Pentacyclic furanosteroids: The synthesis of potential kinase inhibitors related to viridin and wortmannolone

Journal of Organic Chemistry

Volumn 74, Issue 15, 2009, Pages 5429-5439

  Lang, Yunhui ^a   Souza, Fabio E S ^a   Xu, Xinshe ^a   Taylor, Nicholas J ^a   Assoud, Abdeljalil ^a   Rodrigo, Russell ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOQUINONE; CHEMICAL EQUATIONS; DIHYDROXYLATION; DOUBLE BONDS; IN-SITU; INTERMOLECULAR DIELS-ALDER REACTIONS; INTRAMOLECULAR DIELS-ALDER REACTION; KINASE INHIBITORS; NATURAL PRODUCTS; NITRILE OXIDES; SILYL SUBSTITUENTS; TRIMETHYLSILYL;

CHEMICAL BONDS; CYANIDES; NITROGEN OXIDES; OXYGEN; SILANES; STEREOCHEMISTRY;

SYNTHESIS (CHEMICAL);

(TETRAHYDROFURANYL 2' OXO)BUTANAL; 1 IODO 6 HEPTADIENE; 1 NITRO 6 HEPTADIENE; 1,2 BENZOQUINONE; 1ALPHA TRIMETHYLSILYL 11BBETA METHYL 1,6,7,8,9,11B HEXAHYDROCYCLOPENTA[7,8]PHENANTHRO[10,1 BC]FURAN 6,9 DIONE; 1ALPHA TRIMETHYLSILYL 11BBETA METHYL 5A,11C EPOXY 1,3A,4,5A,6,7,8,9,11B,11C DECAHYDROCYCLOPENTA[7,8]PHENANTHRO[10,1 BC]FURAN 6,9 DIONE; 1ALPHA TRIMETHYLSILYL 2BETA,3BETA DIHYDROXY 11BBETA METHYL 1,2,3,6,7,8,9,11B OCTAHYDROCYCLOPENTA[7,8] PHENANTHRO[10,1 BC]FURAN 6,9 DIONE; 1ALPHA,2ALPHA EPOXY 3BETA HYDROXY 11BBETA METHYL 1,2,3,6,7,8,9,11B TAHYDRO[7,8]PHENANTHRO[10,1 BC]FURAN 6,9 DIONE; 2 BROMOVINYL)TRIMETHYLSILANE; 2 HYDROXY 3 METHOXY 5 METHYLBENZOIC ACID; 2 METHOXY 4 METHYL 8 (3 NITROPROPYL) 5,8 DIHYDRONAPHTHALENE 1 OL; 2,3 DIHYDROXY 5 METHYLBENZOIC ACID; 3BETA HYDROXY 11BBETA METHYL 3,6,7,8,9,11B HEXAHYDRO[7,8]PHENANTHRO[10,1 BC]FURAN 6,9 DIONE; 4 METHYL 8 (3 NITROPROPYL) 5,8 DIHYDRONAPHTHALENE 1,2 DIOL; 5 (TRIMETHYLSILYL)PENT 4 EN 2 YN 1 OL; 5 (TRIMETHYLSILYL)PENTA 2,4 DIEN 1 OL; 5 TRIMETHYLSILYL PENTADIENOL; 8 METHOXY 4 HYDROXY 6 METHYL 9 O TERT BUTYLOXYCARBONYL 2,3,3A,4,5,9B HEXAHYDRO 1H BENZ[E]INDEN 3 ONE; 8 METHOXY 4 HYDROXY 6METHYL 9 HYDROXY 1,2,5,9B HEXAHYDRO 1H BENZ[E]INDEN 3 ONE; 8 METHOXY 6 METHYL 1,2,4A,5,9B,9C HEXAHYDROBENZO[4,5]INDENO[1,7 CD]ISOXAZOL 9 YL TERT BUTYLCARBONATE; BENZOQUINONE DERIVATIVE; HEPTA 6 DIENOL; HYDROGEN SULFITE REDUCTASE; NITRILE OXIDE; OXYGEN; PENTACYCLIC FURANOSTEROID DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; STEROID; TRIMETHYLSILYL 2BETA,3BETA DIHYDROXY PENTACYCLE; UNCLASSIFIED DRUG; WORTMANNOLONE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; DIELS ALDER REACTION; DIHYDROXYLATION; SILYLATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; SYNTHESIS;

ANDROSTADIENES; ANDROSTENES; BACTERIOCINS; BENZOQUINONES; CYCLIZATION; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STEREOISOMERISM;

EID: 68049083714     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo900922q     Document Type: Article

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