Cytarabine trapping in poly(2-hydroxyethyl methacrylate) hydrogels: Drug delivery studies

Biomaterials

Volumn 18, Issue 5, 1997, Pages 383-388

  Teijon J M ^a   Trigo, R M ^a   Garcia O ^a   Blanco, M D ^a  

^a NONE

Author keywords

Controlled release; Cytarabine; Diffusion coefficients; Hydrogels; pHEMA

Indexed keywords

BIODEGRADATION; COMPOSITION EFFECTS; CONTROLLED DRUG DELIVERY; CROSSLINKING; DIFFUSION IN LIQUIDS; PHARMACOKINETICS;

CYTARABINE TRAPPING; ETHYLENEGLYCOL DIMETHACRYLATE (EGDMA);

HYDROGELS;

2 HYDROXYETHYL METHACRYLATE; CYTARABINE; CYTOSTATIC AGENT; ETHYLENE GLYCOL; METHACRYLIC ACID;

ARTICLE; CONTROLLED RELEASE FORMULATION; CROSS LINKING; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; POLYMERIZATION; PRIORITY JOURNAL; TIME;

CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; CYTARABINE; DIFFUSION; DRUG DELIVERY SYSTEMS; GELS; METHACRYLATES; POLYHYDROXYETHYL METHACRYLATE; SOLUTIONS;

EID: 0031106904     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(96)00139-1     Document Type: Article

References (37)

1. 1. Calabresi, P. and Parks, R. E., Quimioterapia de las enfernedades neoplásicas. In Las Bases Farmacológicas de la Terapéutica, eds L. Goodman and A. Gilman, Editorial Médica Panamericana, Madrid, 1986, pp. 1179-1240.
2. 2. Chabner, B. A., Citosine arabinoside. In Pharmacologic Principles of Cancer Treatment, ed. B. A. Chabner, Saunders Co., Philadelphia, 1982, 387-401.
3. 3. Heidelberger, C., Pyramidine and pyramidine nucleoside antimetabolites. In Cancer Medicine, eds J. T. Holland and E. Frei, Lea & Febiger, Philadelphia, 1982, pp. 801-823.
4. 4. Capizzi, R. L., White, J. C., Powell, B. L. and Perrino, F., Effect of dose on the pharmacokinetic oral pharmacodynamic effects of cytarabine. Sem Hematol, 1991, 28(4), 54-69.
5. 5. Kufe, D. W., Cytarabine (ara-C) in the treatment of preleukemias. Current Hospital Topics, The Upjohn Company, 1985.
6. 6. Balls, F. M., Holvenberg, J. S. and Bleyer, W. A., Clinical pharmacokinetics of commonly used anticancer drugs. Clin Pharmacokinetics, 1983, 8, 202-232.
7. 7. Capizzi, R. L., Citarabina (ara-C) a dosis alias en las leucemias agudas. Current Hospital Topics, The Upjohn Company, 1985.
8. 8. Marsh, J. H., Kreis, W., Barile, B., Akerman, S., Schulman, P., Allen, S. L., de Marco, L. C., Schuster, M. W. and Budman, D. R., Therapy of refractory/ relapsed acute myeloid leukemia and blast crisis of chronic myeloid leukemia with the combination of cytosine arabinoside, tetrahydrouridine and carboplatin. Cancer Chemother Pharmacol, 1993, 31, 481-484.
9. 9. Wysocki, M., Kurylak, A., Pilecki, O. and Balcar Boron, A., Preliminary evaluation of adverse effects after administration of arabinoside cytosine (ara-C) in high doses to children with acute myelogenous leukemia. Acta Hematol Pol, 1994, 25(1), 37-42.
10. 10. Peyman, G. A., Conway, M., Khoobehi, B. and Soike, K., Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates. Int Ophthalmol, 1992, 16(2), 109-113.
11. 11. Allen, T. M., Mehra, T., Hansen, C. and Chin, Y. C., Stealth liposomes: an improved sustained release system for 1-beta-D-arabinofuranosyl cytosine. Cancer Res, 1992, 52(9), 2431-2439.
12. 12. Onishi, H., Seno, Y., Pithayanukul, P. and Nagai, T., Conjugate of N4-(4-Carboxybutyryl)-ara-C and ethylene-diamine introduced dextran. Drug release profiles and further in vivo study of its antitumor effects. Drug Design Deliv, 1991, 7(2), 139-145.
13. 13. Nishikawa, M., Kamijo, A., Fujita, T., Takakura, Y., Sezaki, H. and Hashida, M., Synthesis and pharmcokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting. Pharm Res, 1993, 10(9), 1253-1261.
14. 14. Montheard, J. P., Chatzopoulos, M. and Chappard, D., 2-hydroxyethyl methacrylate (HEMA): chemical properties and applications in biomedical fields. J Macromol Sci Rev Macromol Chem Phys, 1992, 32, 1-34.
15. 15. García, O., Trigo, R. M., Blanco, M. D. and Teijón, J. M., Influence of crosslinking degree on 5-fluorouracil release from poly(2-hydroxyethyl methacrylate) hydrogels. Biomaterials, 1994, 15, 689-694.
16. 16. Davis, T. P. and Huglin, M. B., Some mechanical properties of poly(2-hydroxyethyl methacrylate) gels swollen in water/1,4-dioxane mixture. Makromol Chem Rapid Commun, 1988, 9, 39-43.
17. 17. Song, S. Z., Cardinal, J. R., Kim, S. H. and Kim, S. W., Progestin permeation through polymer membranes, V. Progesterone release from monolithic hydrogel devices. J Pharm Sci, 1981, 70, 216-219.
18. 18. Trigo, R. M., Blanco, M. D., Teijón, J. M. and Sastre, R., Anticancer drug, ara-C, release from poly(2-hydroxyethyl methacrylate) hydrogels. Biomaterials, 1994, 15, 1181-1186.
19. 19. Quock, J. R. and Sakai, R. I., Stability of cytarabine in a parenteral nutrient solution. Am J Hosp Pharm, 1985, 42, 592-594.
20. 20. Breithaupt, H. and Schick, J., Determination of cytarabine and uracilarabinoside in human plasma and cerebrospinal fluid by high performance liquid chromatography. J Chromatogr, 1981, 225, 99-106.
21. 21. Lee, P. I., Kinetics of drug release from hydrogel matrices. J Controlled Release, 1985, 2, 277-288.
22. 22. Corkhill, P. H., Jolly, A. M., Ng, C. O. and Tighe, B. J., Synthetic hydrogels: 1. Hydroxyalkyl acrylate and methacrylate copolymer-water binding studies. Polymer, 1987, 28, 1758-1766.
23. 23. Davis, T. P. and Huglin, M. B., Effect of crosslinking on the properties of poly(2-hydroxyethyl methacrylate) hydrogels. Angew Makromol Chem, 1991, 189, 195-205.
24. 24. Trigo, R. M., Blanco, M. D., Huerta, P., Olmo, R. and Teijón, J. M., L-Ascorbic acid release from poly(2-hydroxyethyl methacrylate) hydrogels. Polymer Bull, 1993, 31, 577-584.
25. 25. Crank, J. (ed.), The Mathematics of Diffusion, Clarendon Press, Oxford, 1975.
26. 26. Korsmeyer, R. W. and Peppas, N. A., Solute and penetrant diffusion in swellable polymers, III. Drug release from glassy poly(HEMA-co-VP) copolymers. J Controlled Release, 1984, 1, 89-98.
27. 27. Wisniewski, S. J., Gregonis, D. E., Kim, S. W. and Andrade, J. D., Diffusion through hydrogel membranes, 1. Permeation of water through poly(2-hydroxyethyl methacrylate) and related polymers. In Hydrogels for Medical and Related Applications, Vol. 31, ed. J. D. Andrade, ACS Symposium Series 31, American Chemical Society, Washington, 1976, pp. 80-87.
28. 28. Allen, P. E. M., Bennett, D. J. and Williams, D. R. G., Water in methacrylates, I. Sorption and desorption properties of poly(2-hydroxyethyl methacrylate-co-glycol dimethacrylate) network. Eur Polym J, 1992, 28, 347-352.
29. 29. Yean, L., Bunel, C. and Vairon, J. P., Reversible immobilization of drugs on a hydrogel matrix, II. Diffusion of free chloramphenicol from poly(2-hydroxyethyl methacrylate) hydrogels. Makromol Chem, 1990, 191, 1119-1129.
30. 30. Crank, J. and Park, G. S. (eds), Diffusion in Polymers, Academic Press, London, 1968.
31. 31. Huglin, M. B. and Sloan, D. J., Release of ergotamine from poly(2-hydroxyethyl methacrylate). Br Polym J, 1983, 15, 165-171.
32. 32. Robert, C. C. R., Buri, P. A. and Peppas, N. A., Effect of degree of crosslinking on water transport in polymer microparticules. J Appl Polym Sci, 1985, 30, 301-306.
33. 33. Lustig, S. R. and Peppas, N. A., Solute diffusion in swollen membranes, IX. Scaling Locus for solute diffusion in gels. J Appl Polym Sci, 1988, 36, 735-747.
34. 34. Murphy, S. M., Hamilton, C. J. and Tighe, B. J., Synthetic hydrogels: 5. Transport processes in 2-hydroxyethyl methacrylate copolymers. Polymer, 1988, 29, 1887-1893.
35. 35. Wood, J. M., Attwood, D. and Collett, J. H., The influence on gel formulation on the diffusion of salicylic acid in poly(2-hydroxyethyl methacrylate) hydrogels. J Pharm Pharmacol, 1982, 34, 1-4.
36. 36. Denizli, A., Kiremitci, M. and Piskin, E., Subcutaneous polymeric matrix system p(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). II. Release kinetics. Biomaterials, 1978, 9, 363-366.
37. 37. Peppas, N. A., Gurny, R., Doelker, E. and Buri, P., Modeling of drug diffusion through swellable polymeric systems. J Membr Sci, 1980, 7, 241-253.