The canonical NF-B pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

Oncogene

Volumn 28, Issue 30, 2009, Pages 2710-2722

  Pratt, M A C ^a   Tibbo, E ^a   Robertson, S J ^b   Jansson, D ^a   Hurst, K ^a   Perez Iratxeta, C ^c   Lau, R ^a   Niu, M Y ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Basal; Luminal; Mammary cancer; NF kB; Squamous; Transgenic mice

Indexed keywords

CYTOKERATIN 19; EPIDERMAL GROWTH FACTOR RECEPTOR 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUCIN 1; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ALPHA6 INTEGRIN; CD24 ANTIGEN; ERBB2 PROTEIN, MOUSE; I KAPPA B KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; BREAST CANCER; BREAST CARCINOGENESIS; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; TRANSGENIC MOUSE; ANIMAL; BREAST TUMOR; C57BL MOUSE; CANCER STEM CELL; EXPERIMENTAL NEOPLASM; GENETICS; HUMAN; METABOLISM; MOUSE MAMMARY TUMOR ONCOVIRUS; PHYSIOLOGY;

MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTIGENS, CD24; BREAST NEOPLASMS; HUMANS; I-KAPPA B KINASE; INTEGRIN ALPHA6; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASTIC STEM CELLS; NF-KAPPA B; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 68149164966     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.131     Document Type: Article

References (37)

1. Ackerman A, Viragh PD, Chonchitant N (eds). (1993). Neoplasms with Follicular Differentiation. Lea & Fibiger: Philadelphia.
2. Biswas DK, Dai S-C, Cruz AP, Weiser B, Graner E, Pardee AB. (2001). The nuclear factor κB (NF-κB): a potential therapeutic target for estrogen receptor negative breast cancers. Proc Natl Acad Sci USA 98: 10386-10391.
3. Calza S, Hall P, Auer G, Bjohle J, Kronenwett U, Liu ET et al. (2006). Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients. Breast Cancer Res 8: 4(R34).
4. Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV et al. (2001). IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107: 763-775.
5. Cao Y, Kuo J-l, Karin M. (2007). IκB kinase α kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci USA 104: 15851-15857.
6. Chen D, Xu LG, Chen L, Li L, Zhai Z, Shu HB. (2003). NIK is a component of the EGF/heregulin receptor signalling complexes. Oncogene 22: 4348-4355.
7. Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS. (2000). Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB/p52 and for Bcl-3. Oncogene 19: 1123-1131.
8. Demicco EG, Kavanagh KT, Romieu-Mourez R, Wang X, Shin SR, Landesman-Bollag E et al. (2005). RelB/p52 NF-κB complexes rescue an early delay in mammary gland development in transgenic mice with targeted super repressor IκB-α expression and promote carcinogenesis of the mammary gland. Mol Cell Biol 25: 10136-10147.
9. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ. (2003). In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270.
10. Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V et al. (2007). Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res 27: 547-555.
11. Guy CT, Cardiff RD, Muller WJ. (1992). Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12: 954-961.
12. Habib AA, Chatterjee S, Park S-K, Ratan RR, Lefebvre S, Vartanian T. (2001). The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-κB (NF-κB)-inducing kinase to activate NF-κB. J Biol Chem 276: 8865-8874.
13. Hayden MS, Ghosh S. (2004). Signaling to NF-κB. Genes Dev 18: 2195-2224.
14. Hu MC-T, Lee D-F, Xia W, Golfman LS, Ou-Yang F, Wnag J-Y et al. (2004). IkB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225-237.
15. Huang W-C, Ju T-K, Hung M-C, Chen C.-C. (2007). Phosphorylation of CBP by IKKa promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Mol Cell 26: 75-87.
16. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW et al. (1998). NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 101: 802-811.
17. Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE et al. (2007). Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 12: 160-170.
18. Karin M. (1999). The beginning of the end: IκB kinase (IKK) and NF-κB activation. J Biol Chem 274: 27339-27342.
19. Kim DW, Sovak MA, Zanieski G, Nonet G, Romieu-Mourez R, Lau AW et al. (2000). Activation of NF-κB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21: 871-879.
20. Kordon EC, Smith GH. (1998). An entire functional mammary gland may comprise the progeny from a single cell. Development 125: 1921-1930.
21. Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X et al. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induced mammary cancers from progenitor cells. Proc Natl Acad Sci USA 100: 15853-15858.
22. Livasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT et al. (2006). Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Modem Pathol 19: 264-271.
23. Magness ST, Jijon H, Van Houten-Fisher N, Sharpness NE, Brenner DA, Jobin C. (2004). in vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhances GFP reporter gene mouse. J Immunol 173: 1361-1370.
24. Miyoshi K, Rosner A, Nozawa M, Wang X, Shin SR, Landesman-Bollag E et al. (2001). Activation of different Wnt/b-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors. Oncogene 21: 5548-5556.
25. Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ, Sledge GW. (1997). Constitutive activation of NFκB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17: 3629-3639.
26. Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ, Sonenshein GE. (2001). Her-2/neu overexpression induces NF-κB via a PI-3kinase/AKT pathway involving calpain-mediated degradation of IκBα that can be inhibited by the tumor suppressor PTEN. Oncogene 20: 1287-1299.
27. Pratt MAC, Bishop TE, White D, Yasvinski G, Menard M, Niu MY et al. (2003). Estrogen withdrawal-induced NF-κB activity and Bcl-3 expression in breast cancer cells: Roles in growth and hormoneindependence. Mol Cell Biol 23: 6887-6900.
28. Romieu-Mourez R, Kim DW, Shin SM, Demicco EG, Landesman-Bollag E, Seldin DC et al. (2003). Mouse mammary tumor virus crel transgenic mice develop mammary tumors. Mol Cell Biol 23: 5738-5754.
29. Singh S, Shi Q, Bailey ST, Palczewski MJ, Pardee AB, Inglehart JD et al. (2007). Nuclear factor-kappa B activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. Mol Cancer Ther 6: 1973-1982.
30. Soldani C, Scovassi AI. (2002). Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7: 321-328.
31. Stingl J, Caldas C. (2007). Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nature Rev Cancer 7: 791-798.
32. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D et al. (2006). Puri.cation and unique properties of mammary epithelial cells. Nature 439: 993-997.
33. Tse GM, Tan P-H, Chaiwun B, Putti TC, Lui PCW, Tsang AKH et al. (2006). p63 is useful in the diagnosis of mammary metaplastic carcinomas. Pathology 38: 16-20.
34. Wagner KU, McAllister K, Ward T, Davis B, Wisemen R, Hennighausen L. (2001). Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10: 545-553.
35. Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F et al. (2007). Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target Bcl-2. Nat. Cell Biol 9: 470-478.
36. Wirapati P, Sotirou C, Kunkel S, Farmer P, Pradervand S, Haibe-Kains B et al. (2008). Meta-analysis of gene expression profiles inbreast cancer: toward a uni.ed understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 10: 4 (R65).
37. Zhou Y, Eppenberger-Castori S, Eppenberger U, Benz CC. (2005). The NF-κB pathway and endocrine-resistant breast cancer. Endorine-Related Cancer 12(Suppl 1): S37-S46.