Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells

Biochemical Pharmacology

Volumn 71, Issue 5, 2006, Pages 584-595

  Li, Ling ^a   Lu, Qinghua ^a   Shen, Yanwei ^a   Hu, Xun ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Cardiomyocytes; Caspase; Doxorubicin; Schisandrin B

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CASPASE 9; DOXORUBICIN; GLYCOPROTEIN P; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 1; REACTIVE OXYGEN METABOLITE; SCHISANDRA CHINENSIS EXTRACT; SCHISANDRIN B; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME ACTIVATION; FIBROBLAST; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOMA; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CASPASES; CELL LINE, TUMOR; CELLS, CULTURED; CYCLOOCTANES; DNA PRIMERS; DOXORUBICIN; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; LIGNANS; P-GLYCOPROTEIN; POLYCYCLIC COMPOUNDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 31044456677     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.11.026     Document Type: Article

References (35)

1. G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity Pharmacol Rev 56 2004 185 229
2. C. Friesen, I. Herr, P.H. Krammer, and K.M. Debatin Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells Nat Med 2 1996 574 577
3. S. Fulda, G. Strauss, E. Meyer, and K.M. Debatin Functional CD95 ligand and CD95 deathinducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells Blood 95 2000 301 308
4. S. Lacour, A. Hammann, A. Wotawa, L. Corcos, E. Solary, and M.T. Dimanche-Boitrel Anti-cancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis Cancer Res 61 2001 1645 1651
5. M.E. Clementi, B. Giardina, E. Di Stasio, A. Mordente, and F. Misiti Doxorubicin-derived metabolites induce release of cytochrome c and inhibition of respiration on cardiac isolated mitochondria Anti-cancer Res 23 2003 2445 2450
6. S.V. Kalivendi, S. Kotamraju, H. Zhao, J. Joseph, and B. Kalyanaraman Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase Effect of antiapoptotic antioxidants and calcium J Biol Chem 276 2001 47266 47276
7. R. Kim Recent advances in understanding the cell death pathways activated by anti-cancer therapy Cancer 103 2005 1551 1560
8. X. Bian, T.D. Giordano, H.J. Lin, G. Solomon, V.P. Castle, and A.W. Opipari Jr. Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation J Biol Chem 279 2004 4663 4669
9. Z. Cai, R. Stancou, M. Korner, and S. Chouaib Impairment of Fas-antigen expression in adriamycin-resistant but not TNF-resistant MCF7 tumor cells Int J Cancer 68 1996 535 546
10. S. Labialle, L. Gayet, E. Marthinet, D. Rigal, and L.G. Baggetto Transcriptional regulators of the human multidrug resistance 1 gene: recent views Biochem Pharmacol 64 2002 943 948
11. C.D. Scatena, Z.A. Stewart, D. Mays, L.J. Tang, C.J. Keefer, and S.D. Leach Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest J Biol Chem 273 1998 30777 30784
12. A.H. Dantzig, R.L. Shepard, J. Cao, K.L. Law, W.J. Ehlhardt, and T.M. Baughman Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator LY335979 Cancer Res 56 1996 4171 4179
13. Livingston RB Combined modality therapy of lung cancer Clin Cancer Res 12 1997 2638 2647 Pt 2
14. M.V. Osklonny, T. Fojo, K.N. Bhalla, J.S. Kim, J.B. Trepel, and W.D. Figg The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy Leukemia 10 2001 1537 1543
15. P.Y. Chiu, D.H. Mak, M.K. Poon, and K.M. Ko Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver Life Sci 13 2005 [Epub ahead of print]
16. P. Qiangrong, T. Wang, Q. Lu, and X. Hu Schisandrin B - a novel inhibitor of P-glycoprotein Biochem Biophys Res Commun 335 2005 406 411
17. T. Wang, F. Chen, Z. Chen, Y.F. Wu, X.L. Xu, and S. Zheng Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO World J Gastroenterol 10 2004 2205 2208
18. F. Chen, T. Wang, Y.F. Wu, Y. Gu, X.L. Xu, and S. Zheng Honokiol: a potent chemotherapy candidate for human colorectal carcinoma World J Gastroenterol 10 2004 3459 3463
19. T. Godard, E. Deslandes, P. Lebailly, C. Vigreux, L. Poulain, and F. Sichel Comet assay and DNA flow cytometry analysis of staurosporine-induced apoptosis Cytometry 36 1999 117 122
20. W.P. Tsang, S.P. Chau, K.P. Fung, S.K. Kong, and T.T. Kwok Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells Cancer Chemother Pharmacol 51 2003 161 166
21. B. Schiedlmeier, K. Kühlcke, H.G. Eckert, C. Baum, W.J. Zeller, and S. Fruehauf Quantitative assessment of retroviral gene transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice Blood 95 4 2000 1237 1248
22. M.G. Vander Heiden, N.S. Chandel, E.K. Williamson, P.T. Schumacker, and C.B. Thompson Bcl-xl regulates the membrane potential and volume homeostasis of mitochondria Cell 91 1997 627 637
23. R.K. Emaus, R. Grunwald, and J.J. Lemasters Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties Biochim Biophys Acta 850 3 1986 436 448
24. L.B. Chen Fluorescent labeling of mitochondria Method Cell Biol 9 1989 103 123
25. E. Yague, A.L. Armesilla, G. Harrison, J. Elliott, A. Sardini, and C.F. Higgins P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation J Biol Chem 278 2003 10344 10352
26. C. Nakahara, K. Nakamura, N. Yamanaka, E. Baba, M. Wada, and H. Matsunaga Cyclosporin-A enhances docetaxel-induced apoptosis through inhibition of nuclear factor-kappaB activation in human gastric carcinoma cells Clin Cancer Res 9 2003 5409 5416
27. T. Kamio, T. Toki, R. Kanezaki, S. Sasaki, S. Tandai, and K. Terui B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anti-cancer drugs Blood 102 9 2003 3317 3322
28. I. Marzo, S.A. Susin, P.X. Petit, L. Ravaganan, C. Brenner, and N. Larochette Caspase disrupt mitochondrial memberane barrier function FEBS Lett 427 1998 198 202
29. T.K. Yeung, K. Chakrabarti, D. Wilding, and J.W. Hopewell Modification of doxorubicin-induced cardiotoxicity: manipulation of the dosage schedule Hum Exp Toxicol 21 2002 607 614
30. 2- and p53-dependent pathways J Biol Chem 279 2004 25535 25543
31. P.Y. Chiu, M.H. Tang, D.H.F. Mak, M.K.T. Poon, and K.M. Ko Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins Free Radical Biol Med 35 2003 368 380
32. P.Y. Chiu, and K.M. Ko Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats Mol Cell Biochem 266 2004 139 144
33. S.P. Ip, and K.M. Ko The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene Biochem Pharmacol 52 11 1996 1687 1693
34. S.P. Ip, M.K. Poon, C.T. Che, K.H. Ng, Y.C. Kong, and K.M. Ko Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver Free Radical Biol Med 21 5 1996 709 712
35. J.L. Hancke, R.A. Burgos, and F. Ahumanda Schisandra chinensis (Turcz.) Bail Fitoterapia 70 1999 451 471