Clinical implications of genitourinary embryology

Current Opinion in Urology

Volumn 19, Issue 4, 2009, Pages 427-433

  Shapiro, Ellen ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone morphogenetic protein 4; Gremlin 1; Organogenesis; Sonic hedgehog; Urogenital

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CYTOKINE RECEPTOR ANTAGONIST; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREMLIN 1; SLIT2 PROTEIN; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

CONGENITAL MALFORMATION; CORRELATION ANALYSIS; DEVELOPMENT; EMBRYO DEVELOPMENT; EMBRYOLOGY; HUMAN; KIDNEY DEVELOPMENT; MESENCHYME; MOLECULAR BIOLOGY; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION; URETER; URETEROPELVIC JUNCTION; URINARY TRACT; UROGENITAL SYSTEM; UROGENITAL TRACT MALFORMATION; VESICOURETERAL REFLUX;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; HUMANS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; ORGANOGENESIS; SIGNAL TRANSDUCTION; UROGENITAL ABNORMALITIES; UROGENITAL SYSTEM;

EID: 68249091538     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOU.0b013e32832c90ff     Document Type: Review

References (28)

1. Yu J, McMahon AP, Valerius MT. Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 2004; 14:550-557. (Pubitemid 39360303)
2. Michos O, Goncalves A, Lopez-Rios J, et al. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signaling during kidney branching morphogenesis. Development 2007; 134:2397-2405; doi: 10.1242/dev.02861. This paper establishes that the initiation of metanephric kidney development requires reduced BMP activity, which permits ureteral bud outgrowth in a murine model. (Pubitemid 47074134)
3. Glassberg KI. Normal and abnormal development of the kidney: a clinician's interpretation of current knowledge. J Urol 2002; 167:2339-2351.
4. Pichel JG, Shen L, Sheng HZ, et al. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996; 382:73. (Pubitemid 26243360)
5. Schuchardi A, D'Agati V, Panchnis V, et al. Renal agenesis and hypodysplasia in ret-k mutant mice result from defects in ureteric bud development. Development 1996; 122:1919. (Pubitemid 26192756)
6. Grieshammer U, Le M, Plump AS, et al. SLIT2 mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 2004; 6:709-717. (Pubitemid 38579353)
7. Basson MA, Akbulut S, Watson-Johnson J, et al. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 2005; 8:229-239. (Pubitemid 40197739)
8. Majumdar A, Vainio S, Kispert A, et al. Wnt11 and REt/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003; 130:3175-3185. (Pubitemid 36926955)
9. Miyazaki Y, Oshima K, Fogo A, et al. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 2000; 105:863-873. (Pubitemid 30203059)
10. Miyazaki Y, Oshima K, Fogo A, et al. Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int 2003; 63:835-844. (Pubitemid 36315561)
11. Michos O, Panman L, Vintersten K, et al. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 2004; 131:3401-3410. (Pubitemid 39139886)
12. Brenner-Anantharam A, Cebrian C, Guillaume R, et al. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 2007; 134:1967-1975; doi:10.1242/dev.004234. This article investigates the cellular and molecular mechanisms mediating the differentiation of the ureteric bud into the intrarenal collecting system and the ureter in an avian and murine model. (Pubitemid 46939241)
13. Lipschutz JH, Young P, Taguchi O, Cunha GR. Urothelial transformation into functional glandular tissue in situ by instructive mesenchymal induction. Kidney Int 1996; 49:59-66. (Pubitemid 26022828)
14. Wang GJ, Brenner-Anantharam A, Vaughan ED, Herzlinger D. Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junction. J Urol 2009; 181:401-407. This paper examines the effect of disrupting BMP4 signaling on ureteral morphogenesis in a murine model. Their findings of abnormal smooth muscle development have important implications for the cause of UPJ obstruction.
15. Viana R, Batourina E, Huang H, et al. The development of the bladder trigone, the center of the antireflux mechanism. Development 2007; 134:3763-3769; doi: 10.1242/dev. 011270. This article should be reviewed by all students of embryology who are interested in understanding the development of the ureterovesical junction and trigone. (Pubitemid 350104385)
16. Park JM. Normal development of the urogenital system. In: Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA, editors. Campbell-Walsh Urology. 9th ed. Philadelphia: Saunders Elsevier; 2007. pp. 3121-3148.
17. Tanagho EA, Smith DR, Meyers FH. The trigone: anatomical and physiological considerations. 2. In relation to the bladder neck. J Urol 1968; 100:633-639.
18. Woodburne RT. Anatomy of the ureterovesical junction. J Urol 1964; 92:431-435.
19. Tanagho EA, Pugh RC. The anatomy and function of the ureterovesical junction. Br J Urol 1963; 35:151-165.
20. Batourina E, Tsai S, Lambert S, et al. Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet 2005; 37:1082-1089. (Pubitemid 41486660)
21. Yamada G, Satoh Y, Baskin LS, et al. Cellular and molecular mechanisms of development of the external genitalia. Differentiation 2003; 71:445-460. (Pubitemid 37363661)
22. Freestone SH, Marker P, Grace OC, et al. Sonig hedgehog regulates prostatic growth and epithelial differentiation. Dev Biol 2003; 264:352-362. (Pubitemid 37490974)
23. Haraguchi R, Mo R, Hui C, et al. Unique factors of Sonic hedgehog signaling during external genitalia development. Development 2001; 128:4241-4250. (Pubitemid 33077035)
24. Haraguchi R, Montoyama J, Sasaki H, et al. Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 2007; 134:525-533. This article examines mesenchymal precursors from PCM and the role of Shh signaling in the coordination of urogenital organ formation from these precursors. (Pubitemid 46332489)
25. Yamada G, Suzuki K, Haraguchi R, et al. Molecular genetic cascades for external genitalia formation an emerging organogenesis program. Dev Dyn 2006; 5:1738-1752. (Pubitemid 43902334)
26. Baskin LS, Hayward SW, Young P, Cunha GR. Role of mesenchymal-epithelial interactions in normal bladder development. J Urol 1996; 156:1820. (Pubitemid 26344062)
27. Shiroyanagi Y, Liu B, Cao M, et al. Urothelial sonic hedgehog signaling plays an important role in bladder smooth muscle formation. Differentiation 2007; 75:968. (Pubitemid 350212638)
28. Cheng W, Yeugn C-K, Ng Y-K, et al. Sonic hedgehog mediator Gli2 regulates bladder mesenchymal patterning. J Urol 2008; 180:1543-1550. These authors propose a model for mammalian bladder development and suggest that Shh transcriptional factor Gli2 regulates radial patterning of the bladder mesenchyme.