Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Rivera, José ^a   Megías, Diego ^a   Navas, Carolina ^a   Bravo, Jerónimo ^a,b  

^a Structural Biology and Biocomputing Programme   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER METASTASIS SUPPRESSOR 1; KARYOPHERIN ALPHA; KARYOPHERIN ALPHA1; KARYOPHERIN ALPHA3; KARYOPHERIN ALPHA6; LEPTOMYCIN B; ONCOPROTEIN; UNCLASSIFIED DRUG; BRMS1 PROTEIN, MOUSE; KARYOPHERIN; REPRESSOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HETEROKARYON; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SEQUENCE ANALYSIS; ANIMAL; GENETICS; METABOLISM; METASTASIS; MOLECULAR GENETICS; NUCLEAR LOCALIZATION SIGNAL; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; GENES, TUMOR SUPPRESSOR; HUMANS; KARYOPHERINS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; NUCLEAR LOCALIZATION SIGNALS; PROTEIN TRANSPORT; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 68149097080     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006433     Document Type: Article

References (44)

1. Rinker-Schaeffer CW, O'Keefe JP, Welch DR, Theodorescu D (2006) Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application. Clin Cancer Res 12: 3882-3889.
2. Saunders MM, Seraj MJ, Li Z, Zhou Z, Winter CR, et al. (2001) Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res 61: 1765-1767.
3. Hurst DR,Xie Y, Vaidya KS, Mehta A, Moore BP, et al. (2008) Alterations of breast cancer metastasis suppressor 1:At rich interactive domain 4A interaction modify gene expression but still suppress metastasis in human breast cancer cells. J Biol Chem.
4. Liu Y, Smith PW, Jones DR (2006) Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. Mol Cell Biol 26: 8683-8696.
5. Meehan WJ, Samant RS, Hopper JE, Carrozza MJ, Shevde LA, et al. (2004) Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem 279: 1562-1569.
6. DeWald DB, Torabinejad J, Samant RS, Johnston D, Erin N, et al. (2005) Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells. Cancer Res 65: 713-717.
7. Cicek M, Fukuyama R, Welch DR, Sizemore N, Casey G (2005) Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity. Cancer Res 65: 3586-3595.
8. Rivera J, Megias D, Bravo J (2007) Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1. J Proteome Res 6: 4006-4018.
9. Samant RS, Clark DW, Fillmore RA, Cicek M, Metge BJ, et al. (2007) Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation. Mol Cancer 6: 6.
10. Yang J, Zhang B, Lin Y, Yang Y, Liu X, et al. (2008) Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression. Cancer Lett 269: 46-56.
11. Hurst DR, Mehta A, Moore BP, Phadke PA, Meehan WJ, et al. (2006) Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun 348: 1429-1435.
12. Terry LJ, Shows EB, Wente SR (2007) Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science 318: 1412-1416.
13. Kuersten S, Ohno M, Mattaj IW (2001) Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol 11: 497-503.
14. Fornerod M, Ohno M, Yoshida M, Mattaj IW (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
15. Kutay U, Guttinger S (2005) Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol 15: 121-124.
16. la Cour T, Kiemer L, Molgaard A, Gupta R, Skriver K, et al. (2004) Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel 17: 527-536.
17. Bogerd HP, Fridell RA, Benson RE, Hua J, Cullen BR (1996) Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol Cell Biol 16: 4207-4214.
18. Nakai K, Horton P (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem Sci 24: 34-36.
19. Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, et al. (2007) Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 282: 5101-5105.
20. Sorg G, Stamminger T (1999) Mapping of nuclear localization signals by simultaneous fusion to green fluorescent protein and to beta-galactosidase. Biotechniques 26: 858-862.
21. Fahrenkrog B, Stoffler D, Aebi U (2001) Nuclear pore complex architecture and functional dynamics. Curr Top Microbiol Immunol 259: 95-117.
22. Lischka P, Sorg G, Kann M, Winkler M, Stamminger T (2003) A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/ beta pathway. J Virol 77: 3734-3748.
23. Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, et al. (1997) Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. FEBS Lett 417: 104-108.
24. Rivera J, Abrams C, Hernaez B, Alcazar A, Escribano JM, et al. (2007) The MyD116 African swine fever virus homologue interacts with the catalytic subunit of protein phosphatase 1 and activates its phosphatase activity. J Virol 81: 2923-2929.
25. Harreman MT, Cohen PE, Hodel MR, Truscott GJ, Corbett AH, et al. (2003) Characterization of the auto-inhibitory sequence within the N-terminal domain of importin alpha. J Biol Chem 278: 21361-21369.
26. Harreman MT, Hodel MR, Fanara P, Hodel AE, Corbett AH (2003) The auto-inhibitory function of importin alpha is essential in vivo. J Biol Chem 278: 5854-5863.
27. Borer RA, Lehner CF, Eppenberger HM, Nigg EA (1989) Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56: 379-390.
28. Schmidt-Zachmann MS, Dargemont C, Kuhn LC, Nigg EA (1993) Nuclear export of proteins: the role of nuclear retention. Cell 74: 493-504.
29. Henderson BR, Eleftheriou A (2000) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Exp Cell Res 256: 213-224.
30. Gorlich D, Mattaj IW (1996) Nucleocytoplasmic transport. Science 271: 1513-1518.
31. Nigg EA (1997) Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386: 779-787.
32. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
33. Wolff B, Cohen G, Hauber J, Meshcheryakova D, Rabeck C (1995) Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein. Exp Cell Res 217: 31-41.
34. Fornerod M, Ohno M (2002) Exportin-mediated nuclear export of proteins and ribonucleoproteins. Results Probl Cell Differ 35: 67-91.
35. Lim J, Hao T, Shaw C, Patel AJ, Szabo G, et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125: 801-814.
36. Sekimoto T, Fukumoto M, Yoneda Y (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). Embo J 23: 1934-1942.
37. Thompson ME, Robinson-Benion CL, Holt JT (2005) An amino-terminal motif functions as a second nuclear export sequence in BRCA1. J Biol Chem 280: 21854-21857.
38. Nilsen T, Rosendal KR, Sorensen V, Wesche J, Olsnes S, et al. (2007) A nuclear export sequence located on a beta-strand in fibroblast growth factor-1. J Biol Chem 282: 26245-26256.
39. Gama-Carvalho M, Carmo-Fonseca M (2001) The rules and roles of nucleocytoplasmic shuttling proteins. FEBS Lett 498: 157-163.
40. Kau TR, Silver PA (2003) Nuclear transport as a target for cell growth. Drug Discov Today 8: 78-85.
41. Fabbro M, Henderson BR (2003) Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Exp Cell Res 282: 59-69.
42. Kau TR, Way JC, Silver PA (2004) Nuclear transport and cancer: from mechanism to intervention. Nat Rev Cancer 4: 106-117.
43. Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 33: 151-152.
44. James P, Halladay J, Craig EA (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.