Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1784, Issue 11, 2008, Pages 1652-1658

  Guianvarc'h, Dominique ^a,b   Guangqi E, ^b,c   Drujon, Thierry ^a,b   Rey, Camille ^a,b   Wang, Qian ^b   Ploux, Olivier ^b,c  

^a Centre National de la Recherche Scientifique   (France)

^b CNRS   (France)

^c PSL RESEARCH UNIVERSITY   (France)

Author keywords

Antibiotic; Cyclopropane synthase; Inhibition; Screening

Indexed keywords

CYCLOPROPANE; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; INDOLOQUINOLINE DERIVATIVE; OCTYLAMINE; PHOSPHOLIPID; S ADENOSYLMETHIONINE; SINEFUNGIN;

ARTICLE; BACTERIAL CELL; BINDING SITE; CHEMICAL STRUCTURE; COLORIMETRY; CONTROLLED STUDY; CYCLOPROPANATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; IC 50; IN VIVO STUDY; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ADENOSINE; ANTI-BACTERIAL AGENTS; CATALYSIS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACIDS; METHYLTRANSFERASES; MODELS, BIOLOGICAL; SMALL MOLECULE LIBRARIES;

ESCHERICHIA COLI;

EID: 54149097924     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.04.019     Document Type: Article

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