Regulation of ghrelin in physiologic and pathophysiologic states

Journal of Nutrition

Volumn 135, Issue 5, 2005, Pages 1320-1325

  Williams, Diana L ^a   Cummings, David E ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Food intake; Ghrelin; Obesity

Indexed keywords

APPETITE STIMULANT; GHRELIN; GROWTH HORMONE RECEPTOR;

APPETITE; BODY MASS; BODY WEIGHT; CONFERENCE PAPER; DIET; FEEDING; FOOD INTAKE; GASTROINTESTINAL TRACT; HUMAN; MEAL; NONHUMAN; NUTRIENT UPTAKE; OBESITY; VAGOTOMY; WEIGHT REDUCTION;

ANIMALIA;

EID: 18344388862     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.5.1320     Document Type: Conference Paper

References (61)

1. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H. & Kangawa, K. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
2. Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M. S., Suganuma, T., Matsukura, S., Kangawa, K. & Nakazato, M. (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255-4261.
3. Dornonville de la Cour, C., Bjorkqvist, M., Sandvik, A. K., Bakke, I., Zhao, C. M., Chen, D. & Hakanson, R. (2001) A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul. Pept. 99: 141-150.
4. Tschop, M., Smiley, D. L. & Heiman, M. L. (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
5. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M. A. & Kasuga, M. (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337-345.
6. Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K. & Matsukura, S. (2001) A role for ghrelin in the central regulation of feeding. Nature 409: 194-198.
7. Hayashida, T., Murakami, K., Mogi, K., Nishihara, M., Nakazato, M., Mondal, M. S., Horii, Y., Kojima, M., Kangawa, K. & Murakami, N. (2001) Ghrelin in domestic animals: Distribution in stomach and its possible role. Domest. Anim. Endocrinol. 21: 17-24.
8. Galas, L., Chartrel, N., Kojima, M., Kangawa, K. & Vaudry, H. (2002) Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta. J. Comp. Neurol. 450: 34-44.
9. Sugino, T., Hasegawa, Y., Kurose, Y., Kojima, M., Kangawa, K. & Terashima, Y. (2004) Effects of ghrelin on food intake and neuroendocrine function in sheep. Anim. Reprod. Sci. 82-83: 183-194.
10. Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A. & Bloom, S. R. (2001) Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86: 5992.
11. Faulconbridge, L. F., Cummings, D. E., Kaplan, J. M. & Grill, H. J. (2003) Hyperphagic effects of brainstem ghrelin administration. Diabetes 52: 2260-2265.
12. Cowley, M. A. (2003) Hypothalamic melanocortin neurons integrate signals of energy state. Eur. J. Pharmacol. 480: 3-11.
13. Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., Kangawa, K. & Nakazato, M. (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123: 1120-1128.
14. Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E. & Weigle, D. S. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719.
15. Sugino, T., Hasegawa, Y., Kikkawa, Y., Yamaura, J., Yamagishi, M., Kurose, Y., Kojima, M., Kangawa, K. & Terashima, Y. (2002) A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep. Biochem. Biophys. Res. Commun. 295: 255-260.
16. Tschop, M., Wawarta, R., Riepl, R. L., Friedrich, S., Bidlingmaier, M., Landgraf, R. & Folwaczny, C. (2001) Post-prandial decrease of circulating human ghrelin levels. J. Endocrinol. Invest. 24: RC19-RC21.
17. Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M. S., Tanaka, M., Nozoe, S., Hosoda, H., Kangawa, K. & Matsukura, S. (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J. Clin. Endocrinol. Metab. 87: 240-244.
18. Tschop, M., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, E. & Heiman, M. L. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707-709.
19. Shimizu, Y., Nagaya, N., Isobe, T., Imazu, M., Okumura, H., Hosoda, H., Kojima, M., Kangawa, K. & Kohno, N. (2003) Increased plasma ghrelin level in lung cancer cachexia. Clin. Cancer Res. 9: 774-778.
20. Nagaya, N., Uematsu, M., Kojima, M., Date, Y., Nakazato, M., Okumura, H., Hosoda, H., Shimizu, W., Yamagishi, M., Oya, H., Koh, H., Yutani, C. & Kangawa, K. (2001) Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation 104: 2034-2038.
21. Murakami, N., Hayashida, T., Kuroiwa, T., Nakahara, K., Ida, T., Mondal, M. S., Nakazato, M., Kojima, M. & Kangawa, K. (2002) Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J. Endocrinol. 174: 283-288.
22. Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E. P. & Purnell, J. Q. (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N. Engl. J. Med. 346: 1623-1630.
23. Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R. & Chapelot, D. (2004) Plasma ghrelin levels and hunger scores among humans initiating meals voluntarily in the absence of time- and food-related cues. Am. J. Physiol. Endocrinol. Metab. 287: E297-E304.
24. Moran, T. H. & Kinzig, K. P. (2004) Gastrointestinal satiety signals II. Cholecystokinin. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G183-G188.
25. Callahan, H. S., Cummings, D. E., Pepe, M. S., Breen, P. A., Matthys, C. C. & Weigle, D. S. (2004) Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J. Clin. Endocrinol. Metab. 89: 1319-1324.
26. Liddle, R. A. (2000) Regulation of cholecystokinin secretion in humans. J. Gastroenterol. 35: 181-187.
27. Overduin, J. S., Frayo, R. S., Grill, H. J., Kaplan, J. M. & Cummings, D. E. (2005) Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology 146: 845-850.
28. Foster-Schubert, K. E., Weigle, D. S., Frayo, R. S., Callahan, H. S. & Cummings, D. E. (2004) Lipids suppress human plasma ghrelin levels less effectively than do carbohydrates or proteins. Endocrine Society, New Orleans, LA.
29. Gomez, G., Englander, E. W. & Greeley, G. H., Jr. (2004) Nutrient inhibition of ghrelin secretion in the fasted rat. Regul. Pept. 117: 33-36.
30. Greenman, Y., Golani, N., Gilad, S., Yaron, M., Limor, R. & Stern, N. (2004) Ghrelin secretion is modulated in a nutrient- and gender-specific manner. Clin. Endocrinol. (Oxf.) 60: 382-388.
31. Stanley, S., Wynne, K. & Bloom, S. (2004) Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G693-G697.
32. Anderwald, C., Brabant, G., Bernroider, E., Horn, R., Brehm, A., Waldhausl, W. & Roden, M. (2003) Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes 52: 1792-1798.
33. Flanagan, D. E., Evans, M. L., Monsod, T. P., Rife, F., Heptulla, R. A., Tamborlane, W. V. & Sherwin, R. S. (2003) The influence of insulin on circulating ghrelin. Am J. Physiol. Endocrinol. Metab. 284: E313-E316.
34. McCowen, K. C., Maykel, J. A., Bistrian, B. R. & Ling, P. R. (2002) Circulating ghrelin concentrations are lowered by intravenous glucose or hyper-insulinemic euglycemic conditions in rodents. J. Endocrinol. 175: R7-R11.
35. Mohlig, M., Spranger, J., Otto, B., Ristow, M., Tschop, M. & Pfeiffer, A. F. (2002) Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J. Endocrinol. Invest. 25: RC36-RC38.
36. Saad, M. F., Bernaba, B., Hwu, C. M., Jinagouda, S., Fahmi, S., Kogosov, E. & Boyadjian, R. (2002) Insulin regulates plasma ghrelin concentration. J. Clin. Endocrinol. Metab. 87: 3997-4000.
37. Murdolo, G., Lucidi, P., Di Loreto, C., Parlanti, N., De Cicco, A., Fatone, C., Fanelli, C. G., Bolli, G. B., Santeusanio, F. & De Feo, P. (2003) Insulin is required for prandial ghrelin suppression in humans. Diabetes 52: 2923-2927.
38. Gelling, R. W., Overduin, J., Morrison, C. D., Morton, G. J., Scott Frayo, R., Cummings, D. E. & Schwartz, M. W. (2004) Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding. Endocrinology 145: 4572-4582.
39. Williams, D. L., Cummings, D. E., Grill, H. J. & Kaplan, J. M. (2003) Meal-related ghrelin suppression requires postgastric feedback. Endocrinology 144: 2765-2767.
40. Wisse, B. E., Frayo, R. S., Schwartz, M. W. & Cummings, D. E. (2001) Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142: 3292-3301.
41. Tacke, F., Brabant, G., Kruck, E., Horn, R., Schoffski, P., Hecker, H., Manns, M. P. & Trautwein, C. (2003) Ghrelin in chronic liver disease. J. Hepatol. 38: 447-454.
42. Leidy, H. J., Gardner, J. K., Frye, B. R., Snook, M. L., Schuchert, M. K., Richard, E. L. & Williams, N. I. (2004) Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J. Clin. Endocrinol. Metab. 89: 2659-2664.
43. Foster-Schubert, K. E., McTiernan, A., Frayo, R. S., Schwartz, R. S., Rojan, K. B., Yasui, Y., Tworoger, S. S. & Cummings, D. E. (2005) Human plasma ghrelin levels increase during a one year exercise program. J. Clin. Endo. Metab. 90: 820-825.
44. Ravussin, E., Tschop, M., Morales, S., Bouchard, C. & Heiman, M. L (2001) Plasma ghrelin concentration and energy balance: Overfeeding and negative energy balance studies in twins. J. Clin. Endocrinol. Metab. 86: 4547-4551.
45. Moesgaard, S. G., Ahren, B., Carr, R. D., Gram, D. X., Brand, C. L. & Sundler, F. (2004) Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach. Regul. Pept. 120: 261-267.
46. Robertson, M. D., Henderson, R. A., Vist, G. E. & Rumsey, R. D. (2004) Plasma ghrelin response following a period of acute overfeeding in normal weight men. Int. J. Obes. Relat. Metab. Disord. 28: 727-733.
47. McLaughlin, T., Abbasi, F., Lamendola, C., Frayo, R. S. & Cummings, D. E. (2004) Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls. J. Clin. Endocrinol. Metab. 89: 1630-1635.
48. Mun, E. C., Blackburn, G. L. & Matthews, J. B. (2001) Current status of medical and surgical therapy for obesity. Gastroenterology 120: 669-681.
49. Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg. 222: 339-350; discussion 350-332.
50. Fruhbeck, G., Diez Caballero, A. & Gil, M. J. (2004) Fundus functionality and ghrelin concentrations after bariatric surgery. N. Engl. J. Med. 350: 308-309.
51. Geloneze, B., Tambascia, M. A., Pilla, V. F., Geloneze, S. R., Repetto, E. M. & Pareja, J. C. (2003) Ghrelin: A gut-brain hormone: Effect of gastric bypass surgery. Obes. Surg. 13: 17-22.
52. Leonetti, F., Silecchia, G., Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Tiberti, C., Iannucci, C. V., Perrotta, N., Bacci, V., Basso, M. S., Basso, N. & Di Mario, U. (2003) Different plasma ghrelin levels after laparoscopic gastric bypass and adjustable gastric banding in morbid obese subjects. J. Clin. Endocrinol. Metab. 88: 4227-4231.
53. Tritos, N. A., Mun, E., Bertkau, A., Grayson, R., Maratos-Flier, E. & Goldfine, A. (2003) Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery. Obes. Res. 11: 919-924.
54. Faraj, M., Havel, P. J., Phelis, S., Blank, D., Sniderman, A. D. & Cianflone, K. (2003) Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J. Clin. Endocrinol. Metab. 88: 1594-1602.
55. Stoeckli, R., Chanda, R., Langer, I. & Keller, U. (2004) Changes of body weight and plasma ghrelin levels after gastric banding and gastric bypass. Obes. Res. 12: 346-350.
56. Holdstock, C., Engstrom, B. E., Ohrvall, M., Lind, L., Sundbom, M. & Karlsson, F. A. (2003) Ghrelin and adipose tissue regulatory peptides: Effect of gastric bypass surgery in obese humans. J. Clin. Endocrinol. Metab. 88: 3177-3183.
57. Hanusch-Enserer, U., Cauza, E., Brabant, G., Dunky, A., Rosen, H., Pacini, G., Tuchler, H., Prager, R. & Roden, M. (2004) Plasma ghrelin in obesity before and after weight loss after laparoscopical adjustable gastric banding. J. Clin. Endocrinol. Metab. 89: 3352-3358.
58. Fruhbeck, G., Diez-Caballero, A., Gil, M. J., Montero, I., Gomez-Ambrosi, J., Salvador, J. & Cienfuegos, J. A. (2004) The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus. Obes. Surg. 14: 606-612.
59. Adami, G. F., Cordera, R., Andraghetti, G., Camerini, G. B., Marinari, G. M. & Scopinaro, N. (2004) Changes in serum ghrelin concentration following biliopancreatic diversion for obesity. Obes. Res. 12: 684-687.
60. Adami, G. F., Cordera, R., Marinari, G., Lamerini, G., Andraghetti, G. & Scopinaro, N. (2003) Plasma ghrelin concentratin in the short-term following biliopancreatic diversion. Obes. Surg. 13: 889-892.
61. Williams, D. L., Grill, H. J., Cummings, D. E. & Kaplan, J. M. (2003) Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144: 5184-5187.