Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints

Osteoarthritis and Cartilage

Volumn 10, Issue 1, 2002, Pages 51-61

  Chambers, M G ^a   Kuffner, T ^b   Cowan, S K ^b   Cheah, K S E ^b   Mason, R M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aggrecan expression; Collagen expression; Murine osteoarthritis; STR ort mouse

Indexed keywords

AGGRECAN; COLLAGEN; COLLAGEN TYPE 10; COLLAGEN TYPE 11; COLLAGEN TYPE 2; SCLEROPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BONE MATURATION; BONE REMODELING; CARTILAGE; CARTILAGE CELL; CELL GROWTH; CONNECTIVE TISSUE; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; KNEE; KNEE CRUCIATE LIGAMENT; KNEE MENISCUS; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OSTEOARTHRITIS; PATELLOFEMORAL JOINT; PLATING MEDIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TIBIA;

EID: 0036151195     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.2001.0481     Document Type: Article

References (58)

1. Structure and function of cartilage collagens
2. Cartilage proteoglycans: Structure and potential functions
3. The mechanical properties of cartilage
4. Collagen synthesis in normal and osteoarthritic human cartilage
5. Collagen synthesis in mature articular cartilage of the rabbit
6. Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis
7. Immunohistochemical detection and immunohistochemical analysis of type II collagen degradation in human normal, rheumatoid and osteoarthritic cultured with interleukin 1
8. Increased damage to type II collagen in osteoarthritic articular cartilage detected by new immunoassay
9. Proteolytic degradation of normal and osteoarthritic cartilage matrix
10. Collagen family of proteins
11. Cartilage contains mixed fibrils of collagen types II, IX and XI
12. Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly
13. Isolation of human type X collagen and immunolocalization in fetal human cartilage
14. Type X collagen, a natural component of mouse articular cartilage
15. Collagen type X: A component of the surface of normal human, pig and rat articular cartilage
16. Immunoelectron microscopy of type X collagen: Supramolecular forms within embryonic chick cartilage
17. Macromolecular organisation of chicken type X collagen in vitro
18. Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy
19. Expression of type X collagen in osteoarthritis
20. Differential expression of collagen types I, II, III, and X in human osteophytes
21. Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage
22. Two distinct metabolic pools of proteoglycans in articular cartilage
23. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. III. Distribution and metabolism of amino sugar-containing macromolecules
24. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data
25. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints
26. The STR/ort mouse and its use as a model of osteoarthritis
27. Chondro-osseous metaplasia, bone density and patellar cartilage proteoglycan content in the osteoarthritis of STR/ort mice
28. In situ hybridisation and the three dimensional reconstruction of serial sections
29. Preferential expression of alternatively spliced mRNAs encoding type II procollagen with a cysteine-rich amino-propeptide in differentiating cartilage and nonchondrogenic tissues during early mouse development
30. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
31. Intron-exon structure, alternative use of promoter and expression of the mouse collagen X gene, Col10α1
32. Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development
33. Disrupted expression of matrix genes in the growth plate of the mouse cartilage deficiency (cmd)
34. Expression of the mouse alpha 1(II) collagen gene is not restricted to cartilage during development
35. Abnormal compartmentalisation of cartilage matrix components in mice lacking collagen X: Implications for function
36. Chondrocyte cytokine and growth factor expression in murine osteoarthritis
37. Expression of collagen types IX and XI and other major cartilage matrix components by human fetal chondrocytes in vivo
38. Cartilage Collagens. What is their function, and are they involved in articular disease?
39. The organisation of aggrecan in human articular cartilage. Evidence for age-related changes in the rate of aggregation of newly synthesised molecules
40. Maintenance of the synthesis of large proteoglycans is anatomically intact murine articular cartilage by steroids and insulin-like growth factor 1
41. Autosomal dominant and recessive osteochondrodysplasia associated with the COL11A2 locus
42. Type XI collagen-degrading activity in human osteoarthritic cartilage
43. Neutral matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritis lesions in STR/ort mice
44. Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage
45. Reexpression of type IIA procollagen by adult articular chondrocytes in osteoarthritic cartilage
46. The early molecular natural history of experimental osteoarthritis. I. Progressive discoordinate expression of aggrecan and type II procollagen messenger RNA in the articular cartilage of adult animals
47. Chondrocyte apoptosis accompanies lesion development in murine osteoarthritis
48. Type X collagen expression in osteoarthritic and rheumatoid articular cartilage
49. Expression of collagens I, II, X, and XI and aggrecan mRNAs by bovine growth plate chondrocytes in situ
50. Zonal variations of type II, IX and XI collagen mRNAs in rat epiphyseal cartilage chondrocytes: Quantitative evaluation of in situ hybridisation by image analysis of radioautography
51. Blood and lymph supply of the posterior cruciate ligament: A cadaver study
52. Biochemical Analysis of collagens at the ligament-bone interface reveals presence of cartilage-specific collagens
53. An immunohistochemical study of enthesis development in the medial collateral ligament in the rat knee joint
54. Identification and immunolocalisation of type X collagen at the ligament-bone interface
55. Identification of types II, IX and X collagens in the insertion site of the bovine achilles tendon
56. Proteoglycans in the compressed region of human tibialis posterior tendon and in ligaments
57. Characterisation of a large chondroitin sulfate proteoglycan present in bovine collateral ligament
58. Proteins in the tensile region of adult bovione deep flexor tendon