Allosteric control of gating mechanisms revisited: The large conductance Ca2+-activated K2+ channel

Biophysical Journal

Volumn 96, Issue 10, 2009, Pages 3987-3996

  Rosales, Rafael A ^a   Varanda, Wamberto A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT;

ALLOSTERISM; ARTICLE; BAYES THEOREM; CHANNEL GATING; MEMBRANE POTENTIAL; MONTE CARLO METHOD; STATISTICS; VALIDITY; BIOLOGICAL MODEL; DOSE RESPONSE; METABOLISM; PROBABILITY; REPRODUCIBILITY;

ALLOSTERIC REGULATION; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MARKOV CHAINS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PROBABILITY; REPRODUCIBILITY OF RESULTS;

EID: 68049122042     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.02.042     Document Type: Article

References (28)

1. McManus, O. B., and K. L. Magleby. 1988. Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle. J. Physiol. 402:79-120.
2. McManus, O. B., and K. L. Magleby. 1989. Kinetic time constants independent of previous single-channel activity suggest Markov gating for a large conductance Ca-activated K channel. J. Gen. Physiol. 94:1037-1070.
3. + channels in rat skeletal muscle. J. Physiol. 443:739-777.
4. + channel. J. Gen. Physiol. 110:257-281.
5. + channels. J. Gen. Physiol. 109:647-673.
6. + channels. Biochemistry. 39:15612-15619.
7. 2+. J. Gen. Physiol. 114:277-304.
8. 2+. J. Gen. Physiol. 114:305-336.
9. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:267-305.
10. Monod, J., J. Wyman, and J. P. Changeux. 1965. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12:88-118.
11. Cox, D. H. 2006. BKCa-channel structure and function. In Biological Membrane Ion Channels. S. H. Chung, O. Andersen, and V. Krishnamurty, editors. Springer-Verlag, New York.
12. + channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers. J. Gen. Physiol. 111:751-780.
13. 2+ suggest a two-tiered allosteric gating mechanism. J. Gen. Physiol. 114:93-124.
14. + channels described by a two-tiered allosteric gating mechanism. J. Gen. Physiol. 116:75-99.
15. Rosales, R. A. 2004. MCMC for hidden Markov models incorporating aggregation of states and filtering. Bull. Math. Biol. 66:1173-1199.
16. Chung, S. H., J. B. Moore, L. Xia, L. S. Premkumar, and P. W. Gage. 1990. Characterization of single channel currents using digital signal processing techniques based on hidden Markov Models. Philos. Trans. R. Soc. Lond. B Biol. Sci. 329:265-285.
17. Ventakaramanan, L., and F. J. Sigworth. 2002. Applying hidden Markov models to the analysis of single ion channel activity. Biophys. J. 82:1930-1942.
18. de Gunst, M. C. M., H. R. Künsh, and J. G. Schouten. 2001. Statistical analysis of ion channel data using hidden Markov models with correlated state-dependent noise and filtering. J. Am. Stat. Assoc. 96:805-815.
19. Golub, G. H., and C. F. Van Loan. 1989. Matrix Computations, 2nd Ed. Johns Hopkins University Press, Baltimore, Maryland.
20. Colquhoun, D., and A. G. Hawkes. 1982. On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Phil. Trans. Roy. Soc. Lond. B. 300:1-59.
21. Colquhoun, D., and A. G. Hawkes. 1995. The principles of the stochastic interpretation of ion-channel mechanisms. In Single Channel Recording. B. Sackmann and E. Neher, editors. Plenum Press, New York.
22. Colquhoun, D., and F. J. Sigworth. 1995. Fitting and statistical analysis of single-channel records. In Single Channel Recordings. B. Sackmann and E. Neher, editors. Plenum Press, New York.
23. Magleby, K. L., and L. Song. 1992. Dependency plots suggest the kinetic structure of ion channels. Proc. R. Soc. Lond. B. Biol. Sci. 249:133-142.
24. Rosales, R. A., W. J. Fitzgerald, and S. B. Hladky. 2002. Kernel estimates for one- and two-dimensional ion channel dwell time densities. Biophys. J. 82:29-35.
25. Carnio, E. C., and W. A. Varanda. 1995. Calcium-activated potassium channels are involved in the response of mouse Leydig cells to human chorionic gonadotropin. Braz. J. Med. Biol. Res. 28:813-824.
26. 2+ sensitivity. J. Gen. Physiol. 120:173-189.
27. Xia, X. M., X. Zeng, and C. J. Lingle. 2002. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature. 418:880-884.
28. 2+ binding constants: effects of membrane voltage. J. Gen. Physiol. 132:491-505.