A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice

Journal of Thrombosis and Haemostasis

Volumn 7, Issue 8, 2009, Pages 1384-1392

  Liu, J ^a   Kanki, Y ^b   Okada, Y ^a   Jin, E ^a   Yano, K ^a   Shih, S C ^a   Minami, T ^b   Aird, William C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

GATA; Hprt targeting; Promoter; Sepsis; von Willebrand factor

Indexed keywords

BETA GALACTOSIDASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR GATA 6; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL TYPE; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENDOTOXEMIA; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOCUS; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; GATA TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; VON WILLEBRAND FACTOR;

EID: 67949105048     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2009.03501.x     Document Type: Article

References (34)

1. Ruggeri ZM. The role of von Willebrand factor in thrombus formation. Thromb Res 2007; 120: S5-9.
2. Sadler JE. von Willebrand factor: Two sides of a coin. J Thromb Haemost 2005; 3: 1702-9.
3. Aird WC. Endothelial cell heterogeneity. Crit Care Med 2003; 31: S221-30.
4. Yamamoto K, de Waard V, Fearns C, Loskutoff DJ. Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo. Blood 1998; 92: 2791-801.
5. Jahroudi N, Lynch DC. Endothelial-cell-specific regulation of von Willebrand factor gene expression. Mol Cell Biol 1994; 14: 999-1008.
6. Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci U S A 1995; 92: 4567-71.
7. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol 1997; 138: 1117-24.
8. Guan J, Guillot PV, Aird WC. Characterization of the mouse von Willebrand factor promoter. Blood 1999; 94: 3405-12.
9. Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD. PDGF mediates cardiac microvascular communication. J Clin Invest 1998; 102: 837-43.
10. Kleinschmidt AM, Nassiri M, Stitt MS, Wasserloos K, Watkins SC, Pitt BR, Jahroudi N. Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. J Biol Chem 2008; 283: 2741-50.
11. Minami T, Aird WC. Endothelial cell gene regulation. Trends Cardiovasc Med 2005; 15: 174-84.
12. Bronson SK, Plaehn EG, Kluckman KD, Hagaman JR, Maeda N, Smithies O. Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A 1996; 93: 9067-72.
13. Guillot PV, Liu L, Kuivenhoven JA, Guan J, Rosenberg RD, Aird WC. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics 2000; 2: 77-83.
14. Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, Kuivenhoven JA. Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics 2000; 2: 67-75.
15. Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol 2003; 23: 2041-7.
16. Minami T, Donovan DJ, Tsai JC, Rosenberg RD, Aird WC. Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyl transferase-targeted mice. Blood 2002; 100: 4019-25.
17. Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. Circ Res 2007; 100: 1712-22.
18. Schwachtgen JL, Janel N, Barek L, Duterque-Coquillaud M, Ghysdael J, Meyer D, Kerbiriou-Nabias D. Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene. Oncogene 1997; 15: 3091-102.
19. Schwachtgen JL, Remacle JE, Janel N, Brys R, Huylebroeck D, Meyer D, Kerbiriou-Nabias D. Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter. Blood 1998; 92: 1247-58.
20. Peng Y, Jahroudi N. The NFY transcription factor functions as a repressor and activator of the von Willebrand factor promoter. Blood 2002; 99: 2408-17.
21. Jahroudi N, Ardekani AM, Greenberger JS. An NF1-like protein functions as a repressor of the von Willebrand factor promoter. J Biol Chem 1996; 271: 21413-21.
22. Hough C, Cuthbert CD, Notley C, Brown C, Hegadorn C, Berber E, Lillicrap D. Cell type-specific regulation of von Willebrand Factor expression by the E4BP4 transcriptional repressor. Blood 2005; 105: 1531-9.
23. Peng Y, Jahroudi N. The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases. J Biol Chem 2003; 278: 8385-94.
24. Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T, Kodama T. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol 2001; 21: 917-22.
25. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T, Kodama T, Aird WC. Vascular endothelial growth factor- and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem 2004; 279: 50537-54.
26. Minami T, Aird WC. Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J Biol Chem 2001; 276: 47632-41.
27. Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC- zeta-GATA signaling pathways. J Biol Chem 2003; 278: 6976-84.
28. Minami T, Rosenberg RD, Aird WC. Transforming Growth Factor-beta 1-mediated Inhibition of the flk-1/KDR Gene Is Mediated by a 5′-Untranslated Region Palindromic GATA Site. J Biol Chem 2001; 276: 5395-402.
29. Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC. A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood 2008; 112: 2336-9.
30. McLaughlin F, Ludbrook VJ, Cox J, von Carlowitz I, Brown S, Randi AM. Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation. Blood 2001; 98: 3332-9.
31. McLaughlin F, Ludbrook VJ, Kola I, Campbell CJ, Randi AM. Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter. J Cell Sci 1999; 112: 4695-703.
32. McLaughlin F, Hayes BP, Horgan CM, Beesley JE, Campbell CJ, Randi AM. Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta down-regulate intercellular adhesion molecule (ICAM)-2 expression on the endothelium. Cell Adhes Commun 1998; 6: 381-400.
33. Harvey PJ, Keightley AM, Lam YM, Cameron C, Lillicrap D. A single nucleotide polymorphism at nucleotide -1793 in the von Willebrand factor (VWF) regulatory region is associated with plasma VWF:AG levels. Br J Haematol 2000; 109: 349-53.
34. Keightley AM, Lam YM, Brady JN, Cameron CL, Lillicrap D. Variation at the von Willebrand factor (vWF) gene locus is associated with plasma vWF:IG levels: identification of three novel single nucleotide polymorphisms in the vWF gene promoter. Blood 1999; 93: 4277-83.