Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase: Importance of a V-shaped dimeric structure for binding to protein substrate

FEBS Journal

Volumn 276, Issue 15, 2009, Pages 4091-4101

  Budiman, Cahyo ^a   Bando, Keisuke ^a   Angkawidjaja, Clement ^a   Koga, Yuichi ^a   Takano, Kazufumi ^a,b   Kanaya, Shigenori ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

FKBP22; Homodimer; Peptidyl prolyl cis trans isomerase (PPIase); Protein engineering; Substrate binding

Indexed keywords

ALPHA LACTALBUMIN; CHIMERIC PROTEIN; DIMER; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 22; OLIGOMER; PEPTIDYLPROLYL ISOMERASE; POLYHISTIDINE TAG; UNCLASSIFIED DRUG; WT1 PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENATURATION; DIFFERENTIAL SCANNING CALORIMETRY; GEL FILTRATION CHROMATOGRAPHY; MUTANT; PRIORITY JOURNAL; PROTEIN BINDING; SHEWANELLA; THERMODYNAMICS; ULTRACENTRIFUGATION; WILD TYPE;

BACTERIAL PROTEINS; CIRCULAR DICHROISM; DIMERIZATION; KINETICS; MODELS, MOLECULAR; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; SHEWANELLA; SUBSTRATE SPECIFICITY; TACROLIMUS BINDING PROTEINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SHEWANELLA SP.;

EID: 68149148640     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07116.x     Document Type: Article

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