Dual-isotope single-photon emission computed tomography for dopamine and serotonin transporters in normal and parkinsonian monkey brains

Nuclear Medicine and Biology

Volumn 36, Issue 6, 2009, Pages 605-611

  Li, I Hsun ^a   Huang, Wen Sheng ^b   Yeh, Chin Bin ^b   Liao, Mei Hsiu ^c   Chen, Chia Chieh ^c   Shen, Lie Hang ^c   Liu, Jiang Chuan ^a   Ma, Kuo Hsing ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

Author keywords

123I ADAM; 99mTc TRODAT 1; Dopamine transporter; Dual isotope SPECT; Parkinson's disease; Serotonin transporter

Indexed keywords

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER; IODINE 123; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; IMAGE ANALYSIS; IMAGE QUALITY; INTERMETHOD COMPARISON; MESENCEPHALON; MONKEY; NONHUMAN; PARKINSON DISEASE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

ANIMALS; BRAIN; CINANSERIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEASIBILITY STUDIES; MACACA; ORGANOTECHNETIUM COMPOUNDS; OXIDOPAMINE; PARKINSON DISEASE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 67749103991     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2009.03.003     Document Type: Article

References (44)

1. Gelb D.J., Oliver E., and Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol 56 (1999) 33-39
2. Uhl G.R. Neurotransmitter transporters (plus): a promising new gene family. Trends Neurosci 15 (1992) 265-268
3. 99mTc]TRODAT-1 in hemi-parkinsonism rat brain. Nucl Med Biol 28 (2001) 923-928
4. 123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys. Nucl Med Biol 29 (2002) 561-567
5. Hesse S., Barthel H., Schwarz J., Sabri O., and Muller U. Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders. Neurosci Biobehav Rev 28 (2004) 547-563
6. Owens M.J., and Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 40 (1994) 288-295
7. Kish S.J. Biochemistry of Parkinson's disease: is a brain serotonergic deficiency a characteristic of idiopathic Parkinson's disease?. Adv Neurol 91 (2003) 39-49
8. Paulus W., and Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol 50 (1991) 743-755
9. 123I-beta-CIT SPECT. J Nucl Med 44 (2003) 870-876
10. 123I]beta-CIT SPECT demonstrates decreased brain dopamine and serotonin transporter levels in untreated parkinsonian patients. Mov Disord 16 (2001) 124-130
11. Kerenyi L., Ricaurte G.A., Schretlen D.J., McCann U., Varga J., Mathews W.B., et al. Positron emission tomography of striatal serotonin transporters in Parkinson disease. Arch Neurol 60 (2003) 1223-1229
12. Kugaya A., Seneca N.M., Snyder P.J., Williams S.A., Malison R.T., Baldwin R.M., et al. Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 28 (2003) 413-420
13. Meyer J.H., Wilson A.A., Ginovart N., Goulding V., Hussey D., Hood K., et al. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. Am J Psychiatry 158 (2001) 1843-1849
14. 11C]DASB positron emission tomography study. Am J Psychiatry 161 (2004) 826-835
15. Rickards H. Depression in neurological disorders: Parkinson's disease, multiple sclerosis, and stroke. J Neurol Neurosurg Psychiatry 76 Suppl 1 (2005) i48-i52
16. Carson A.J., Ringbauer B., MacKenzie L., Warlow C., and Sharpe M. Neurological disease, emotional disorder, and disability: they are related: a study of 300 consecutive new referrals to a neurology outpatient department. J Neurol Neurosurg Psychiatry 68 (2000) 202-206
17. Tucker G.J. Neurological disorders and depression. Semin Clin Neuropsychiatry 7 (2002) 213-220
18. Huang W.S., Chiang Y.H., Lin J.C., Chou Y.H., Cheng C.Y., and Liu R.S. Crossover study of (99m)Tc-TRODAT-1 SPECT and (18)F-FDOPA PET in Parkinson's disease patients. J Nucl Med 44 (2003) 999-1005
19. 99mTc]TRODAT-1 in nonhuman primates. Eur J Nucl Med 26 (1999) 342-347
20. 99mTc-TRODAT-1 imaging. J Nucl Med 42 (2001) 1303-1308
21. 18F-FDOPA PET. Nucl Med Commun 24 (2003) 77-83
22. 99mTc-TRODAT-1 SPET for the evaluation of Parkinson's disease. Eur J Nucl Med Mol Imaging 31 (2004) 155-161
23. Oya S., Choi S.R., Hou C., Mu M., Kung M.P., Acton P.D., et al. 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol 27 (2000) 249-254
24. 123I]ADAM SPECT in a parkinsonian primate model. Appl Radiat Isot 66 (2008) 1799-1803
25. 123I-ADAM brain SPECT in healthy non-human primates. Nucl Med Commun 25 (2004) 515-519
26. Scholtissen B., Verhey F.R., Steinbusch H.W., and Leentjens A.F. Serotonergic mechanisms in Parkinson's disease: opposing results from preclinical and clinical data. J Neural Transm 113 (2006) 59-73
27. 99mTc-TRODAT-1 SPECT imaging in differentiating patients with idiopathic Parkinson's disease from healthy subjects. J Nucl Med 45 (2004) 393-401
28. 99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor. Acta Neurol Scand 112 (2005) 380-385
29. 99mTc-TRODAT-1 imaging of multiple system atrophy. J Nucl Med 45 (2004) 49-55
30. Kanyo B., Argyelan M., Dibo G., Szakonyi Z., Vecsei L., Fulop F., et al. Imaging of dopamine transporter with Tc99m-Trodat-SPECT in movement disorders. Ideggyogy Sz 56 (2003) 231-240
31. 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson's disease. J Nucl Med 45 (2004) 207-213
32. 99mTc-TRODAT-1 SPECT imaging in idiopathic Parkinson's disease. J Zhejiang Univ Sci B 6 (2005) 22-27
33. 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med 46 (2005) 973-977
34. 123I]beta-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin 42 (2003) 31-38
35. Carvey P.M., Punati A., and Newman M.B. Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplant 15 (2006) 239-250
36. Schober A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res 318 (2004) 215-224
37. Betarbet R., Sherer T.B., and Greenamyre J.T. Animal models of Parkinson's disease. Bioessays 24 (2002) 308-318
38. Przedborski S., Jackson-Lewis V., Naini A.B., Jakowec M., Petzinger G., Miller R., et al. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem 76 (2001) 1265-1274
39. Ruffy R., and Leonard M. Chemical cardiac sympathetic denervation hampers defibrillation in the dog. J Cardiovasc Electrophysiol 8 (1997) 62-67
40. Bove J., Prou D., Perier C., and Przedborski S. Toxin-induced models of Parkinson's disease. NeuroRx 2 (2005) 484-494
41. Devous Sr. M.D., Payne J.K., and Lowe J.L. Dual-isotope brain SPECT imaging with technetium-99m and iodine-123: clinical validation using xenon-133 SPECT. J Nucl Med 33 (1992) 1919-1924
42. Dresel S.H., Kung M.P., Huang X.F., Plossl K., Hou C., Meegalla S.K., et al. Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. J Nucl Med 40 (1999) 660-666
43. Devous Sr. M.D., Lowe J.L., and Payne J.K. Dual-isotope brain SPECT imaging with technetium-99m and iodine-123: validation by phantom studies. J Nucl Med 33 (1992) 2030-2035
44. 123I radioisotopes: a double-injection technique for peri-ictal functional neuroimaging. J Nucl Med 40 (1999) 677-684