Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat

Cancer Biology and Therapy

Volumn 8, Issue 10, 2009, Pages 899-906

  Sukhotnik, Igor ^a,b   Mogilner, Jorge G ^b   Shteinberg, Dan ^a   Karry, Rahel ^a   Lurie, Michael ^b   Ure, Benno M ^c   Shaoul, Ron ^b   Corane, Arnold G ^d  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Apoptosis; Caco 2 cells; Enterocyte proliferation; Leptin; Methotrexate; Mucositis

Indexed keywords

DNA; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; LEPTIN; MESSENGER RNA; METHOTREXATE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GASTROINTESTINAL MUCOSA; HUMAN; HUMAN CELL; ILEUM; INTESTINE CELL; INTESTINE CRYPT; INTESTINE INJURY; INTESTINE VILLUS; JEJUNUM; MALE; MUCOSA INFLAMMATION; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE;

ANIMALS; ANNEXIN A5; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CACO-2 CELLS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCYTES; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; ILEUM; INTESTINAL MUCOSA; JEJUNUM; LEPTIN; MALE; METHOTREXATE; MUCOSITIS; ORGAN SIZE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RNA, MESSENGER; TIME FACTORS;

EID: 68049137586     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.10.8128     Document Type: Article

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