Ghrelin and resistin levels in children with epilepsy on valproic acid

Journal of Pediatric Neurology

Volumn 7, Issue 3, 2009, Pages 223-229

  Tomoum, Hoda Y ^a,b   El Hadidi, Eman S ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b NONE   (Egypt)

Author keywords

Children; Epilepsy; Ghrelin; Resistin; Valproic acid

Indexed keywords

GHRELIN; RESISTIN; VALPROIC ACID;

ADOLESCENT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; EPILEPSY; FEMALE; GRAND MAL EPILEPSY; HUMAN; IDIOPATHIC DISEASE; MALE; MONOTHERAPY; PROTEIN BLOOD LEVEL;

EID: 67749118173     PISSN: 13042580     EISSN: 18759041     Source Type: Journal    
DOI: 10.3233/JPN-2009-0310     Document Type: Article

References (43)

1. E. Perucca, Pharmacological and therapeutic properties of valproate: A summary after 35 years of clinical experience, CNS Drugs 16 (2002), 695-714.
2. V. Biton, W. Mirza, G. Montouris, A. Vuong, A.E. Hammer and P.S. Barrett, Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy, Neurology 56 (2001), 172-177.
3. A. Verrotti, R. Greco, G. Latini and F. Chiarelli, Endocrine and metabolic changes in epileptic patients receiving valproic acid, J Pediatr Endocrinol Metab 18 (2005), 423-430.
4. E. Demir and S. Aysun,Weight gain associated with valproate in childhood, Pediatr Neurol 22 (2000), 361-364.
5. H.A. El-Khayat, F.Z. Abd El-Basset, H.Y. Tomoum et al., Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy, Epilepsia 45 (2004), 1106-1115.
6. P. Jallon and F. Picard, Body weight gain and anticonvulsants, Drug Saf 24 (2001), 969-978.
7. C.L. Corman, N.M. Leung A.H. Guberman, Weight gain in epileptic patients during treatment with valproic acid: A retrospective study, Can J Neurol Sci 24 (1997), 240-244.
8. D.L. Williams and D.E. Cummings, Regulation of ghrelin in physiologic and pathophysiologic states, J Nutr 135 (2005), 1320-1325.
9. Y. Minokoshi, T. Alquier, N. Furukawa et al., AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus, Nature 428 (2004), 569-574.
10. U. Andersson, K. Filipsson, C.R. Abbott et al., AMP-activated protein kinase plays a role in the control of food intake, J Biol Chem 279 (2004), 12005-12008.
11. L. Brunetti, L. Recinella, G. Orlando, B. Michelotto, C. Di Nisio and M. Vacca, Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus, Eur J Pharmacol 454 (2002), 189-192.
12. P.G. McTernan, C.M. Kusminski and S. Kumar, Resistin, Curr Opin Lipidol 17 (2006), 170-175.
13. M. Degawa-Yamauchi, J.E. Bovenkerk, B.E. Juliar et al., Serum resistin (FIZZ3) protein is increased in obese humans, J Clin Endocrinol Metab 88 (2003), 5452-5455.
14. C. Asensio, P. Cettour-Rose, C. Theander-Carrillo, F. Rohner-Jeanrenaud and P. Muzzin, Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis, Endocrinology 145 (2004), 2206-2213.
15. J.H. Lee, J.W. Bullen, V.L. Stoyneva and C.S. Mantzoros, Circulating resistin in lean, obese, and insulin-resistant mouse models: Lack of association with insulinemia and glycemia, Am J Physiol Endocrinol Metab 288 (2005), E625-E632.
16. N.S. Singhal, R.T. Patel, Y. Qi, Y.S. Lee and R.S. Ahima, Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice, Am J Physiol Endocrinol Metab 295 (2008), E331-E338.
17. G. Valsamakis, P.G. McTernan, R. Chetty et al., Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines, Metab Clin Exp 53 (2004), 430-434.
18. J.M. Tanner, R.H. Whitehouse and M. Takaishi, Standards from birth to maturity for height, weight, height velocity, weight velocity, Arch Dis Child 41 (1966), 613.
19. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy, Epilepsia 30 (1989), 389-399.
20. M.R. Skilton and D.S. Celermajer, The effects of obesity-related peptides on the vasculature, Curr Vasc Pharmacol 4 (2006), 79-85.
21. M. Korbonits, A.P. Goldstone, M. Gueorguiev and A.B. Grossman, Ghrelin-a hormone with multiple functions, Front Neuroendocrinol 25 (2004), 27-68.
22. Y. Date, N. Murakami, K. Toshinai et al., The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats, Gastroenterology 123 (2002), 1120-1128.
23. V. Biton, W. Mirza, G. Montouris, A. Vuong, A.E. Hammer and P.S. Barrett, Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy, Neurology 56 (2001), 172-177.
24. P. Jallon and F. Picard, Body weight gain and anticonvulsants, Drug Saf 24 (2001), 969-978.
25. M.S. Berilgen, B. Mungen, B. Ustundag and C. Demir, Serum ghrelin levels are enhanced in patients with epilepsy, Seizure 15 (2006), 106-111.
26. S. Gungor, G. Yücel, A. Akinci, Y. Tabel, I.H. Ozerol and S. Yologlu, The role of ghrelin in weight gain and growth in epileptic children using valproate, J Child Neurol 22 (2007), 1384-1388.
27. M. Nakazato, N. Murakami, Y. Date et al., A role for ghrelin in the central regulation of feeding, Nature 409 (2001), 194-198.
28. R. Greco, G. Latini, F. Chiarelli, P. Ianetti and A. Verotti, Leptin, ghrelin, and adinopectin in epileptic patients treated with valproic acid, Neurology 65 (2005), 1808-1809.
29. A.G. Herzog, A hypothesis to integrate partial seizures of temporal lobe origin and reproductive endocrine disorders, Epilepsy Res 3 (1989), 151-159.
30. L. Bilo, R. Meo, R. Valentino, G.A. Buscaino, S. Striano and Nappi, Abnormal pattern of luteinizing hormone pulsatility in women with epilepsy, Fertil Steril 55 (1991), 705-711.
31. P.B. Pritchard, The effect of seizures on hormones, Epilepsia 32(Suppl 6) (1991), S46-S50.
32. H. Meierkord, S. Shorvon and S.L. Lightman, Plasma concentrations of prolactin, noradrenaline, vasopressin and oxytocin during and after a prolonged epileptic seizure, Acta Neurol Scand 90 (1994), 73-77.
33. J.C. Weikel, A. Wichniak, M. Ising et al., Ghrelin promotes slow-wave sleep in humans, Am J Physiol Endocrinol Metab 284 (2003), E407-E415.
34. B.D. Obay, E. Tasdemir, C. Tümer, H.M. Bilgin and A. Sermet, Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats, Peptides 28 (2007), 1214-1219.
35. H. Yuzuriha, A. Inui, K. Goto, A. Asakawa, M. Fujimiya and M. Kasuga, Intracerebroventricular administration of NPY stimulates resistin gene expression in mice, Int J Mol Med 11 (2003), 675-676.
36. M.J. Vázquez, C.R. González, L. Varela et al., Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion, Endocrinology 149 (2008), 4534-4543.
37. M. Zheng and M. Wang, Study of the relationship between obstructive sleep apnea syndrome and obesity and serum resistin level, Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 22 (2008), 81-83, 94 (in Chinese).
38. K. Piestrzeniewicz, K. Łczak, J. Komorowski, M. Maciejewski, J. Jankiewicz Wika and J.H. Goch, Resistin increases with obesity and atherosclerotic risk factors in patients with myocardial infarction, Metabolism 57 (2008), 488-493.
39. D.A. Rubin, R.G. McMurray, J.S. Harrell, A.C. Hackney, D.E. Thorpe and A.M. Haqq, The association between insulin resistance and cytokines in adolescents: The role of weight status and exercise, Metabolism 57 (2008), 683-690.
40. M.B. Zimmermann and I. Aeberli, Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: A review, Int J Obes (Lond) 32(Suppl 6) (2008), S11-S18.
41. S. Domínguez Coello, A. Cabrera de León, D. Almeida González et al., Inverse association between serum resistin and insulin resistance in humans, Diabetes Res Clin Pract 82 (2008), 256-261.
42. M. Antal, A. Regöly-Mérei, K. Nagy et al., Is there a unique measuring method to assess obesity? Orv Hetil 149 (2008), 1943-1948, (in Hungarian).
43. T. Guran, S. Turan, A. Bereket et al., The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children, Eur J Pediatr (2008), (in press).