Antihyperglycaemic and antiperoxidative roles of acarbose in type 2 diabetes mellitus are possibly mediated through changes in thyroid function

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 11, 2006, Pages 1104-1106

  Rameshwar, Jatwa ^a   Anand, Kar ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

Acarbose; Dexamethasone; Lipid peroxidation; Thyroid hormones; Type 2 diabetes mellitus

Indexed keywords

ACARBOSE; ANTIOXIDANT; CATALASE; DEXAMETHASONE; GLUCOSE; GLUTATHIONE; INSULIN; SUPEROXIDE DISMUTASE; THYROID HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; THYROID FUNCTION; THYROID HORMONE BLOOD LEVEL;

ACARBOSE; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CATALASE; DEXAMETHASONE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLUTATHIONE; HYPOGLYCEMIC AGENTS; INSULIN; KIDNEY; LIPID PEROXIDATION; MICE; MYOCARDIUM; SUPEROXIDE DISMUTASE; THYROID GLAND; THYROXINE; TRIIODOTHYRONINE;

EID: 33750077568     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04499.x     Document Type: Article

References (17)

1. Ganong WF. Review of Medical Physiology, 22nd edn. Appleton & Lange, Connecticut. 2005.
2. Roith DL, Taylor SI, Olefsky JM. Diabetes Mellitus: A Fundamental and Clinical Text. Lippincott-Raven, Philadelphia. 1996.
3. Peterson ME, Altszuler N, Nichols CE. Decreased insulin sensitivity and glucose tolerance in spontaneous canine hyper-adrenocorticism. Res. Vet. Sci. 1984; 36: 177-82.
4. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: Involvement of thyroid hormones. Pharmazie 2003; 58: 413-15.
5. Muller MJ, Moring J, Paschen U, Seitz HJ. Glucoregulatory function of thyroid hormones: Evidence for an insulin-independent effect. Exp. Clin. Endocrinol. 1989; 93: 313-20.
6. Lannello S, Milazzo P, Bordonaro F, Belfiore F. Effect of in vitro glucose and diabetic hyperglycemia on mouse kidney protein synthesis: Relevance to diabetic microangiopathy. Medscape Gen. Med. 2005; 7: 1-7.
7. Schafer A, Widder J, Eigenthaler M, Bischoff H, Ertl G, Bauersachs J. Increased platelet activation in young Zucker rats with impaired glucose tolerance is improved by acarbose. Thromb. Haemost. 2004; 92: 97-103.
8. Maiti PK, Kar A, Gupta P, Chaurasia SS. Loss of membrane integrity and inhibition of type-I iodothyronine 5′-monodeiodinase activity by fenvalerate in female mouse. Biochem. Biophys. Res. Commun. 1995; 214: 905-9.
9. Panda S, Kar A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5′D activity in adult male mice. Horm. Metab. Res. 2003; 35: 523-6.
10. Parmar HS, Panda S, Jatwa R, Kar A. Cardio-protective role of Terminalia arjuna bark extract is possibly mediated through alterations in thyroid hormones. Pharmazie 2006; 60 (in press).
11. Ohkawa H, Ohishi N, Yagi K. Assays of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979; 95: 351-8.
12. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin-phenol reagent. J. Biol. Chem. 1951; 193: 265-75.
13. Severino C, Brizzi P, Solinas A, Secchi G, Maioli M, Tonolo G. Lowdose dexamethasone in the rat: A model to study insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2002; 283: E367-73.
14. Delorme S, Chiasson JL. Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and type 2 diabetes mellitus. Curr. Opin. Pharmacol. 2005; 5: 184-9.
15. Zeymer U. Cardiovascular benefits of acarbose in impaired glucose tolerance and type 2 diabetes. Int. J. Cardiol. 2006; 107: 11-20.
16. Beenen OH, Pfaffendorf M, van Zwieten PA. Influence of the low thyroid state in diabetes mellitus on cardiac function and inotropic responsiveness to alpha 1-adrenoceptor stimulation: Comparison with the role of hypothyroidism alone. J. Cardiovasc. Pharmacol. 1996; 28: 553-7.
17. Maiti PK, Kar A. Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? J. Appl. Toxicol. 1998; 18: 125-8.