메뉴 건너뛰기




Volumn 8, Issue 9, 2009, Pages 820-822

Piling up the JNK: Drug synergy through ER stress

Author keywords

Antagonist; Apoptosis; Bcl 2; Caspase 4; eIF2 ; Endoplasmic reticulum; HA14 1; JNK; PERK; Proteasome inhibitor

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; BORTEZOMIB; DEXAMETHASONE; DOXORUBICIN; FLAVOPIRIDOL; REACTIVE OXYGEN METABOLITE; SALINOSPORAMIDE A; STRESS ACTIVATED PROTEIN KINASE;

EID: 68149099778     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.9.8403     Document Type: Note
Times cited : (1)

References (26)
  • 1
    • 20044396543 scopus 로고    scopus 로고
    • Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 2005; 23:667-75.
    • (2005) J Clin Oncol , vol.23 , pp. 667-675
    • Goy, A.1    Younes, A.2    McLaughlin, P.3    Pro, B.4    Romaguera, J.E.5    Hagemeister, F.6
  • 3
    • 34548409572 scopus 로고    scopus 로고
    • Clinical impact of bortezomib in frontline regimens for patients with multiple myeloma
    • Manochankian R, Miller K, Chanan-Khan A. Clinical impact of bortezomib in frontline regimens for patients with multiple myeloma. Oncologist 2007; 12:978-90.
    • (2007) Oncologist , vol.12 , pp. 978-990
    • Manochankian, R.1    Miller, K.2    Chanan-Khan, A.3
  • 4
    • 61849128387 scopus 로고    scopus 로고
    • Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survival compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre phase 2 clinical trial
    • O'Connor OA, Moskowitz C, Portlock C, Hamlin P, Straus D, Dumitrescu O, et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survival compared with patients with relapsed disease following treatment with single agent bortezomib: results of a multicentre phase 2 clinical trial. Br J Haematol 2009; 145:34-9.
    • (2009) Br J Haematol , vol.145 , pp. 34-39
    • O'Connor, O.A.1    Moskowitz, C.2    Portlock, C.3    Hamlin, P.4    Straus, D.5    Dumitrescu, O.6
  • 5
    • 0038649638 scopus 로고    scopus 로고
    • The proteasome-an emerging therapeutic target in cancer
    • Mitchell BS. The proteasome-an emerging therapeutic target in cancer. N Engl J Med 2003; 348:2597-8.
    • (2003) N Engl J Med , vol.348 , pp. 2597-2598
    • Mitchell, B.S.1
  • 6
    • 33645737411 scopus 로고    scopus 로고
    • Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in cancer cells
    • Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Andtbacka RH, Dunner K Jr, et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in cancer cells. Cancer Res 2006; 66:3773-81.
    • (2006) Cancer Res , vol.66 , pp. 3773-3781
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3    Highshaw, R.A.4    Andtbacka, R.H.5    Dunner Jr, K.6
  • 7
    • 26844570219 scopus 로고    scopus 로고
    • Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy
    • Linder S, Shoshan MC. Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy. Drug Resist Updat 2005; 8:199-204.
    • (2005) Drug Resist Updat , vol.8 , pp. 199-204
    • Linder, S.1    Shoshan, M.C.2
  • 8
    • 56449087512 scopus 로고    scopus 로고
    • Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways
    • Fels DR, Ye J, Segan A, Kridel S, Spiotto M, Olson M, et al. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res 2008; 68:9323-30.
    • (2008) Cancer Res , vol.68 , pp. 9323-9330
    • Fels, D.R.1    Ye, J.2    Segan, A.3    Kridel, S.4    Spiotto, M.5    Olson, M.6
  • 10
    • 33751189389 scopus 로고    scopus 로고
    • Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress
    • Fribley A, Wang C. Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress. Cancer Biol Ther 2006; 5:808-19.
    • (2006) Cancer Biol Ther , vol.5 , pp. 808-819
    • Fribley, A.1    Wang, C.2
  • 11
    • 33847714599 scopus 로고    scopus 로고
    • Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
    • Meister S, Schubert U, Neubert K, Herrmann K, Burger R, Gramatzki M, et al. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res 2007; 67:1783-92.
    • (2007) Cancer Res , vol.67 , pp. 1783-1792
    • Meister, S.1    Schubert, U.2    Neubert, K.3    Herrmann, K.4    Burger, R.5    Gramatzki, M.6
  • 12
    • 38949125853 scopus 로고    scopus 로고
    • Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh A, Brahmandam M, Podar K, Hideshim T, Richardson P, et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008; 111:1654-64.
    • (2008) Blood , vol.111 , pp. 1654-1664
    • Chauhan, D.1    Singh, A.2    Brahmandam, M.3    Podar, K.4    Hideshim, T.5    Richardson, P.6
  • 13
    • 33750209537 scopus 로고    scopus 로고
    • A novel proteasome inhibitor NPI-0052 as an anti-cancer therapy
    • Chauhan D, Hideshim T, Anderson KC. A novel proteasome inhibitor NPI-0052 as an anti-cancer therapy. Br J Cancer 2006; 95:961-5.
    • (2006) Br J Cancer , vol.95 , pp. 961-965
    • Chauhan, D.1    Hideshim, T.2    Anderson, K.C.3
  • 14
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    • Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000; 97:7124-9.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7124-7129
    • Wang, J.L.1    Liu, D.2    Zhang, Z.J.3    Shan, S.4    Han, X.5    Srinivasula, S.M.6
  • 15
    • 52949151912 scopus 로고    scopus 로고
    • Bcl-2 family members as molecular targets in cancer therapy
    • Marzo I, Naval J. Bcl-2 family members as molecular targets in cancer therapy. Biochem Pharmacol 2008; 76:939-46.
    • (2008) Biochem Pharmacol , vol.76 , pp. 939-946
    • Marzo, I.1    Naval, J.2
  • 16
    • 41849083758 scopus 로고    scopus 로고
    • Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: A potential therapeutic approach to EBV-associated lymphoproliferative diseases
    • Srimatkandada P, Loomis R, Carbone R, Srimatkandada S, Lacy J. Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: a potential therapeutic approach to EBV-associated lymphoproliferative diseases. Eur J Haematol 2008; 80:407-18.
    • (2008) Eur J Haematol , vol.80 , pp. 407-418
    • Srimatkandada, P.1    Loomis, R.2    Carbone, R.3    Srimatkandada, S.4    Lacy, J.5
  • 19
    • 0142244338 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells
    • Pei XY, Dai Y, Grant S. The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. Leukemia 2003; 17:2036-45.
    • (2003) Leukemia , vol.17 , pp. 2036-2045
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 20
    • 0032080328 scopus 로고    scopus 로고
    • High constitutive NFkappaB activity mediates resistance to oxidative stress in neuronal cells
    • Lezoualc'h F, Sagara Y, Holsboer F, Behl C. High constitutive NFkappaB activity mediates resistance to oxidative stress in neuronal cells. J Neurosci 1998; 18:3224-32.
    • (1998) J Neurosci , vol.18 , pp. 3224-3232
    • Lezoualc'h, F.1    Sagara, Y.2    Holsboer, F.3    Behl, C.4
  • 22
    • 37549018038 scopus 로고    scopus 로고
    • Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2- oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis
    • Doshi J, Tian D, Xing C. Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2- oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. Mol Pharm 2007; 4:919-28.
    • (2007) Mol Pharm , vol.4 , pp. 919-928
    • Doshi, J.1    Tian, D.2    Xing, C.3
  • 23
    • 68149149793 scopus 로고    scopus 로고
    • Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress
    • Dasmahapatra G, Lembersky D, Rahmani M, Kramer L, Friedberg J, Fisher RI, et al. Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. Cancer Biol Ther 2009; 8:721-32.
    • (2009) Cancer Biol Ther , vol.8 , pp. 721-732
    • Dasmahapatra, G.1    Lembersky, D.2    Rahmani, M.3    Kramer, L.4    Friedberg, J.5    Fisher, R.I.6
  • 24
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8:519-29.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 25
    • 58749113252 scopus 로고    scopus 로고
    • Chemotherapeutic sensitization by endoplasmic reticulum stress: Increasing the efficacy of taxane against prostate cancer
    • Wu Y, Fabritius M, Ip C. Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer. Cancer Biol Ther 2009; 8:146-52.
    • (2009) Cancer Biol Ther , vol.8 , pp. 146-152
    • Wu, Y.1    Fabritius, M.2    Ip, C.3
  • 26
    • 53549119055 scopus 로고    scopus 로고
    • Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
    • Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, et al. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther 2008; 7:1648-62.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1648-1662
    • Park, M.A.1    Zhang, G.2    Martin, A.P.3    Hamed, H.4    Mitchell, C.5    Hylemon, P.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.