RNA editing in human cancer: Review

APMIS

Volumn 117, Issue 8, 2009, Pages 551-557

  Škarda, Jozef ^a   Amariglio, Ninette ^b,c   Rechavi, Gideon ^b,c  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

ADAR; Cancer; RNA editing; Tumor progression

Indexed keywords

ADAR1 ENZYME; ADAR2 ENZYME; ADENOSINE; ADENOSINE DEAMINASE; APOLIPOPROTEIN B; APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; ARGININE; CHYLOMICRON; CYTOSINE; GLUTAMATE RECEPTOR; GLUTAMINE; INOSINE; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; URACIL; WT1 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ALTERNATIVE RNA SPLICING; ASTROCYTOMA; CANCER GRADING; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; GLIOBLASTOMA; HUMAN; INTESTINE CELL; NEOPLASM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEOMICS; REGULATORY RNA SEQUENCE; REVIEW; RNA EDITING; RNA STRUCTURE; STOP CODON; TRANSCRIPTOMICS; TUMOR GROWTH;

ADENOSINE DEAMINASE; APOLIPOPROTEIN B-100; APOLIPOPROTEIN B-48; HUMANS; NEOPLASMS; PROTEIN TYROSINE PHOSPHATASES; RECEPTORS, GLUTAMATE; RNA EDITING; RNA, MESSENGER;

EID: 68349091641     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2009.02505.x     Document Type: Review

References (48)

1. Kampa D, Cheng J, Kapranov P, Yamanaka M, Brubaker S, Cawley S, et al. Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res 2004 14 : 331 42.
2. Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 2003 302 : 2141 4.
3. Bass BL. RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 2002 71 : 817 46.
4. Gott JM, Emeson RB. Functions and mechanisms of RNA editing. Annu Rev Genet 2000 34 : 499 531.
5. Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Science 2005 309 : 1534 9.
6. Rebagliati MR, Melton DA. Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity. Cell 1987 48 : 599 605.
7. Bass BL, Weintraub H. A developmentally regulated activity that unwinds RNA duplexes. Cell 1987 48 : 607 13.
8. Keegan LP, Gallo A, O'Connell MA. The many roles of an RNA editor. Nat Rev 2001 2 : 869 78.
9. Paul MS, Bass BL. Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J 1998 17 : 1120 7.
10. Levanon EY, Eisenberg E, Yelin R, Nemzer S, Hallegger M, Shemesh R, et al. Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol 2004 22 : 1001 5.
11. Levanon K, Eisenberg E, Rechavi G, Levanon EY. Letter from the editor: Adenosine-to-inosine RNA editing in Alu repeats in the human genome. EMBO Rep 2005 6 : 831 5.
12. Morse DP, Bass BL. Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci USA 1999 96 : 6048 53.
13. Athanasiadis A, Rich A, Maas S. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol 2004 2 : 391.
14. Kim DD, Kim TT, Walsh T, Kobayashi Y, Matise TC, Buyske S, et al. Widespread RNA editing of embedded alu elements in the human transcriptome. Genome Res 2004 14 : 1719 25.
15. Eisenberg E, Nemzer S, Kinar Y, Sorek R, Rechavi G, Levanon EY. Is abundant A-to-I RNA editing primate-specific? Trends Genet 2005 21 : 77 81.
16. Higuchi M, Maas S, Single FN, Hartner J, Rozov A, Burnashev N, et al. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 2000 406 : 78 81.
17. Wang Q, Khillan J, Gadue P, Nishikura K. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science 2000 290 : 1765 8.
18. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, et al. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 1997 387 : 303 8.
19. Lai F, Chen CX, Lee VM, Nishikura K. Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons. J Neurochem 1997 69 : 43 52.
20. Cenci C, Barzotti R, Galeano F, Corbelli S, Rota R, Massimi L, et al. Downregulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. J Biol Chem 2008 283 : 7251 60.
21. Lehmann KA, Bass BL. Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities. Biochemistry 2000 39 : 12875 84.
22. Polson AG, Bass BL. Preferential selection of adenosines for modification by doublestranded RNA adenosine deaminase. EMBO J 1994 13 : 5701 11.
23. Wong SK, Sato S, Lazinski DW. Substrate recognition by ADAR1 and ADAR2. RNA 2001 7 : 846 58.
24. Laurencikiene J, Kallman AM, Fong N, Bentley DL, Ohman M. RNA editing and alternative splicing: the importance of co-transcriptional coordination. EMBO Rep 2006 7 : 303 7.
25. Gallo A, Keegan LP, Ring GM, O'Connell MA. An ADAR that edits transcripts encoding ion channel subunits functions as a dimer. EMBO J 2003 22 : 3421 30.
26. Poulsen H, Jorgensen R, Heding A, Nielsen FC, Bonven B, Egebjerg J. Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain. RNA 2006 12 : 1350 60.
27. Valente L, Nishikura K. RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions. J Biol Chem 2007 282 : 16054 61.
28. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through doublestranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol 2005 25 : 6956 63.
29. Maas S, Kawahara Y, Tamburro KM, Nishikura K. A-to-I RNA editing and human disease. RNA Biol 2006 3 : 1 9.
30. Paz N, Levanon EY, Amariglio N, Heimberger AB, Ram Z, Constantini S, et al. Altered adenosine-to-inosine RNA editing in human cancer. Genome Res 2007 17 : 1586 95.
31. Maas S, Patt S, Schrey M, Rich A. Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci USA 2001 98 : 14687 92.
32. Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada N, Hagimura N, Okado H, et al. Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 2002 8 : 971 8.
33. Beghini A, Ripamonti CB, Peterlongo P, Roversi G, Cairoli R, Morra E, et al. RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum Mol Genet 2000 9 : 2297 304.
34. 2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 2007 27 : 7987 8001.
35. Rickert CH, Paulus W. Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst 2001 17 : 503 11.
36. Cohen KJ, Broniscer A, Glod J. Pediatric glial tumors. Curr Treat Options Oncol 2001 2 : 529 36.
37. Riedmann EM, Schopoff S, Hartner JC, Jantsch MF. Specificity of ADAR-mediated RNA editing in newly identified targets. RNA 2008 14 : 1110 8.
38. Nishimoto Y, Yamashita T, Hideyama T, Tsuji S, Suzuki N, Kwak S. Determination of editors at the novel A-to-I editing positions. Neurosci Res 2008 61 : 201 6.
39. Levanon EY, Eisenberg E. Algorithmic approaches for identification of RNA editing sites. Brief Funct Genomic Proteomic 2006 5 : 43 5.
40. Luciano DJ, Mirsky H, Vendetti NJ, Maas S. RNA editing of a miRNA precursor. RNA 2004 10 : 1174 7.
41. Nishikura K. Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol 2006 7 : 919 31.
42. Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev 2001 14 : 778 809.
43. Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008 133 : 217 22.
44. Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell 2003 115 : 199 208.
45. Blow MJ, Grocock RJ, van Dongen S, Enright AJ, Dicks E, Futreal PA, et al. RNA editing of human microRNAs. Genome Biol 2006 7 : 27.
46. Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, et al. Identification of microRNAs of the herpesvirus family. Nat Methods 2005 2 : 269 76.
47. Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 2007 315 : 1137 40.
48. Kawahara Y, Zinshteyn B, Chendrimada TP, Shiekhattar R, Nishikura K. RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex. EMBO Rep 2007 8 : 763 9.