Cubebin and derivatives as inhibitors of mitochondrial complex I. Proposed interaction with subunit B8

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 2, 2009, Pages 599-606

  Saraiva, Juliana ^a   Siqueira, Claudia Meirelles ^a   De Paula Da Silva, Carlos Henrique Tomich ^a   Barreto Da Silva, Vinicius ^a   Tudella, Valeria Gomes ^a   Silva, Rosângela ^b   Andrade E Silva, Marcio Luis ^b   Dorta, Daniel Junqueira ^a   Bastos, Jairo Kenupp ^a   Uyemura, Srgio Akira ^a   De Albuquerque, Sérgio ^a   Curti, Carlos ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE DE FRANCA   (Brazil)

Author keywords

CI B8; Cubebin; Inhibition; Mitochondria; Mitochondrial complex I; NADH oxidase

Indexed keywords

BUTYROLACTONE; CUBEBIN; CUBEBIN DERIVATIVE; GLUTAMIC ACID; MALIC ACID; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) SUBUNIT 8; UNCLASSIFIED DRUG; LIGNAN; MULTIENZYME COMPLEX; OXIDOREDUCTASE; PROTEIN SUBUNIT;

ARTICLE; CALCULATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBUNIT; HAMSTER; IC 50; LIVER MITOCHONDRION; MALE; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; SUBMITOCHONDRIAL PARTICLE; ANIMAL; CELL RESPIRATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; KINETICS; METABOLISM; PROTEIN CONFORMATION;

CRICETINAE;

ANIMALS; CELL RESPIRATION; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; INHIBITORY CONCENTRATION 50; KINETICS; LIGNANS; MITOCHONDRIA, LIVER; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

EID: 68049109386     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802318845     Document Type: Article

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