specific cleavage of human type III and IV collagens by Pseudomonas aeruginosa elastase. Infect Immun. 1986;51(1):115-118.
35. Kida Y, Higashimoto Y, Inoue H, Shimizu T, Kuwano K. A novel secreted protease from Pseudomonas aeruginosa activates NFkappaB through protease-activated receptors. Cell Microbiol. 2008;10(7):1491-1504.
36. Pinna A, Usai D, Sechi LA, Molicotti P, Zanetti S, Carta A. Detection of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens-associated corneal ulcers. Cornea. 2008;27(3): 320-326.
37. Kernacki KA, Hobden JA, Hazlett LD, Fridman R, Berk RS. In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci. 1995;36(7):1371-1378.
38. White CD, Alionte LG, Cannon BM, Caballero AR, O'Callaghan RJ, Hobden JA. Corneal virulence of LasA protease- deficient Pseudomonas aeruginosa PAO1. Cornea. 2001;20(6):643-646.
39. Alionte LG, Cannon BM, White CD, Caballero AR, O'Callaghan RJ, Hobden JA. Pseudomonas aeruginosa LasA protease and corneal infections. Curr Eye Res. 2001;22(4):266-271.
40. Pillar CM, Hazlett LD, Hobden JA. Alkaline protease-deficient mutants of Pseudomonas aeruginosa are virulent in the eye. Curr Eye Res. 2000;21(3):730-739.
41. Malloy JL, Veldhuizen RA, Thibodeaux BA, O'Callaghan RJ, Wright JR. Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions. Am J Physiol Lung Cell Mol Physiol. 2005;288(2):L409-L418.
42. Traidej M, Caballero AR, Marquart ME, Thibodeaux BA, O'Callaghan RJ. Molecular analysis of Pseudomonas aeruginosa protease IV expressed in Pseudomonas putida. Invest Ophthalmol Vis Sci. 2003;44(1):190-196.