Antagonism of BMP4 Signaling Disrupts Smooth Muscle Investment of the Ureter and Ureteropelvic Junction

Journal of Urology

Volumn 181, Issue 1, 2009, Pages 401-407

  Wang, Gerald J ^a   Brenner Anantharam, Andrea ^a   Vaughan, E Darracott ^a   Herzlinger, Doris ^a  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

abnormalities; bone morphogenetic protein 4; gene expression; ureter; ureteral obstruction

Indexed keywords

AGAROSE; BONE MORPHOGENETIC PROTEIN 4; CRE RECOMBINASE; GREMLIN; NOGGIN; PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXPLANT; FEMALE; GENE DOSAGE; GENE REPRESSION; GESTATIONAL AGE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TISSUE CULTURE; URETER; URETEROPELVIC JUNCTION; WILD TYPE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CARRIER PROTEINS; FEMALE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY PELVIS; MICE; MUSCLE, SMOOTH; URETER; URETERAL OBSTRUCTION;

EID: 57149106276     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.08.117     Document Type: Article

References (20)

1. Wang Y., Puri P., Hassan J., Miyakita H., and Reen D.J. Abnormal innervation and altered nerve growth factor messenger ribonucleic acid expression in ureteropelvic junction obstruction. J Urol 154 (1995) 679
2. Chang C.P., McDill B.W., Neilson J.R., Joist H.E., Epstein J.A., Crabtree G.R., et al. Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 113 (2004) 1051
3. Mahoney Z.X., Sammut B., Xavier R.J., Cunningham J., Go G., Brim K.L., et al. Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A 103 (2006) 19872
4. Airik R., Bussen M., Singh M.K., Petry M., and Kispert A. Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest 116 (2006) 663
5. Gosling J.A., and Dixon J.S. Functional obstruction of the ureter and renal pelvis. A histological and electron microscopic study. Br J Urol 50 (1978) 145
6. Hanna M.K., Jeffs R.D., Sturgess J.M., and Barkin M. Ureteral structure and ultrastructure: part II. Congenital ureteropelvic junction obstruction and primary obstructive megaureter. J Urol 116 (1976) 725
7. Kajbafzadeh A.M., Payabvash S., Salmasi A.H., Monajemzadeh M., and Tavangar S.M. Smooth muscle cell apoptosis and defective neural development in congenital ureteropelvic junction obstruction. J Urol 176 (2006) 718
8. Murakumo M., Nonomura K., Yamashita T., Ushiki T., Abe K., and Koyanagi T. Structural changes of collagen components and diminution of nerves in congenital ureteropelvic junction obstruction. J Urol 157 (1997) 1963
9. Solari V., Piotrowska A.P., and Puri P. Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction. J Urol 170 (2003) 2420
10. Brenner-Anantharam A., Cebrian C., Guillaume R., Hurtado R., Sun T.T., and Herzlinger D. Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134 (2007) 1967
11. Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233
12. Kulessa H., and Hogan B.L. Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. Genesis 32 (2002) 66
13. Hayashi S., and McMahon A.P. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244 (2002) 305
14. David S.G., Cebrian C., Vaughan E.D., and Herzlinger D. c-Kit and ureteral peristalsis. J Urol 173 (2005) 292
15. Gazzerro E., and Canalis E. Bone morphogentic proteins and their antagonists. Rev Endocr Metab Disord 7 (2006) 51
16. Vainio S., Karavanova I., Jowett A., and Thesleff I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75 (1993) 45
17. Oxburgh L., Chu G.C., Michael S.K., and Robertson E.J. TGF-beta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131 (2004) 4593
18. Foletta V.C., Lim M.A., Soosairajah J., Kelly A.P., Stanley E.G., Shannon M., et al. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol 162 (2003) 1089
19. Hoshino T., Shimizu R., Ohmori S., Nagano M., Pan X., Ohneda O., et al. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells 13 (2008) 159
20. Michos O., Panman L., Vintersten K., Beier K., Zeller R., and Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131 (2004) 3401