-
1
-
-
20044396543
-
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
-
Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, et al. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 2005; 23:667-75.
-
(2005)
J Clin Oncol
, vol.23
, pp. 667-675
-
-
Goy, A.1
Younes, A.2
McLaughlin, P.3
Pro, B.4
Romaguera, J.E.5
Hagemeister, F.6
-
2
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005; 352:2487-98.
-
(2005)
N Engl J Med
, vol.352
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
-
3
-
-
34548409572
-
Clinical impact of bortezomib in frontline regimens for patients with multiple myeloma
-
Manochankian R, Miller K, Chanan-Khan A. Clinical impact of bortezomib in frontline regimens for patients with multiple myeloma. Oncologist 2007; 12:978-90.
-
(2007)
Oncologist
, vol.12
, pp. 978-990
-
-
Manochankian, R.1
Miller, K.2
Chanan-Khan, A.3
-
4
-
-
61849128387
-
Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survival compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre phase 2 clinical trial
-
O'Connor OA, Moskowitz C, Portlock C, Hamlin P, Straus D, Dumitrescu O, et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survival compared with patients with relapsed disease following treatment with single agent bortezomib: results of a multicentre phase 2 clinical trial. Br J Haematol 2009; 145:34-9.
-
(2009)
Br J Haematol
, vol.145
, pp. 34-39
-
-
O'Connor, O.A.1
Moskowitz, C.2
Portlock, C.3
Hamlin, P.4
Straus, D.5
Dumitrescu, O.6
-
5
-
-
0038649638
-
The proteasome-an emerging therapeutic target in cancer
-
Mitchell BS. The proteasome-an emerging therapeutic target in cancer. N Engl J Med 2003; 348:2597-8.
-
(2003)
N Engl J Med
, vol.348
, pp. 2597-2598
-
-
Mitchell, B.S.1
-
6
-
-
33645737411
-
Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in cancer cells
-
Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Andtbacka RH, Dunner K Jr, et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in cancer cells. Cancer Res 2006; 66:3773-81.
-
(2006)
Cancer Res
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner Jr, K.6
-
7
-
-
26844570219
-
Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy
-
Linder S, Shoshan MC. Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy. Drug Resist Updat 2005; 8:199-204.
-
(2005)
Drug Resist Updat
, vol.8
, pp. 199-204
-
-
Linder, S.1
Shoshan, M.C.2
-
8
-
-
56449087512
-
Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways
-
Fels DR, Ye J, Segan A, Kridel S, Spiotto M, Olson M, et al. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res 2008; 68:9323-30.
-
(2008)
Cancer Res
, vol.68
, pp. 9323-9330
-
-
Fels, D.R.1
Ye, J.2
Segan, A.3
Kridel, S.4
Spiotto, M.5
Olson, M.6
-
10
-
-
33751189389
-
Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress
-
Fribley A, Wang C. Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress. Cancer Biol Ther 2006; 5:808-19.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 808-819
-
-
Fribley, A.1
Wang, C.2
-
11
-
-
33847714599
-
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
-
Meister S, Schubert U, Neubert K, Herrmann K, Burger R, Gramatzki M, et al. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res 2007; 67:1783-92.
-
(2007)
Cancer Res
, vol.67
, pp. 1783-1792
-
-
Meister, S.1
Schubert, U.2
Neubert, K.3
Herrmann, K.4
Burger, R.5
Gramatzki, M.6
-
12
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan D, Singh A, Brahmandam M, Podar K, Hideshim T, Richardson P, et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008; 111:1654-64.
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
Podar, K.4
Hideshim, T.5
Richardson, P.6
-
13
-
-
33750209537
-
A novel proteasome inhibitor NPI-0052 as an anti-cancer therapy
-
Chauhan D, Hideshim T, Anderson KC. A novel proteasome inhibitor NPI-0052 as an anti-cancer therapy. Br J Cancer 2006; 95:961-5.
-
(2006)
Br J Cancer
, vol.95
, pp. 961-965
-
-
Chauhan, D.1
Hideshim, T.2
Anderson, K.C.3
-
14
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, Liu D, Zhang ZJ, Shan S, Han X, Srinivasula SM, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000; 97:7124-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
Shan, S.4
Han, X.5
Srinivasula, S.M.6
-
15
-
-
52949151912
-
Bcl-2 family members as molecular targets in cancer therapy
-
Marzo I, Naval J. Bcl-2 family members as molecular targets in cancer therapy. Biochem Pharmacol 2008; 76:939-46.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 939-946
-
-
Marzo, I.1
Naval, J.2
-
16
-
-
41849083758
-
Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: A potential therapeutic approach to EBV-associated lymphoproliferative diseases
-
Srimatkandada P, Loomis R, Carbone R, Srimatkandada S, Lacy J. Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: a potential therapeutic approach to EBV-associated lymphoproliferative diseases. Eur J Haematol 2008; 80:407-18.
-
(2008)
Eur J Haematol
, vol.80
, pp. 407-418
-
-
Srimatkandada, P.1
Loomis, R.2
Carbone, R.3
Srimatkandada, S.4
Lacy, J.5
-
17
-
-
33646003521
-
Bortezomib interactions with chemotherapy agents in acute leukemia in vitro
-
Horton TM, Gannavarpu A, Blaney S, D'Argenio D, Plon S, Berg S. Bortezomib interactions with chemotherapy agents in acute leukemia in vitro. Cancer Chemother Pharmacol 2006; 58:13-23.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 13-23
-
-
Horton, T.M.1
Gannavarpu, A.2
Blaney, S.3
D'Argenio, D.4
Plon, S.5
Berg, S.6
-
18
-
-
0035211881
-
Novel therapies targeting the myeloma cell and its bone marrow microenvironment
-
Hideshima T, Chauhan D, Podar K, Schlossman RL, Richardson P, Anderson KC. Novel therapies targeting the myeloma cell and its bone marrow microenvironment. Semin Oncol 2001; 28:607-12.
-
(2001)
Semin Oncol
, vol.28
, pp. 607-612
-
-
Hideshima, T.1
Chauhan, D.2
Podar, K.3
Schlossman, R.L.4
Richardson, P.5
Anderson, K.C.6
-
19
-
-
0142244338
-
The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells
-
Pei XY, Dai Y, Grant S. The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells. Leukemia 2003; 17:2036-45.
-
(2003)
Leukemia
, vol.17
, pp. 2036-2045
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
20
-
-
0032080328
-
High constitutive NFkappaB activity mediates resistance to oxidative stress in neuronal cells
-
Lezoualc'h F, Sagara Y, Holsboer F, Behl C. High constitutive NFkappaB activity mediates resistance to oxidative stress in neuronal cells. J Neurosci 1998; 18:3224-32.
-
(1998)
J Neurosci
, vol.18
, pp. 3224-3232
-
-
Lezoualc'h, F.1
Sagara, Y.2
Holsboer, F.3
Behl, C.4
-
21
-
-
18544367201
-
NFkappaB as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, et al. NFkappaB as a therapeutic target in multiple myeloma. J Biol Chem 2002; 277:16639-47.
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
-
22
-
-
37549018038
-
Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2- oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis
-
Doshi J, Tian D, Xing C. Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2- oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis. Mol Pharm 2007; 4:919-28.
-
(2007)
Mol Pharm
, vol.4
, pp. 919-928
-
-
Doshi, J.1
Tian, D.2
Xing, C.3
-
23
-
-
68149149793
-
Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress
-
Dasmahapatra G, Lembersky D, Rahmani M, Kramer L, Friedberg J, Fisher RI, et al. Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. Cancer Biol Ther 2009; 8:721-32.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 721-732
-
-
Dasmahapatra, G.1
Lembersky, D.2
Rahmani, M.3
Kramer, L.4
Friedberg, J.5
Fisher, R.I.6
-
24
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8:519-29.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
25
-
-
58749113252
-
Chemotherapeutic sensitization by endoplasmic reticulum stress: Increasing the efficacy of taxane against prostate cancer
-
Wu Y, Fabritius M, Ip C. Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer. Cancer Biol Ther 2009; 8:146-52.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 146-152
-
-
Wu, Y.1
Fabritius, M.2
Ip, C.3
-
26
-
-
53549119055
-
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
-
Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, et al. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther 2008; 7:1648-62.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1648-1662
-
-
Park, M.A.1
Zhang, G.2
Martin, A.P.3
Hamed, H.4
Mitchell, C.5
Hylemon, P.B.6
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