Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats

Neuroscience

Volumn 162, Issue 4, 2009, Pages 1192-1201

  Mizoguchi, K ^a   Shoji, H ^a   Tanaka, Y ^a   Maruyama, W ^a   Tabira, T ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

aging; cognitive function; D1 receptor; dopamine; prefrontal cortex; tyrosine hydroxylase

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE; DOPAMINE 1 RECEPTOR; TYROSINE 3 MONOOXYGENASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINERGIC ACTIVITY; ENZYME ACTIVITY; ENZYME ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; MEMORY DISORDER; NEUROPATHOLOGY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; SUBSTANTIA NIGRA; TASK PERFORMANCE; VENTRAL TEGMENTUM; WORKING MEMORY;

AGING; ANIMALS; BENZAZEPINES; DOPAMINE; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; NEURONS; PREFRONTAL CORTEX; RATS; RATS, INBRED F344; RECEPTORS, DOPAMINE D1; SPATIAL BEHAVIOR; SYNAPTIC TRANSMISSION; TYROSINE 3-MONOOXYGENASE;

EID: 67949097322     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.05.023     Document Type: Article

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