Biodegradable thermogelling hydrogel of P(CL-GL)-PEG-P(CL-GL) triblock copolymer: Degradation and drug release behavior

Journal of Pharmaceutical Sciences

Volumn 98, Issue 8, 2009, Pages 2603-2610

  Jiang, Zhiqiang ^a,b   Hao, Jianyuan ^a   You, Yujing ^c   Gu, Qun ^b   Cao, Weiming ^a   Deng, Xianmo ^a  

^a CHENGDU INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b NINGBO INSTITUTE OF MATERIALS TECHNOLOGY AND ENGINEERING   (China)

^c TAIZHOU UNIVERSITY   (China)

Author keywords

Block copolymer; Bovine serum albumin; Degradation; Drug release; Isoniazid; Rifampicin; Thermogelling hydrogel

Indexed keywords

BOVINE SERUM ALBUMIN; COPOLYMER; ISONIAZID; POLY(EPSILON CAPROLACTONE CO GLYCOLIDE)POLY(ETHYLENE GLYCOL)POLY(EPSILON CAPROLACTONE CO GLYCOLIDE); RIFAMPICIN; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIODEGRADABILITY; BODY TEMPERATURE; CONTROLLED RELEASE FORMULATION; DRUG DEGRADATION; DRUG RELEASE; DRUG SYNTHESIS; HYDROGEL; PH MEASUREMENT; PHASE TRANSITION; POLYMER PRODUCTION; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; STRUCTURE ANALYSIS;

EID: 68249114966     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21613     Document Type: Article

References (21)

1. Peppas NA, Bures P, Leobandung W, Ichikawa H. 2000. Hydrogels in pharmaceutical formulations. Eur J Pharmacol 50:27-46.
2. Kitano M, Mitani Y, Takayama K, Nagai T. 1998. Buccal absorption of golden hamster cheek in vitro and in vivo of 17b-estradiol from hydrogels containing three types of absorption enhancers. Int J Pharm 174:19-28. (Pubitemid 28486985)
3. Remunan-Lopez C, Portero A, Vila-Jato JL, Alonso MJ. 1998. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J Control Release 55:143-152. (Pubitemid 28477605)
4. Ryu JM, Chung SJ, Lee MH, Kim CK, Shim CK. 1999. Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum. J Control Release 59:163-172.
5. Cohen S, Lobel E, Trevgoda A, Peled T. 1997. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. J Control Release 44:201-208. (Pubitemid 27039116)
6. Carlfors J, Edsman K, Petersson R, JoÈrnving K. 1998. Rheological evaluation of Gelritew in situ gels for ophthalmic use. Eur J Pharm Sci 6:113-119. (Pubitemid 28164281)
7. Prashant DS, Hosur NA, Shabbir MM. 2006. Two-step protocol to incorporate cells in thermoresponsive hydrogels. Biotechnol J 1:462-465.
8. Blanco MD, García O, Trigo RM, Teijón JM, Katime I. 1996. 5-Fluorouracil release from copolymeric hydrogels of itaconic acid monoester. I. Acrylamide-co-monomethyl itaconate. Biomaterials 17: 1061-1067.
9. Giammona G, Pitarresi G, Tomarchio V, Spampinato S, Govoni P, Campana T. 1996. New hydrogel matrices based on chemical crosslinked a,b- polyasparthydrazide: Synthesis, characterization and in vivo biocompatibility studies. Int J Pharm 127:165-175. (Pubitemid 26092134)
10. Teijón JM, Trigo RM, García O, Blanco MD. 1997. Cytarabine trapping in poly(2-hydroxyethyl methacrylate) hydrogels: Drug delivery studies. Biomaterials 18:383-388. (Pubitemid 27095584)
11. Tipton AJ, Dunn RL. 2000. In situ gelling systems. In: Senior JH, Radomsky M, editors. Sustained release injectable products. Denver, CO: Interpharm Press. pp. 71-102.
12. Levy RJ, Vinod L, Strickberger SA, Underwood T, Davis J. 1996. Controlled release implant dosage forms for cardiacarrhythmias: Review and perspectives. Drug Deliv 3:137-142. (Pubitemid 26343093)
13. Jeong B, Bae YH, Lee DS, Kim SW. 1997. Biodegradable block copolymers as injectable drug delivery systems. Nature 388:860-862. (Pubitemid 27377054)
14. Jeong B, Bae YH, Kim SW. 1999. Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions. Macromolecules 32:7064-7069. (Pubitemid 32079730)
15. Jeong B, Bae YH, Kim SW. 2000. In situ gelation of PEG-PLGA-PEG triblock copolymer aqyeous solution and degradation thereof. J Biomed Mater 50: 171-177.
16. Jeong B, Bae YH, Kim SW. 2000. Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymer. J Control Release 63:155-163. (Pubitemid 30046951)
17. Jeong B, Kibbey MR, Birnbaum JC, Won YY, Gutowska A. 2000. Thermogelling biodegradable polymers with hydrophilic backbones. Macromolecules 33:8317-8322. (Pubitemid 32031177)
18. Vert M, Li S, Garreau H. 1996. More about the degradation of LA/GA-derived matrices in aqueous media. J Control Release 16:15-26.
19. Mader K, Gallez B, Liu KJ, Swartz HM. 1996. Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy. Biomaterials 17:457-461. (Pubitemid 26047499)
20. Jiang Z, You Y, Deng XM, Hao JY. 2007. Injectable hydrogels of poly(ε-caprolactone-coglycolide)-co-poly(ethylene glycol)-poly(ε- caprolactone-co-glycolide) triblock copolymer aqueous solutions. Polymer 48:4786-4792. (Pubitemid 47069494)
21. Alexandrisdis P, Holzwarth JF, Hatton TA. 1994. Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association. Macromolecules 27:2414-2425.