EphrinB reverse signaling in cell-cell adhesion: Is it just par for the course?

Cell Adhesion and Migration

Volumn 3, Issue 3, 2009, Pages 250-255

  Lee, Hyun Shik ^a   Daar, Ira O ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cell cell adhesion; Eph; Ephrin; Par 6; Tight junctions

Indexed keywords

EPHRIN B1; EPHRIN B2; EPHRIN B3; EPHRIN RECEPTOR; PROTEIN CDC42; PROTEIN PAR 6; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 3; UNCLASSIFIED DRUG;

CELL ADHESION; CELL JUNCTION; EPITHELIUM CELL; HUMAN; NONHUMAN; NOTE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION; XENOPUS;

EID: 68249120306     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.3.3.8211     Document Type: Note

References (41)

1. Perez-Moreno M, Jamora C, Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 2003; 112:535-548 (Pubitemid 36263085)
2. Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. Deconstructing the cadherincatenin-actin complex. Cell 2005; 123:889-901.
3. Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 2005; 123:903-915 (Pubitemid 41721035)
4. Cortina C, Palomo-Ponce S, Iglesias M, Fernandez-Masip JL, Vivancos A, Whissell G, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet 2007; 39:1376-1383 (Pubitemid 350034995)
5. Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani-Seiki M, Kondoh H, et al. Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell 2005; 8:587-598 (Pubitemid 40450747)
6. Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 2005; 6:462-475
7. Wimmer-Kleikamp SH, Lackmann M. Eph-modulated cell morphology, adhesion and motility in carcinogenesis. IUBMB Life 2005; 57:421-431 (Pubitemid 41073124)
8. Poliakov A, Cotrina M, Wilkinson DG. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev Cell 2004; 7:465-480 (Pubitemid 39341833)
9. Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 2004; 7:501-509 (Pubitemid 38544589)
10. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, et al. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 2001; 105:233-244 (Pubitemid 32429513)
11. Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M, Mochizuki N. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res 2003; 93:23-31. (Pubitemid 36859037)
12. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, et al. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron 2005; 46:205-217 (Pubitemid 40545777)
13. Yamaguchi Y, Irie F. [Roles of Eph receptors and the cell surface heparan sulfate proteoglycan syndecan-2 in dendritic spine morphogenesis]. Seikagaku 2002; 74:391-395
14. Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, et al. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 2003; 37:263-274 (Pubitemid 36143821)
15. Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, et al. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. Embo J 1997; 16:3877-3888 (Pubitemid 27281004)
16. Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 1996; 383:722-725 (Pubitemid 26360649)
17. Bruckner K, Pasquale EB, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 1997; 275:1640-1643 (Pubitemid 27120539)
18. Lee HS, Mood K, Battu G, Ji YJ, Singh A, Daar IO. FGF Receptor-Induced Phosphorylation of EphrinB1 Modulates its Interaction with Dishevelled. Mol Biol Cell 2009; 20: 124-133
19. Moore KB, Mood K, Daar IO, Moody SA. Morphogenetic movements underlying eye field formation require interactions between the FGF and ephrinB1 signaling pathways. Dev Cell 2004; 6:55-67. (Pubitemid 38089205)
20. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 1999; 13:295-306. (Pubitemid 29095801)
21. Cowan CA, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature 2001; 413:174-179 (Pubitemid 32867879)
22. Segura I, Essmann CL, Weinges S, Acker-Palmer A. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat Neurosci 2007; 10:301-310 (Pubitemid 46310476)
23. Bong YS, Lee HS, Carim-Todd L, Mood K, Nishanian TG, Tessarollo L, Daar IO. ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci USA 2007; 104:17305-17310 (Pubitemid 350219838)
24. Lu Q, Sun EE, Klein RS, Flanagan JG. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell 2001; 105:69-79. (Pubitemid 32323917)
25. Tanaka M, Kamo T, Ota S, Sugimura H. Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. Embo J 2003; 22:847-858 (Pubitemid 36227787)
26. Lee HS, Bong YS, Moore KB, Soria K, Moody SA, Daar IO. Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway. Nat Cell Biol 2006; 8:55-63. (Pubitemid 43064797)
27. Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Mol Neurodegener 2006;1:2.
28. Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J 2006;25:1242-1252
29. Tanaka M, Kamata R, Sakai R. Phosphorylation of ephrin-B1 via the interaction with claudin following cell-cell contact formation. EMBO J 2005; 24:3700-3711 (Pubitemid 41581687)
30. Lee HS, Nishanian TG, Mood K, Bong YS, Daar IO. EphrinB1 controls cell-cell junctions through the Par polarity complex. Nat Cell Biol 2008; 10:979-986
31. Wang Q, Margolis B. Apical junctional complexes and cell polarity. Kidney Int 2007. (Pubitemid 350197955)
32. Davy A, Bush JO, Soriano P. Inhibition of gap junction communication at ectopic Eph/ ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol 2006; 4:315. (Pubitemid 44610095)
33. Harris KP, Tepass U. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol 2008; 183:1129-1143
34. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol 2008; 18:1631-1638
35. Leibfried A, Fricke R, Morgan MJ, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol 2008; 18:1639-1648
36. Mellitzer G, Xu Q, Wilkinson DG. Eph receptors and ephrins restrict cell intermingling and communication. Nature 1999; 400:77-81. (Pubitemid 29315114)
37. Elias LA, Wang DD, Kriegstein AR. Gap junction adhesion is necessary for radial migration in the neocortex. Nature 2007; 448:901-907
38. Xu X, Francis R, Wei CJ, Linask KL, Lo CW. Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development 2006; 133:3629-3639 (Pubitemid 44614285)
39. Xu X, Li WE, Huang GY, Meyer R, Chen T, Luo Y, et al. Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. J Cell Biol 2001; 154:217-230 (Pubitemid 34289290)
40. Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, et al. EphB receptor activity suppresses colorectal cancer progression. Nature 2005; 435:1126-1130 (Pubitemid 40910522)
41. Clevers, H, Batlle, E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res 2006; 66:2-5. (Pubitemid 43165998)