High enzymatic activity and chaperone function are mechanistically related features of the dimeric E. coli peptidyl-prolyl-isomerase FkpA

Journal of Molecular Biology

Volumn 310, Issue 2, 2001, Pages 485-498

  Ramm, Kathrin ^a   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Aggregation; Chaperone; FKPB; Peptidyl prolyl cis trans isomerase; Protein folding

Indexed keywords

ASCOMYCIN; CHAPERONE; CITRATE SYNTHASE; CYCLOPHILIN; FK 506 BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CATALYSIS; CYTOPLASM; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ESCHERICHIA COLI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION;

ESCHERICHIA COLI;

EID: 0035816225     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4747     Document Type: Article

References (49)

1. Supervising the fold: Functional principles of molecular chaperones
2. The bonds that tie: Catalyzed disulfide bond formation
3. Structural and evolutionary relationships among the immunophilins: Two ubiquitous families of peptidyl-prolyl cis-trans isomerases
4. Peptidylproline cis/trans isomerases
5. Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts
6. All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae
7. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
8. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
9. Structure of FK506: A novel immunosuppressant isolated from Streptomyces
10. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics
11. FR65814, a novel immunosuppressant isolated from a Penicillium strain. Taxonomy, fermentation, isolation, physico-chemical and biological characteristics and structure assignment
12. Immunophilins in protein folding and immunosuppression
13. Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins
14. A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection
15. The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. II. Isomerase-independent chaperone activity in vitro
16. A ribosome-associated peptidyl-prolyl cis/trans isomerase identified as the trigger factor
17. Chaperone function of Hsp90-associated proteins
18. New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA
19. A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates
20. Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae
21. Program DYNAFIT for the analysis of enzyme kinetic data: Application to HIV proteinase
22. 1. 1. Existence of multiple unfolded states created by proline isomerization
23. 1. 2. Kinetic models for the folding and unfolding reactions
24. 1 in the absence of the disulfide bonds
25. 1 by a stopped-flow double-mixing technique
26. Cooperation of enzymatic and chaperone functions of trigger factor in the catalysis of protein folding
27. Chaperone function of FkpA, a heat shock prolyl isomerase, in the periplasm of Escherichia coli
28. 1
29. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin
30. Conformational specificity of the chaperonin GroEL for the compact folding intermediates of alpha-lactalbumin
31. The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. I. Increased functional expression of antibody fragments with and without cis-prolines
32. Analysis of chaperone function using citrate synthase as non-native substrate protein
33. Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo
34. Whole-genome random sequencing and assembly of Haemophilus influenzae
35. Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl- prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria
36. A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerase FKBP25mem from Legionella pneumophila
37. Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: Evidence for the existence of a family of distinct enzymes
38. A ligand-reversible dimerization system for controlling protein-protein interactions
39. Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli
40. SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins
41. Chaperone activity of DsbC
42. DsbG, a protein disulfide isomerase with chaperone activity
43. Removal of the conserved disulfide bridges from the scFv fragment of an antibody: Effects on folding kinetics and aggregation
44. Expressing antibodies in Escherichia coli
45. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system
46. Calculation of protein extinction coefficients from amino acid sequence data
47. Purification of native proteins from the cytoplasm and periplasm of Escherichia coli using IMAC and histidine tails: A comparison of proteins and protocols
48. Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting
49. Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay