Proteasome inhibition promotes functional recovery after peripheral nerve reperfusion injury

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 3, 2009, Pages 743-748

  Park, Jong Woong ^a,c   Kim, Kwang Mo ^b   Oh, Kwang Joon ^b   Rhyu, Im Joo ^a   Jang, Hyon Seok ^a  

^a Korea University College of Medicine   (South Korea)

^b Keonkook University   (South Korea)

^c Korea University   (South Korea)

Author keywords

Nerve; Proteasome inhibition; Rat; Reperfusion

Indexed keywords

BORTEZOMIB; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATE BUFFERED SALINE; PROTEASOME; BORONIC ACID DERIVATIVE; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; MOTOR PERFORMANCE; MUSCLE CONTRACTION; MUSCLE MASS; NERVE FIBER DEGENERATION; NERVE FIBER REGENERATION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SCIATIC NERVE; WALKING; ANIMAL; DRUG ANTAGONISM; INNERVATION; INTRAVENOUS DRUG ADMINISTRATION; LOCOMOTION; MUSCLE ATROPHY; MUSCLE ISOMETRIC CONTRACTION; NERVE COMPRESSION; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREMEDICATION; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION; VASCULARIZATION;

ANIMALS; BORONIC ACIDS; FEMALE; INJECTIONS, INTRAVENOUS; ISOMETRIC CONTRACTION; LOCOMOTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NERVE COMPRESSION SYNDROMES; PREMEDICATION; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETROGRADE DEGENERATION; SCIATIC NERVE; SYNAPTIC TRANSMISSION;

EID: 68149138149     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181941218     Document Type: Article

References (44)

1. Ichikawa H, Flores S, Kvietys PR, et al. Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. Circ Res. 1997;81:922-931.
2. Yoshida N, Granger DN, Anderson DC, et al. Anoxia/reoxygenationinduced neutrophil adherence to cultured endothelial cells. Am J Physiol. 1992;262(6 Pt 2):H1891-H1898.
3. Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem. 1994;63:175-195.
4. Sayan H, Ugurlu B, Babul A, et al. Effects of L-arginine and NGnitro L-arginine methyl ester on lipid peroxide, superoxide dismutase and nitrate levels after experimental sciatic nerve ischemiareperfusion in rats. Int J Neurosci. 2004;114:349-364.
5. Qi WN, Chen LE, Seaber AV, et al. Regulation of NOS mRNA expression in reperfused muscle. Microsurgery. 1999;19:18-19.
6. Qi WN, Yan ZQ, Whang PG, et al. Gene and protein expressions of nitric oxide synthases in ischemia-reperfused peripheral nerve of the rat. Am J Physiol Cell Physiol. 2001;281:C849-C856.
7. Zhang L, Looney CG, Qi WN, et al. Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. J Appl Physiol. 2003;94:1473-1478.
8. Ioculano M, Squadrito F, Altavilla D, et al. Antibodies against intercellular adhesion molecule 1 protect against myocardial ischaemia-reperfusion injury in rat. Eur J Pharmacol. 1994; 264:143-149.
9. Howard EF, Chen Q, Cheng C, et al. NF-kappa B is activated and ICAM-1 gene expression is upregulated during reoxygenation of human brain endothelial cells. Neurosci Lett. 1998;248:199-203.
10. Berti R, Williams AJ, Moffett JR, et al. Quantitative real-time RTPCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury. J Cereb Blood Flow Metab. 2002; 22:1068-1079.
11. Jerome SN, Dore M, Paulson JC, et al. P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of postischemic no-reflow. Am J Physiol. 1994;266(4 Pt 2):H1316-H1321.
12. Lenardo MJ, Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell. 1989;58:227-229.
13. Pritts TA, Moon MR, Wang Q, et al. Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia. Shock. 2000;14:118-122.
14. Pye J, Ardeshirpour F, McCain A, et al. Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury. Am J Physiol Heart Circ Physiol. 2003; 284:H919-H926.
15. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002;109 (Suppl):S81-S96.
16. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol. 2000;18:621-663.
17. Roff M, Thompson J, Rodriguez MS, et al. Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo. J Biol Chem. 1996;271:7844-7850.
18. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem. 1994;269:4705-4708.
19. Nathan C. Inducible nitric oxide synthase: regulation subserves function. Curr Top Microbiol Immunol. 1995;196:1-4.
20. Goldring CE, Narayanan R, Lagadec P, et al. Transcriptional inhibition of the inducible nitric oxide synthase gene by competitive binding of NF-kappa B/Rel proteins. Biochem Biophys Res Commun. 1995;209:73-79.
21. Altavilla D, Deodato B, Campo GM, et al. IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factorkappaB and reduces the inflammatory response in myocardial ischemia-reperfusion injury. Cardiovasc Res. 2000;47:515-528.
22. Bao J, Sato K, Li M, et al. PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation. Am J Physiol Heart Circ Physiol. 2001; 281:H2612-H2618.
23. Adams J. The proteasome: structure, function, and role in the cell. Cancer Treat Rev. 2003;29 (Suppl 1):3-9.
24. Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg. 1989;83:129-138.
25. Chen LE, Seaber AV, Glisson RR, et al. The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res. 1992;10:657-664.
26. Chen LE, Seaber AV, Urbaniak JR. The influence of magnitude and duration of crush load on functional recovery of the peripheral nerve. J Reconstr Microsurg. 1993;9:299 -306; discussion 306-297.
27. Spink J, Cohen J, Evans TJ. The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase. Activation by nuclear factor-kappa B. J Biol Chem. 1995; 270:29541-29547.
28. Fan H, Sun B, Gu Q, et al. Oxygen radicals trigger activation of NFkappaB and AP-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol Heart Circ Physiol. 2002;282:H1778-H1786.
29. Phillips JB, Williams AJ, Adams J, et al. Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia. Stroke. 2000;31:1686-1693.
30. Chandrasekar B, Smith JB, Freeman GL. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation. 2001;103:2296-2302.
31. Chandrasekar B, Streitman JE, Colston JT, et al. Inhibition of nuclear factor kappa B attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium. Biochim Biophys Acta. 1998;1406:91-106.
32. Parrino PE, Laubach VE, Gaughen JR Jr, et al. Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow. Ann Thorac Surg. 1998;66:733-739.
33. Patel P, Qi WN, Allen DM, et al. Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. Microsurgery. 2004; 24:324-331.
34. Park JW, Qi WN, Cai Y, et al. The effects of exogenous nitric oxide donor on motor functional recovery of reperfused peripheral nerve. J Hand Surg [Am]. 2005;30:519-527.
35. Park JW, Qi WN, Liu JQ, et al. Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. Microsurgery. 2005;25:606-613.
36. Vagnerova K, Hurn PD, Bhardwaj A, et al. Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase. Anesth Analg. 2006;103:430-434; table of contents.
37. Qi WN, Chaiyakit P, Cai Y, et al. NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. Microsurgery. 2004;24:316-323.
38. de Vera ME, Shapiro RA, Nussler AK, et al. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci USA. 1996;93:1054-1059.
39. Fan H, Sun B, Gu Q, et al. Oxygen radicals trigger activation of NF-kappaB and AP-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol Heart Circ Physiol. 2002;282:H1778-H1786.
40. Zou L, Attuwaybi B, Kone BC. Effects of NF-kappa B inhibition on mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2003;284:G713-G721.
41. Williams AJ, Hale SL, Moffett JR, et al. Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappaB activation, gliosis, and leukocyte infiltration. J Cereb Blood Flow Metab. 2003;23:75-87.
42. Campbell B, Adams J, Shin YK, et al. Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart. J Mol Cell Cardiol. 1999;31:467- 476.
43. Smith KJ, Kapoor R, Felts PA. Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathol. 1999;9:69-92.
44. Bongarzone ER, Soto EF, Pasquini JM. Increased susceptibility to degradation by trypsin and subtilisin of in vitro peroxidized myelin proteins. Neurochem Res. 1995;20:421-426.