The development and validation of a computational model to predict rat liver microsomal clearance

Journal of Pharmaceutical Sciences

Volumn 98, Issue 8, 2009, Pages 2857-2867

  Chang, Cheng ^a   Duignan, David B ^a   Johnson, Kjell D ^a   Lee, Pil H ^b,c   Cowan, George S ^b   Gifford, Eric M ^b   Stankovic, Charles J ^a   Lepsy, Christopher S ^a   Stoner, Chad L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

^c Cayman Chemical   (United States)

Author keywords

Clearance; Computational ADME; In silico; Metabolism; Modeling; QSAR

Indexed keywords

ANIMAL TESTING REDUCTION; ARTICLE; BAYES THEOREM; CHEMICAL STRUCTURE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; LIVER CLEARANCE; LIVER MICROSOMAL CLEARANCE; LIVER MICROSOME; METABOLIC CLEARANCE RATE; PRODUCTIVITY; RANDOM FOREST;

EID: 68249106745     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21651     Document Type: Article

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