Combined computational and biochemical study reveals the importance of electrostatic interactions between the "pH sensor" and the cation binding site of the sodium/proton antiporter NhaA of Escherichia coli

Proteins: Structure, Function and Bioinformatics

Volumn 76, Issue 3, 2009, Pages 548-559

  Olkhova, Elena ^a   Kozachkov, Lena ^b   Padan, Etana ^b   Michel, Hartmut ^a  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Conformation; Continuum electrostatics; NhaA Na + H + antiporter; pH dependent activation; Single mutations

Indexed keywords

ANTIPORTER; GLUTAMIC ACID; SODIUM PROTON ANTIPORTER NHAA; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATION TRANSPORT; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRICITY; ESCHERICHIA COLI; MATHEMATICAL COMPUTING; MEMBRANE STRUCTURE; MOLECULAR INTERACTION; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; SODIUM TRANSPORT;

BINDING SITES; CATIONS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SODIUM-HYDROGEN ANTIPORTER; STATIC ELECTRICITY;

ESCHERICHIA COLI;

EID: 68049148763     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22368     Document Type: Article

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