Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model

Lung

Volumn 187, Issue 4, 2009, Pages 233-239

  Mrabat, Hicham ^a   Beagle, John ^a   Hang, Zhao ^a   Garg, Hari G ^a   Hales, Charles A ^a   Quinn, Deborah A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

HA; HAS3; Phosphodiesterase inhibitor III; Sepsis; Ventilation

Indexed keywords

ENZYME; HYALURONIC ACID; HYALURONIC ACID SYNTHASE 3; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MILRINONE; PHOSPHODIESTERASE III INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE; CONTROLLED STUDY; ENZYME INHIBITION; HEART RATE; HISTOLOGY; LUNG INJURY; LUNG LAVAGE; LUNG VENTILATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY PERMEABILITY; CHEMOKINE CXCL2; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEMODYNAMICS; HYALURONIC ACID; LIPOPOLYSACCHARIDES; LUNG; MALE; MILRINONE; NEUTROPHIL INFILTRATION; PHOSPHODIESTERASE 3 INHIBITORS; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION, ARTIFICIAL; RNA, MESSENGER; SEPSIS;

EID: 68349085748     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408-009-9157-3     Document Type: Article

References (37)

1. PH Weigel VC Hascall M Tammi 1997 Hyaluronan synthases J Biol Chem 272 13997 14000
2. BJ Goentzel PH Weigel RA Steinberg 2006 Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells Biochem J 39 347 354
3. N Itano T Sawai M Yoshida P Lenas Y Yamada M Imagawa T Shinomura M Hamaguchi Y Yoshida Y Ohnuki S Miyauchi AP Spicer JA McDonald K Kimata 1999 Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties J Biol Chem 274 25085 25092
4. N Itano K Kimata 2002 Mammalian hyaluronan synthases IUBMB Life 54 195 199 10.1080/15216540214929 (Pubitemid 36008328)
5. CM McKee MB Penno M Cowman MD Burdick RM Strieter C Bao PW Noble 1996 Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44 J Clin Invest 98 2403 2413
6. PW Noble CM McKee M Cowman HS Shin 1996 Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages J Exp Med 183 2373 2378
7. TC Laurent UB Laurent JR Fraser 1996 Serum hyaluronan as a disease marker Ann Med 28 241 253
8. R Hällgren T Samuelsson TC Laurent J Modig 1989 Accumulation of hyaluronan (hyaluronic acid) in the lung in adult respiratory distress syndrome Ann Rev Respir Dis 139 682 687
9. KJ Bai AP Spicer MM Mascarenhas L Yu CD Ochoa HG Garg DA Quinn 2005 The role of hyaluronan synthase 3 in ventilator-induced lung injury Am J Respir Crit Care Med 172 92 98
10. DB Evans 1989 Overview of cardiovascular physiologic and pharmacologic aspects of selective phosphodiesterase peak III inhibitors Am J Cardiol 63 9A 11A
11. G Dent SR White H Tenor K Bodtke C Schudt AR Leff H Magnussen KF Rabe 1998 Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors Pulm Pharmacol Ther 11 1 47 56
12. N Ueki T Taguchi M Takahashi M Adachi T Ohkawa Y Amuro T Hada K Higashino 2000 Inhibition of hyaluronan synthesis by vesnarinone in cultured human myofibroblasts Biochim Biophys Acta 1495 160 167
13. RK Simons RV Maier EY Chi 1991 Pulmonary effects of continuous endotoxin infusion in the rat Circ Shock 33 233 243
14. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254
15. P Barton J Garcia A Kouatli L Kitchen A Zorka C Lindsay S Lawless B Giroir 1996 Hemodynamic effects of IV milrinone lactate in pediatric patients with septic shock. A prospective, double blinded, randomized, placebo-controlled, interventional study Chest 109 1302 1312
16. JE Irazuzta RK Pretzlaff ME Rowin 2001 Amrinone in pediatric refractory septic shock: An open-label pharmacodynamic study Pediatr Crit Care 2 24 28
17. N Rich N West P McMaster J Alexander 2003 Milrinone in meningococcal sepsis Pediatr Crit 4 394 395
18. K Fan Chung 2006 Phosphodiesterase inhibitors in airways disease Eur J Pharmacol 533 110 117
19. C Schudt S Winder S Forderkunz A Hatzelmann V Ullrich 1991 Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai Naunyn Schmiedebergs Arch Pharmacol 344 682 690
20. AP Spicer JY Tien 2004 Hyaluronan and morphogenesis Birth Defects Res C Embryo Today 72 89 108
21. D Jiang J Liang J Fan S Yu S Chen Y Luo GD Prestwich MM Mascarenhas HG Garg DA Quinn RJ Homer DR Goldstein R Bucala PJ Lee R Medzhitov PW Noble 2005 Regulation of lung injury and repair by Toll-like receptors and hyaluronan Nat Med 11 1173 1179
22. M Mohamadzadeh H DeGrendele H Arizpe P Estess M Siegelman 1998 Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion J Clin Invest 101 97 108
23. EA Turley PW Noble LY Bourguignon 2002 Signaling properties of hyaluronan receptors J Biol Chem 277 4589 4592
24. C Termeer F Benedix J Sleeman C Fieber U Voith T Ahrens K Miyake M Freudenberg C Galanos JC Simon 2002 Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4 J Exp Med 195 99 111
25. KA Fitzgerald AG Bowie BS Skeffington LA O'Neill 2000 Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF- kappa B by hyaluronic acid fragments in T-24 carcinoma cells J Immunol 164 2053 2063
26. LF Li B Ouyang G Choukroun R Matyal M Mascarenhas B Jafari JV Bonventre T Force DA Quinn 2003 Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappa-inducing kinases Am J Physiol Lung Cell Mol Physiol 285 L464 L465
27. MR Horton S Shapiro C Bao CJ Lowenstein PW Noble 1999 Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages J Immunol 162 4171 4176
28. K Mikawa H Akamatsu K Nishina M Shiga N Maekawa H Obara Y Niwa 2000 The effect of phosphodiesterase III inhibitors on human neutrophil function Crit Care Med 28 1001 1005
29. MD Eisner T Thompson LD Hudson JM Luce D Hayden D Schoenfeld MA Matthay 2001 Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome Am J Respir Crit Care Med 164 231 236
30. JG Muscedere JB Mullen K Gan AS Slutsky 1994 Tidal ventilation at low airway pressures can augment lung injury Am J Respir Crit Care Med 149 1327 1334
31. RP Dellinger JM Carlet H Masur H Gerlach T Calandra J Cohen J Gea-Banacloche D Keh JC Marshall MM Parker G Ramsay JL Zimmerman JL Vincent MM Levy 2004 Surviving sepsis campaign guidelines for management of severe sepsis and septic shock Crit Care Med 32 858 873 (Pubitemid 38344143)
32. TB Csoka GI Frost R Stern 1997 Hyaluronidase in tissue invasion Invasion Metastasis 17 297 311
33. G Mendoza AI Alvarez MM Pulido AJ Molina G Merino R Real P Fernandes JG Prieto 2007 Inhibitory effects of different antioxidants on hyaluronan depolymerization Carbohydr Res 342 96 102
34. NA Jones SV Boswell R Lever CP Page 2005 The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro Pulm Pharmacol Ther 18 93 101
35. RE Howell LP Jenkins DE Howell Howell 1995 Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs J Pharmacol Exp Ther 275 703 709
36. H Tanaka K Tajimi K Kobayashi 1999 Milrinone improves arterial oxygenation in dogs with acute lung injury induced by oleic acid J Cardiovasc Pharmacol 34 806 810
37. SM Wang HY Lei MC Huang JM Wu CT Chen JN Wang JR Wang CC Liu 2005 Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema Pediatr Pulmonol 39 219 223