Synthesis and anti-HSV-1 activity of 1,4-dihydro-4-oxoquinoline ribonucleosides

Letters in Drug Design and Discovery

Volumn 4, Issue 6, 2007, Pages 404-409

  Canuto, Carla Verônica B Dos S ^a   Gomes, Claudia R B ^a   Marques, Isakelly P ^a   Faro, Letícia V ^a   Santos, Fernanda Da Costa ^a   Frugulhetti, Izabel Christina De P P ^a   E Souza, Thiago M L ^b   Cunha, Anna C ^a   Romeiro, Gilberto A ^a   Ferreira, Vitor F ^a   De Souza, Maria Cecília B V ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Anti HSV 1; Nucleosides; Oxoquinolineribonucleosides

Indexed keywords

1,4 DIHYDRO 4 OXOQUINOLINE; 6 BROMO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 6 CHLORO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 6 FLUORO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 6 METHOXY 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 6 METHYL 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 7 BROMO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 7 CHLORO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 7 FLUORO 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 7 METHOXY 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; 7 METHYL 1,4 DIHYDRO 4 OXO 1 (BETA DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; RIBONUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; PRIORITY JOURNAL;

EID: 35349025361     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018007781387818     Document Type: Article

References (21)

1. Wagner, E.K.; Bloom, D.C. Clin. Microbiol. Rev., 1997, 10 (3), 419.
2. Coen, D.M.; Shaffer, P.A. Nat. Rev . Drug Discov., 2003, 2, 278.
3. Elzuru, Y. Antivir. Chem. Chemother., 2003, 14 (6), 299.
4. Van Bambeke F.; Michot, J.M.; Van Eldere, J.; Tulkens, P.M. Clin. Microbiol. Infect., 2005, 11, 256.
5. Nasr, M.; Drach, J.C.; Smith, S.H.; Shipman, C.; Burchalter, J.H. J. Med. Chem., 1998, 31, 1347.
6. De Clercq, E. Il Farmaco, 2001, 56 (1-2), 3.
7. De Clercq, E. Curr. Opin. in Microbiol., 2005, 8 (5), 552.
8. De Clercq, E. J. Clin. Virol., 2004, 30, 115.
9. Da Matta, A.D.; Bernardino, A.M.R.; Romeiro, G.A.; De Oliveira, M.R.P.; De Souza, M.C.B.V.; Ferreira, V.F. Nucleosides Nucleotides, 1996, 15 (4), 889.
10. Niedballa, U.; Vorbrüggen, H. J. Org. Chem, 1974,. 39 (25), 3668.
11. De La Cruz, A.; Elguero, J.; Goya, P.; Martinez, A.; De Clercq, E. J. Chem. Soc. Perkin Trans.1, 1993, 845.
12. Da Matta, A D.; Dos Santos, C.V.; Pereira, H.,Frugulhetti; I.C. de P. P.; Pereira, M. R.; De Souza, M.C. B. V.; Moussatché, N.; Ferreira. V. F. F. Heteroat. Chem., 1999, 10 (3), 197.
13. Deffin, G.F ; Kendall, J.D. J. Am. Chem. Soc., 1948, 70, 893.
14. Snyder, H.R.; Freier, H.E.; Kovacic, P.; Heyningen, E.M.V. J. Am. Chem. Soc., 1947, 69, 371.
15. Lauer, W.M.; Arnold, R.T.; Tiffany, B.; Tinker, H. J. Am. Chem. Soc., 1946, 68, 1268.
16. Ramsey, V.G.; Cretcher, L.H. J. Am. Chem. Soc., 1947, 69, 1659.
17. Riegel, B.; Lappin, G.R.; Adelson, B.H.; Jackson, R.I.; Albisetti Jr., C.J.; Dodson, R.M.; Baker, R.H. J. Am. Chem. Soc., 1946, 68, 1264.
18. Roberts, R.B. J. Am. Chem. Soc., 1948, 70, 277.
19. Lagrota, M.H.C.; Wigg, M.D.; Santos, M.M.G.; Miranda, M.M.F.S.; Câmara,F.P.; Couceiro, J.N.; Costa, S.S. Phytother.Res., 1994, 8, 358.
20. Reed, J.L.; Muench, H.A. Am. J. Hyg., 1938, 27, 493.
21. Mosmann, T. J. Immunol. Methods, 1983, 65, 55.