Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints

Bone

Volumn 45, Issue 3, 2009, Pages 414-422

  Stok, Kathryn S ^a   Pelled, Gadi ^b   Zilberman, Yoram ^b   Kallai, Ilan ^b   Goldhahn, Jörg ^a,c   Gazit, Dan ^b,d   Müller, Ralph ^a  

^a ETH ZURICH   (Switzerland)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c SCHULTHESS CLINIC   (Switzerland)

^d CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Bone; Cartilage; Confocal laser scanning microscopy; Microcomputed tomography; Morphometry; Murine models; Osteoarthritis; STR ort

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORTICAL BONE; DISEASE COURSE; DISEASE MODEL; EPIPHYSIS; MALE; METAPHYSIS; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PHENOTYPE; QUANTITATIVE ANALYSIS; STRAIN DIFFERENCE; THREE DIMENSIONAL IMAGING;

AGING; ANIMALS; BONE AND BONES; CARTILAGE, ARTICULAR; IMAGING, THREE-DIMENSIONAL; KNEE JOINT; MALE; MICE; MICROSCOPY, CONFOCAL; OSTEOARTHRITIS; X-RAY MICROTOMOGRAPHY;

EID: 67949086637     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.05.017     Document Type: Article

References (34)

1. Altman R.D., and Dean D.D. Osteoarthritis research: animal models. Semin. Arthritis Rheum. 19 (1990) 21-25
2. Creamer P., and Hochberg M.C. Osteoarthritis. Lancet 350 (1997) 503-509
3. Felson D.T. Clinical practice. Osteoarthritis of the knee. N. Engl. J. Med. 354 (2006) 841-848
4. Hunter D.J., and Felson D.T. Osteoarthritis. BMJ 332 (2006) 639-642
5. Nevitt M.C., Lane N.E., Scott J.C., Hochberg M.C., Pressman A.R., Genant H.K., et al. Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 38 (1995) 907-916
6. Bobinac D., Spanjol J., Zoricic S., and Maric I. Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 32 (2003) 284-290
7. Martin D.F. Pathomechanics of knee osteoarthritis. Med. Sci. Sports Exerc. 26 (1994) 1429-1434
8. Chambers M.G., Bayliss M.T., and Mason R.M. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthr. Cartil. 5 (1997) 301-308
9. Chambers M.G., Kuffner T., Cowan S.K., Cheah K.S., and Mason R.M. Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints. Osteoarthr. Cartil. 10 (2002) 51-61
10. Flannelly J., Chambers M.G., Dudhia J., Hembry R.M., Murphy G., Mason R.M., et al. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthr. Cartil. 10 (2002) 722-733
11. Gaffen J.D., Bayliss M.T., and Mason R.M. Elevated aggrecan mRNA in early murine osteoarthritis. Osteoarthr. Cartil. 5 (1997) 227-233
12. Joosten L.A.B., Van de Loo F.A.J., Van der Kraan P.M., Lubberts E., and Van den Berg W.B. IL-18 drives cartilage destruction in murine osteoarthritis. Trans. Orthop. Res. Soc. (2003) 49 Paper 0736
13. Sokoloff L. Natural history of degenerative joint disease in small laboratory animals. I. Pathological anatomy of degenerative joint disease in mice. AMA. Arch. Pathol. 62 (1956) 118-128
14. Walton M. Degenerative joint disease in the mouse knee; radiological and morphological observations. J. Pathol. 123 (1977) 97-107
15. Price J.S., Chambers M.G., Poole A.R., Fradin A., and Mason R.M. Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis. Osteoarthr. Cartil. 10 (2002) 172-179
16. Gaffen J.D., Gleave S.J., Crossman M.V., Bayliss M.T., and Mason R.M. Articular cartilage proteoglycans in osteoarthritic STR/Ort mice. Osteoarthr. Cartil. 3 (1995) 95-104
17. Mistry D., Oue Y., Chambers M.G., Kayser M.V., and Mason R.M. Chondrocyte death during murine osteoarthritis. Osteoarthr. Cartil. 12 (2004) 131-141
18. Mason R.M., Chambers M.G., Flannelly J., Gaffen J.D., Dudhia J., and Bayliss M.T. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthr. Cartil. 9 (2001) 85-91
19. Schwartz A., Gaigalas A.K., Wang L.L., Marti G.E., Vogt R.F., and Fernandez-Repollet E. Formalization of the MESF unit of fluorescence intensity. Cytom. Part. B-Clin. Cy. 57B (2004) 1-6
20. Kohler T., Stauber M., Donahue L.R., and Müller R. Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models. Bone 41 (2007) 659-667
21. Trussell H.J. Picture thresholding using an iterative selection method - comments. IEEE. T. Syst. Man. Cyb. 9 (1979) 311
22. Hildebrand T., Laib A., Müller R., Dequeker J., and Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 14 (1999) 1167-1174
23. Kohler T., Beyeler M., Webster D., and Muller R. Compartmental bone morphometry in the mouse femur: reproducibility and resolution dependence of microtomographic measurements. Calcif. Tissue. Int. 77 (2005) 281-290
24. Stok K., and Müller R. Morphometric characterisation of murine articular cartilage - novel application of confocal laser scanning microscopy. Microsc. Res. Tech. (2009)
25. Collins C., Evans R.G., Ponsford F., Miller P., and Elson C.J. Chondro-osseous metaplasia, bone density and patellar cartilage proteoglycan content in the osteoarthritis of STR/ORT mice. Osteoarthr. Cartil 2 (1994) 111-118
26. Montgomery D.C. Design and analysis of experiments. 4th ed. (1997), John Wiley & Sons, New York
27. Beary III J.F. Joint structure modification in osteoarthritis: development of SMOAD drugs. Curr. Rheumatol. Rep. 3 (2001) 506-512
28. Nalbant S., Martinez J.A., Kitumnuaypong T., Clayburne G., Sieck M., and Schumacher Jr. H.R. Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies. Osteoarthr. Cartil. 11 (2003) 50-54
29. Boyd S.K., Müller R., and Zernicke R.F. Mechanical and architectural bone adaptation in early stage experimental osteoarthritis. J. Bone. Miner. Res. 17 (2002) 687-694
30. Sondergaard B.C., Oestergaard S., Christiansen C., Tanko L.B., and Karsdal M.A. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum. 56 (2007) 2674-2678
31. Qvist P., Bay-Jensen A.C., Christiansen C., Dam E.B., Pastoureau P., and Karsdal M.A. The disease modifying osteoarthritis drug (DMOAD): is it in the horizon?. Pharmacol. Res. 58 (2008) 1-7
32. Karsdal M.A., Leeming D.J., Dam E.B., Henriksen K., Alexandersen P., Pastoureau P., et al. Should subchondral bone turnover be targeted when treating osteoarthritis?. Osteoarthr. Cartil. 16 (2008) 638-646
33. Patel V., Issever A.S., Burghardt A., Laib A., Ries M., and Majumdar S. MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J. Orthop. Res. 21 (2003) 6-13
34. Lindsey C.T., Narasimhan A., Adolfo J.M., Jin H., Steinbach L.S., Link T., et al. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthr. Cartil. 12 (2004) 86-96