메뉴 건너뛰기




Volumn 30, Issue 3, 2009, Pages 315-324

The safety profile of ciclesonide in the treatment of persistent asthma

Author keywords

Adverse events; Asthma; Ciclesonide; Growth; Hypothalamic pituitary adrenal axis; Inhaled corticosteroid; Oral candidiasis; Oropharyngeal adverse events; Safety; Systemic adverse events

Indexed keywords

BUDESONIDE; CICLESONIDE; DEXAMETHASONE; FLUTICASONE PROPIONATE; PLACEBO; ANTIALLERGIC AGENT; PREGNANE DERIVATIVE;

EID: 68249152619     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2009.30.3224     Document Type: Review
Times cited : (7)

References (76)
  • 1
    • 36048947170 scopus 로고    scopus 로고
    • United States, Available online at, last accessed December 2006
    • National Center for Health Statistics. Asthma Prevalence, Health Care Use and Mortality: United States, 2003-05. Available online at www.cdc.gov/nchs/ products/pubs/pubd/hestats/ashtma03-05/asthma03-05.htm; last accessed December 2006.
    • (2005) Asthma Prevalence, Health Care Use and Mortality
  • 2
    • 73449105584 scopus 로고    scopus 로고
    • National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Programme. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Available online at www.nhlbi.nih.gov/guidelines/asthma/ asthgdln.pdf. 2007; last accessed October 2007.
    • National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Programme. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Available online at www.nhlbi.nih.gov/guidelines/asthma/ asthgdln.pdf. 2007; last accessed October 2007.
  • 4
    • 23844459571 scopus 로고    scopus 로고
    • Impact of disease severity on quality of life in adults with asthma
    • Horak E, Sawyer SM, Roberts M, et al. Impact of disease severity on quality of life in adults with asthma. Wien Klin Wochenschr 117:462-467, 2005.
    • (2005) Wien Klin Wochenschr , vol.117 , pp. 462-467
    • Horak, E.1    Sawyer, S.M.2    Roberts, M.3
  • 5
    • 0031227837 scopus 로고    scopus 로고
    • The burden of pediatric asthma
    • Lenney W. The burden of pediatric asthma. Pediatr Pulmonol Suppl 15:13-16. 1997.
    • (1997) Pediatr Pulmonol , Issue.SUPPL. 15 , pp. 13-16
    • Lenney, W.1
  • 6
    • 0026028362 scopus 로고
    • The social impact of asthma
    • Nocon A, and Booth T. The social impact of asthma. Fam Pract 8:37-41, 1991.
    • (1991) Fam Pract , vol.8 , pp. 37-41
    • Nocon, A.1    Booth, T.2
  • 7
    • 3543134378 scopus 로고    scopus 로고
    • Worldwide severity and control of asthma in children and adults: The global asthma insights and reality surveys
    • Rabe KF, Adachi M, Lai CK, et al. Worldwide severity and control of asthma in children and adults: The global asthma insights and reality surveys. J Allergy Clin Immunol 114:40-47, 2004.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 40-47
    • Rabe, K.F.1    Adachi, M.2    Lai, C.K.3
  • 8
    • 0034998038 scopus 로고    scopus 로고
    • The work impact of asthma and rhinitis: Findings from a population-based survey
    • Blanc PD, Trupin L, Eisner M, et al. The work impact of asthma and rhinitis: Findings from a population-based survey. J Clin Epidemiol 54:610-618, 2001.
    • (2001) J Clin Epidemiol , vol.54 , pp. 610-618
    • Blanc, P.D.1    Trupin, L.2    Eisner, M.3
  • 9
    • 0026606394 scopus 로고
    • Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study
    • Jeffery PK, Godfrey RW, Adelroth E, et al. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis 145:890-899, 1992.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 890-899
    • Jeffery, P.K.1    Godfrey, R.W.2    Adelroth, E.3
  • 10
    • 0034601431 scopus 로고    scopus 로고
    • Low-dose inhaled corticosteroids and the prevention of death from asthma
    • Suissa S, Ernst P, Benayoun S, et al. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 343:332-336, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 332-336
    • Suissa, S.1    Ernst, P.2    Benayoun, S.3
  • 11
    • 0037158108 scopus 로고    scopus 로고
    • Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthma
    • Sin DD, and Man SF. Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch Intern Med 162:1591-1595, 2002.
    • (2002) Arch Intern Med , vol.162 , pp. 1591-1595
    • Sin, D.D.1    Man, S.F.2
  • 13
    • 0026590451 scopus 로고
    • Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma
    • Djukanovic R, Wilson JW, Britten KM, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 145:669-674, 1992.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 669-674
    • Djukanovic, R.1    Wilson, J.W.2    Britten, K.M.3
  • 14
    • 33745284283 scopus 로고    scopus 로고
    • Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma
    • Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy 61:518-526, 2006.
    • (2006) Allergy , vol.61 , pp. 518-526
    • Buhl, R.1
  • 15
    • 33745375299 scopus 로고    scopus 로고
    • Systemic side effects of inhaled corticosteroids in patients with asthma
    • Dahl R. Systemic side effects of inhaled corticosteroids in patients with asthma. Respir Med 100:1307-1317, 2006.
    • (2006) Respir Med , vol.100 , pp. 1307-1317
    • Dahl, R.1
  • 16
    • 34248571681 scopus 로고    scopus 로고
    • Unmet needs in asthma: Global Asthma Physician and Patient (GAPP) Survey: Global adult findings
    • Canonica GW, Baena-Cagnani CE, Blaiss MS, et al. Unmet needs in asthma: Global Asthma Physician and Patient (GAPP) Survey: Global adult findings. Allergy 62:668-674, 2007.
    • (2007) Allergy , vol.62 , pp. 668-674
    • Canonica, G.W.1    Baena-Cagnani, C.E.2    Blaiss, M.S.3
  • 17
    • 33947251723 scopus 로고    scopus 로고
    • Impact of inhaled corticosteroid-induced oropharyngeal adverse events: Results from a meta-analysis
    • Rachelefsky GS, Liao Y, and Faruqi R. Impact of inhaled corticosteroid-induced oropharyngeal adverse events: Results from a meta-analysis. Ann Allergy Asthma Immunol 98:225-238, 2007.
    • (2007) Ann Allergy Asthma Immunol , vol.98 , pp. 225-238
    • Rachelefsky, G.S.1    Liao, Y.2    Faruqi, R.3
  • 18
    • 1642546489 scopus 로고    scopus 로고
    • Inhaled corticosteroids: Why do physicians and patients fail to comply with guidelines for managing asthma?
    • Reed CE. Inhaled corticosteroids: Why do physicians and patients fail to comply with guidelines for managing asthma? Mayo Clin Proc 79:453-455, 2004.
    • (2004) Mayo Clin Proc , vol.79 , pp. 453-455
    • Reed, C.E.1
  • 19
    • 3242734980 scopus 로고    scopus 로고
    • The local side effects of inhaled corticosteroids: Current understanding and review of the literature
    • Roland NJ, Bhalla RK, and Earis J. The local side effects of inhaled corticosteroids: Current understanding and review of the literature. Chest 126:213-219, 2004.
    • (2004) Chest , vol.126 , pp. 213-219
    • Roland, N.J.1    Bhalla, R.K.2    Earis, J.3
  • 20
    • 33745601984 scopus 로고    scopus 로고
    • 2-D and 3-D imaging show ciclesonide has high lung deposition and peripheral distribution: A nonrandomized study in healthy volunteers
    • Leach C, Bethke T, and Boudreau R. 2-D and 3-D imaging show ciclesonide has high lung deposition and peripheral distribution: A nonrandomized study in healthy volunteers. J Aerosol Med 19:117-126, 2006.
    • (2006) J Aerosol Med , vol.19 , pp. 117-126
    • Leach, C.1    Bethke, T.2    Boudreau, R.3
  • 21
    • 1542559715 scopus 로고    scopus 로고
    • PK/PD of inhaled corticosteroids: The risk/benefit of inhaled ciclesonide
    • Abs 598
    • Rohatagi S, Derendorf H, Zech K, et al. PK/PD of inhaled corticosteroids: The risk/benefit of inhaled ciclesonide. J Allergy Clin Immunol 111:S380, 2003 (Abs 598).
    • (2003) J Allergy Clin Immunol , vol.111
    • Rohatagi, S.1    Derendorf, H.2    Zech, K.3
  • 22
    • 32644435870 scopus 로고    scopus 로고
    • High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma
    • Newman S, Salmon A, Nave R, et al. High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 100:375-384, 2006.
    • (2006) Respir Med , vol.100 , pp. 375-384
    • Newman, S.1    Salmon, A.2    Nave, R.3
  • 23
    • 11144349963 scopus 로고    scopus 로고
    • Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide: Results from a pooled analysis
    • Abs 37
    • Engelstaetter R, Banerji D, Steinijans V, et al. Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide: Results from a pooled analysis. Am J Respir Crit Care Med 169:A72, 2004 (Abs 37).
    • (2004) Am J Respir Crit Care Med , vol.169
    • Engelstaetter, R.1    Banerji, D.2    Steinijans, V.3
  • 24
    • 16244383798 scopus 로고    scopus 로고
    • The incidence of oropharyngeal adverse events in adolescent/adults and pediatric asthma patients is similar for ciclesonide and placebo: Results from pooled analyses
    • Banerji D, Szwarcberg J, Fish J, et al. The incidence of oropharyngeal adverse events in adolescent/adults and pediatric asthma patients is similar for ciclesonide and placebo: Results from pooled analyses. Allergy Asthma Proc 25:P206, 2004.
    • (2004) Allergy Asthma Proc , vol.25
    • Banerji, D.1    Szwarcberg, J.2    Fish, J.3
  • 26
    • 20044369411 scopus 로고    scopus 로고
    • Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects
    • Nave R, Zech K, and Bethke TD. Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects. Eur J Clin Pharmacol 61:203-208, 2005.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 203-208
    • Nave, R.1    Zech, K.2    Bethke, T.D.3
  • 27
    • 16244397682 scopus 로고    scopus 로고
    • Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma
    • Richter K, Kanniess F, Biberger C, et al. Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma. J Clin Pharmacol 45:146-152, 2005.
    • (2005) J Clin Pharmacol , vol.45 , pp. 146-152
    • Richter, K.1    Kanniess, F.2    Biberger, C.3
  • 28
    • 29144449973 scopus 로고    scopus 로고
    • Comparison of the efficacy of ciclesonide 160 microg QD and budesonide 200 microg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study
    • Niphadkar P, Jagannath K, Joshi JM, et al. Comparison of the efficacy of ciclesonide 160 microg QD and budesonide 200 microg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study. Clin Ther 27:1752-1763, 2005.
    • (2005) Clin Ther , vol.27 , pp. 1752-1763
    • Niphadkar, P.1    Jagannath, K.2    Joshi, J.M.3
  • 29
    • 0034910074 scopus 로고    scopus 로고
    • Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening
    • Postma DS, Sevette C, Martinat Y, et al. Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening. Eur Respir J 17:1083-1088, 2001.
    • (2001) Eur Respir J , vol.17 , pp. 1083-1088
    • Postma, D.S.1    Sevette, C.2    Martinat, Y.3
  • 30
    • 24344444433 scopus 로고    scopus 로고
    • Once-daily ciclesonide 80 or 320 microg for 12 weeks is safe and effective in patients with persistent asthma
    • Langdon CG, Adler M, Mehra S, et al. Once-daily ciclesonide 80 or 320 microg for 12 weeks is safe and effective in patients with persistent asthma. Respir Med 99:1275-1285, 2005.
    • (2005) Respir Med , vol.99 , pp. 1275-1285
    • Langdon, C.G.1    Adler, M.2    Mehra, S.3
  • 31
    • 14344250921 scopus 로고    scopus 로고
    • Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma
    • Chapman KR, Patel P, D'Urzo AD, et al. Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma. Allergy 60:330-337, 2005.
    • (2005) Allergy , vol.60 , pp. 330-337
    • Chapman, K.R.1    Patel, P.2    D'Urzo, A.D.3
  • 32
    • 33747156391 scopus 로고    scopus 로고
    • Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma
    • Buhl R, Vinkler I, Magyar P, et al. Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma. Pulm Pharmacol Ther 19:404-412, 2006.
    • (2006) Pulm Pharmacol Ther , vol.19 , pp. 404-412
    • Buhl, R.1    Vinkler, I.2    Magyar, P.3
  • 33
    • 28444446289 scopus 로고    scopus 로고
    • Once-daily ciclesonide improves lung function and is well tolerated by patients with mild-to-moderate persistent asthma
    • Pearlman DS, Berger WE, Kerwin E, et al. Once-daily ciclesonide improves lung function and is well tolerated by patients with mild-to-moderate persistent asthma. J Allergy Clin Immunol 116:1206-1212, 2005.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1206-1212
    • Pearlman, D.S.1    Berger, W.E.2    Kerwin, E.3
  • 34
    • 68249143395 scopus 로고    scopus 로고
    • Efficacy and safety evaluation of ciclesonide in subjects with mild-to-moderate asthma not currently using inhaled corticosteroids
    • Berger WE, Kerwin E, Bernstein DI, et al. Efficacy and safety evaluation of ciclesonide in subjects with mild-to-moderate asthma not currently using inhaled corticosteroids. Allergy Asthma Proc 30:304-314, 2009.
    • (2009) Allergy Asthma Proc , vol.30 , pp. 304-314
    • Berger, W.E.1    Kerwin, E.2    Bernstein, D.I.3
  • 35
    • 68249151172 scopus 로고    scopus 로고
    • Efficacy and safety evaluation of ciclesonide in mild-to-moderate persistent asthma previously treated with inhaled corticosteroids
    • Meltzer EO, Korenblat PE, Weinstein SF, et al. Efficacy and safety evaluation of ciclesonide in mild-to-moderate persistent asthma previously treated with inhaled corticosteroids. Allergy Asthma Proc 39:293-303, 2009.
    • (2009) Allergy Asthma Proc , vol.39 , pp. 293-303
    • Meltzer, E.O.1    Korenblat, P.E.2    Weinstein, S.F.3
  • 36
    • 49149100417 scopus 로고    scopus 로고
    • Long-term safety profile of once-daily ciclesonide in adults/adolescents with mild-to-moderate persistent asthma
    • Abs 133
    • Berger W, Galant S, Kundu S, et al. Long-term safety profile of once-daily ciclesonide in adults/adolescents with mild-to-moderate persistent asthma. Ann Allergy Asthma Immunol 96:140, 2006 (Abs 133).
    • (2006) Ann Allergy Asthma Immunol , vol.96 , pp. 140
    • Berger, W.1    Galant, S.2    Kundu, S.3
  • 37
    • 20944444681 scopus 로고    scopus 로고
    • Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma
    • Lipworth BJ, Kaliner MA, LaForce CF, et al. Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma. Ann Allergy Asthma Immunol 94:465-472, 2005.
    • (2005) Ann Allergy Asthma Immunol , vol.94 , pp. 465-472
    • Lipworth, B.J.1    Kaliner, M.A.2    LaForce, C.F.3
  • 38
    • 33645888108 scopus 로고    scopus 로고
    • Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma
    • Boulet LP, Drollmann A, Magyar P, et al. Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma. Respir Med 100:785-794, 2006.
    • (2006) Respir Med , vol.100 , pp. 785-794
    • Boulet, L.P.1    Drollmann, A.2    Magyar, P.3
  • 39
    • 33846805807 scopus 로고    scopus 로고
    • The novel inhaled corticosteroid ciclesonide is efficacious and has a favourable safety profile in adults and adolescents with severe persistent asthma
    • Abs 846
    • Busse W, Kaliner M, Bernstein D, et al. The novel inhaled corticosteroid ciclesonide is efficacious and has a favourable safety profile in adults and adolescents with severe persistent asthma. J Allergy Asthma Immunol 115:S213, 2005 (Abs 846).
    • (2005) J Allergy Asthma Immunol , vol.115
    • Busse, W.1    Kaliner, M.2    Bernstein, D.3
  • 40
    • 33846804261 scopus 로고    scopus 로고
    • Ciclesonide HFA-MDI has a lower incidence of oral candidiasis that beclomethasone dipropionate HFA-MDI in patients with severe persistent asthma: Results of a long-term study
    • Abs P171
    • Korenblat P, Bernstein D, Fish J, et al. Ciclesonide HFA-MDI has a lower incidence of oral candidiasis that beclomethasone dipropionate HFA-MDI in patients with severe persistent asthma: Results of a long-term study. Ann Allergy Asthma Immunol 94:173, 2005 (Abs P171).
    • (2005) Ann Allergy Asthma Immunol , vol.94 , pp. 173
    • Korenblat, P.1    Bernstein, D.2    Fish, J.3
  • 41
    • 18144383000 scopus 로고    scopus 로고
    • Short-term lower-leg growth rate and urine cortisol excretion in children treated with ciclesonide
    • Agertoft L, and Pedersen S. Short-term lower-leg growth rate and urine cortisol excretion in children treated with ciclesonide. J Allergy Clin Immunol 115:940-945, 2005.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 940-945
    • Agertoft, L.1    Pedersen, S.2
  • 42
    • 33646176778 scopus 로고    scopus 로고
    • Once-daily ciclesonide in children: Efficacy and safety in asthma
    • Gelfand EW, Georgitis JW, Noonan M, et al. Once-daily ciclesonide in children: Efficacy and safety in asthma. J Pediatr 148:377-383, 2006.
    • (2006) J Pediatr , vol.148 , pp. 377-383
    • Gelfand, E.W.1    Georgitis, J.W.2    Noonan, M.3
  • 43
    • 49149087719 scopus 로고    scopus 로고
    • Long-term safety profile of once-daily ciclesonide in children with persistent asthma of all severities
    • Abs 134
    • Meltzer E, Sotomayor J, Kundu S, et al. Long-term safety profile of once-daily ciclesonide in children with persistent asthma of all severities. Ann Allergy Asthma Immunol 96:140-141, 2006 (Abs 134).
    • (2006) Ann Allergy Asthma Immunol , vol.96 , pp. 140-141
    • Meltzer, E.1    Sotomayor, J.2    Kundu, S.3
  • 44
    • 33749565533 scopus 로고    scopus 로고
    • A comparative study of inhaled ciclesonide 160 microg/day and fluticasone propionate 176 microg/day in children with asthma
    • Pedersen S, Garcia ML, Manjra A, et al. A comparative study of inhaled ciclesonide 160 microg/day and fluticasone propionate 176 microg/day in children with asthma. Pediatr Pulmonol 41:954-961, 2006.
    • (2006) Pediatr Pulmonol , vol.41 , pp. 954-961
    • Pedersen, S.1    Garcia, M.L.2    Manjra, A.3
  • 45
    • 0033160997 scopus 로고    scopus 로고
    • Absolute oral versus inhaled bioavailability: Significance for inhaled drugs with special reference to inhaled glucocorticoids
    • Rohatagi S, Rhodes GR, and Chaikin P. Absolute oral versus inhaled bioavailability: Significance for inhaled drugs with special reference to inhaled glucocorticoids. J Clin Pharmacol 39:661-663, 1999.
    • (1999) J Clin Pharmacol , vol.39 , pp. 661-663
    • Rohatagi, S.1    Rhodes, G.R.2    Chaikin, P.3
  • 46
    • 0345733708 scopus 로고    scopus 로고
    • Risk-benefit value of inhaled glucocorticoids: A pharmacokinetic/pharmacodynamic perspective
    • Rohatagi S, Appajosyula S, Derendorf H, et al. Risk-benefit value of inhaled glucocorticoids: A pharmacokinetic/pharmacodynamic perspective. J Clin Pharmacol 44:37-47, 2004.
    • (2004) J Clin Pharmacol , vol.44 , pp. 37-47
    • Rohatagi, S.1    Appajosyula, S.2    Derendorf, H.3
  • 47
    • 20444466142 scopus 로고    scopus 로고
    • Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide
    • Rohatagi S, Luo Y, Shen L, et al. Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide. Am J Ther 12:201-209, 2005.
    • (2005) Am J Ther , vol.12 , pp. 201-209
    • Rohatagi, S.1    Luo, Y.2    Shen, L.3
  • 48
    • 2642522877 scopus 로고    scopus 로고
    • Pharmacokinetics of [14C]ciclesonide after oral and intravenous administration to healthy subjects
    • Nave R, Bethke TD, van Marle SP, et al. Pharmacokinetics of [14C]ciclesonide after oral and intravenous administration to healthy subjects. Clin Pharmacokinet 43:479-486, 2004.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 479-486
    • Nave, R.1    Bethke, T.D.2    van Marle, S.P.3
  • 49
    • 34248379654 scopus 로고    scopus 로고
    • Advances in single-entity inhaled corticosteroid therapy
    • Tayab ZR, and Hochhaus G. Advances in single-entity inhaled corticosteroid therapy. Allergy Asthma Proc 28:125-135, 2007.
    • (2007) Allergy Asthma Proc , vol.28 , pp. 125-135
    • Tayab, Z.R.1    Hochhaus, G.2
  • 50
    • 0012614672 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects
    • Nave R, Bethke T, Seiberling M, et al. Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects. Eur Respir J 20(suppl 38):P749, 2002.
    • (2002) Eur Respir J , vol.20 , Issue.SUPPL. 38
    • Nave, R.1    Bethke, T.2    Seiberling, M.3
  • 51
    • 34249060227 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide
    • Derendorf H. Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide. J Clin Pharmacol 47:782-789, 2007.
    • (2007) J Clin Pharmacol , vol.47 , pp. 782-789
    • Derendorf, H.1
  • 52
    • 0027981939 scopus 로고
    • Hypothalamic-pituitary-adrenal axis
    • Honour JW. Hypothalamic-pituitary-adrenal axis. Respir Med 88(suppl A):9-13, 1994.
    • (1994) Respir Med , vol.88 , Issue.SUPPL. A , pp. 9-13
    • Honour, J.W.1
  • 53
    • 0002436880 scopus 로고    scopus 로고
    • Disturbances of the stress response: The role of the HPA axis during alcohol withdrawal and abstinence
    • Adinoff B, Iranmanesh A, Veldhuis J, et al. Disturbances of the stress response: The role of the HPA axis during alcohol withdrawal and abstinence. Alcohol Health Res World 22:67-72, 1998.
    • (1998) Alcohol Health Res World , vol.22 , pp. 67-72
    • Adinoff, B.1    Iranmanesh, A.2    Veldhuis, J.3
  • 54
    • 0042235397 scopus 로고    scopus 로고
    • Potential adverse effects of the inhaled corticosteroids
    • Kelly HW, and Nelson HS. Potential adverse effects of the inhaled corticosteroids. J Allergy Clin Immunol 112:469-478, 2003.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 469-478
    • Kelly, H.W.1    Nelson, H.S.2
  • 55
    • 0041735123 scopus 로고    scopus 로고
    • Inhaled corticosteroids: Past lessons and future issues
    • Allen DB, Bielory L, Derendorf H, et al. Inhaled corticosteroids: Past lessons and future issues. J Allergy Clin Immunol 112(suppl 3):S1-S40, 2003.
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.SUPPL. 3
    • Allen, D.B.1    Bielory, L.2    Derendorf, H.3
  • 56
    • 33846821875 scopus 로고    scopus 로고
    • Evaluation of tests of hypothalamic- pituitary-adrenal axis function used to measure effects of inhaled corticosteroids
    • Bernstein DI, and Allen DB. Evaluation of tests of hypothalamic- pituitary-adrenal axis function used to measure effects of inhaled corticosteroids. Ann Allergy Asthma Immunol 98:118-127, 2007.
    • (2007) Ann Allergy Asthma Immunol , vol.98 , pp. 118-127
    • Bernstein, D.I.1    Allen, D.B.2
  • 57
    • 18344393060 scopus 로고    scopus 로고
    • Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide
    • Weinbrenner A, Huneke D, Zschiesche M, et al. Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide. J Clin Endocrinol Metab 87:2160-2163, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2160-2163
    • Weinbrenner, A.1    Huneke, D.2    Zschiesche, M.3
  • 58
    • 20444415685 scopus 로고    scopus 로고
    • Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to adenosine 5′monophosphate in asthmatic patients
    • Derom E, Van De Velde V, Marissens S, et al. Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to adenosine 5′monophosphate in asthmatic patients. Pulm Pharmacol Ther 18:328-336, 2005.
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 328-336
    • Derom, E.1    Van De Velde, V.2    Marissens, S.3
  • 59
    • 33745959255 scopus 로고    scopus 로고
    • A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma
    • Hansel TT, Benezet O, Kafe H, et al. A multinational, 12-week, randomized study comparing the efficacy and tolerability of ciclesonide and budesonide in patients with asthma. Clin Ther 28:906-920, 2006.
    • (2006) Clin Ther , vol.28 , pp. 906-920
    • Hansel, T.T.1    Benezet, O.2    Kafe, H.3
  • 60
    • 0038075512 scopus 로고    scopus 로고
    • Effect of ciclesonide on allergen challenge in subjects with bronchial asthma
    • Larsen BB, Nielsen LP, Engelstatter R, et al. Effect of ciclesonide on allergen challenge in subjects with bronchial asthma. Allergy 58:207-212, 2003.
    • (2003) Allergy , vol.58 , pp. 207-212
    • Larsen, B.B.1    Nielsen, L.P.2    Engelstatter, R.3
  • 61
    • 15844377108 scopus 로고    scopus 로고
    • Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma
    • Lee DK, Fardon TC, Bates CE, et al. Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma. Chest 127:851-860, 2005.
    • (2005) Chest , vol.127 , pp. 851-860
    • Lee, D.K.1    Fardon, T.C.2    Bates, C.E.3
  • 62
    • 20444468843 scopus 로고    scopus 로고
    • Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma
    • Szefler S, Rohatagi S, Williams J, et al. Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma. Chest 128:1104-1114, 2005.
    • (2005) Chest , vol.128 , pp. 1104-1114
    • Szefler, S.1    Rohatagi, S.2    Williams, J.3
  • 63
    • 57749195892 scopus 로고    scopus 로고
    • Ciclesonide does not suppress the hypothalamic-pituitary-adrenal axis function in patients with severe persistent asthma: Results of a long-term study
    • Abs P164
    • Nayak A, Nathan R, Williams J, et al. Ciclesonide does not suppress the hypothalamic-pituitary-adrenal axis function in patients with severe persistent asthma: Results of a long-term study. Ann Allergy Asthma Immunol 94:171-172, 2005 (Abs P164).
    • (2005) Ann Allergy Asthma Immunol , vol.94 , pp. 171-172
    • Nayak, A.1    Nathan, R.2    Williams, J.3
  • 64
    • 33750696639 scopus 로고    scopus 로고
    • Low-dose inhaled and nasal corticosteroid use and the risk of cataracts
    • Ernst P, Baltzan M, Deschenes J, et al. Low-dose inhaled and nasal corticosteroid use and the risk of cataracts. Eur Respir J 27:1168-1174, 2006.
    • (2006) Eur Respir J , vol.27 , pp. 1168-1174
    • Ernst, P.1    Baltzan, M.2    Deschenes, J.3
  • 65
    • 33645750002 scopus 로고    scopus 로고
    • Risk of cataracts and glaucoma with inhaled steroid use in children
    • Nootheti S, and Bielory L. Risk of cataracts and glaucoma with inhaled steroid use in children. Compr Ophthalmol Update 7:31-39, 2006.
    • (2006) Compr Ophthalmol Update , vol.7 , pp. 31-39
    • Nootheti, S.1    Bielory, L.2
  • 66
    • 33646500982 scopus 로고    scopus 로고
    • Effect of inhaled corticosteroids on risk of development of cataract: A meta-analysis
    • Uboweja A, Malhotra S, and Pandhi P. Effect of inhaled corticosteroids on risk of development of cataract: A meta-analysis. Fundam Clin Pharmacol 20:305-309, 2006.
    • (2006) Fundam Clin Pharmacol , vol.20 , pp. 305-309
    • Uboweja, A.1    Malhotra, S.2    Pandhi, P.3
  • 67
    • 57749186647 scopus 로고    scopus 로고
    • A randomized, controlled trial to investigate the effect of ciclesonide and beclomethasone dipropionate on eye lens
    • Chylack L, Gross G, and Pedinoff A. A randomized, controlled trial to investigate the effect of ciclesonide and beclomethasone dipropionate on eye lens. J Asthma 45:893-902, 2008.
    • (2008) J Asthma , vol.45 , pp. 893-902
    • Chylack, L.1    Gross, G.2    Pedinoff, A.3
  • 68
    • 38049050194 scopus 로고    scopus 로고
    • Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma
    • Skoner D, Maspero J, and Banerji D. Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma. Pediatrics 121:e1-e14, 2008.
    • (2008) Pediatrics , vol.121
    • Skoner, D.1    Maspero, J.2    Banerji, D.3
  • 69
    • 34248349125 scopus 로고    scopus 로고
    • Advances in inhaled corticosteroid pharmacology
    • Zitt MJ. Advances in inhaled corticosteroid pharmacology. Allergy Asthma Proc 28:114-124, 2007.
    • (2007) Allergy Asthma Proc , vol.28 , pp. 114-124
    • Zitt, M.J.1
  • 70
    • 9644291519 scopus 로고    scopus 로고
    • Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma
    • Williams LK, Pladevall M, Xi H, et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol 114:1288-1293, 2004.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1288-1293
    • Williams, L.K.1    Pladevall, M.2    Xi, H.3
  • 71
    • 0030935040 scopus 로고    scopus 로고
    • Adult patients may outgrow their asthma: A 25-year follow-up study
    • Panhuysen CI, Vonk JM, Koeter GH, et al. Adult patients may outgrow their asthma: A 25-year follow-up study. Am J Respir Crit Care Med 155:1267-1272, 1997.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1267-1272
    • Panhuysen, C.I.1    Vonk, J.M.2    Koeter, G.H.3
  • 72
    • 0028235803 scopus 로고
    • Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children
    • Agertoft L, and Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 88:373-381, 1994.
    • (1994) Respir Med , vol.88 , pp. 373-381
    • Agertoft, L.1    Pedersen, S.2
  • 73
    • 4544388874 scopus 로고    scopus 로고
    • Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function
    • Lee DK, Bates CE, Currie GP, et al. Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function. Ann Allergy Asthma Immunol 93:253-258, 2004.
    • (2004) Ann Allergy Asthma Immunol , vol.93 , pp. 253-258
    • Lee, D.K.1    Bates, C.E.2    Currie, G.P.3
  • 74
    • 0030690497 scopus 로고    scopus 로고
    • Effects of airway calibre on lung delivery of nebulised salbutamol
    • Lipworth BJ and Clark DJ. Effects of airway calibre on lung delivery of nebulised salbutamol. Thorax 52(12):1036-1039, 1997.
    • (1997) Thorax , vol.52 , Issue.12 , pp. 1036-1039
    • Lipworth, B.J.1    Clark, D.J.2
  • 75
    • 4043140973 scopus 로고    scopus 로고
    • Ciclesonide has no effect on hypothalamic-pituitary-adrenal (HPA)-axis at once-daily doses of 80 μg, 160 μg or 320 μg in the treatment of patients with mild-to-moderate asthma
    • Abs
    • Kerwin E, Chervinsky P, Fish J, et al. Ciclesonide has no effect on hypothalamic-pituitary-adrenal (HPA)-axis at once-daily doses of 80 μg, 160 μg or 320 μg in the treatment of patients with mild-to-moderate asthma. Am J Respir Crit Care Med 169:90, 2004 (Abs).
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 90
    • Kerwin, E.1    Chervinsky, P.2    Fish, J.3
  • 76
    • 73449106969 scopus 로고    scopus 로고
    • Once-daily ciclesonide does not cause HPA-axis suppression in pediatric asthma patients
    • Abs
    • Georgitis J, Galant S, and Lloyd M. Once-daily ciclesonide does not cause HPA-axis suppression in pediatric asthma patients. Ped Critical Care Med 5:511, 2004 (Abs).
    • (2004) Ped Critical Care Med , vol.5 , pp. 511
    • Georgitis, J.1    Galant, S.2    Lloyd, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.