Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4715-4719

  Olimpieri, Francesca ^a   Tambaro, Simone ^b   Fustero, Santos ^c   Lazzari, Paolo ^b   Sanchez Roselló, Maria ^c   Pani, Luca ^b,d   Volonterio, Alessandro ^a,e   Zanda, Matteo ^e,f  

^a Dipartimento di Chimica   (Italy)

^b Neuroscienze PharmaNess Scarl   (Italy)

^c UNIVERSITY OF VALENCIA   (Spain)

^d Sezione di Cagliari   (Italy)

^e CNR   (Italy)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

ACE inhibitors; Fluorine; Michael reaction; NEP inhibitors; Zinc metallopeptidases

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN CONVERTING ENZYME; ENKEPHALINASE INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; TRIFLUOROMETHYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; SOLID PHASE SYNTHESIS;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; FLUORINE; HUMANS; NEPRILYSIN; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PROTEASE INHIBITORS; SULFHYDRYL COMPOUNDS;

EID: 67749118107     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.064     Document Type: Article

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